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| 1 | Neuroprotective effects of human bone marrow mesenchymal stem cells against cerebral ischemia are mediated in part by an anti-apoptotic mechanism显示文摘Transplantation of human bone marrow mesenchymal stem cells(hMSCs) stands as a potent stroke therapy, but its exact mechanism remains unknown. This study investigated the anti-apoptotic mechanisms by which hMSCs exert neuroprotective effects on cerebral ischemia. Primary mixed cultures of rat neurons and astrocytes were cultured and exposed to oxygen-glucose deprivation. A two-hour period of 'reperfusion' in standard medium and normoxic conditions was allowed and immediately followed by hMSCs and/or Bcl-2 antibody treatment. Cell viability of primary rat neurons and astrocytes was determined by 3-(4,5-dimethylthianol-2-yl)-2,5 diphenyl tetrazolium bromide and trypan blue exclusion methods. hMSC survival and differentiation were characterized by immunocytochemistry, while the concentration of Bcl-2 in the supernatant was measured by enzyme-linked immunosorbent assay to reveal the secretory anti-apoptotic function of hMSCs. Cultured hMSCs expressed embryonic-like stem cell phenotypic markers CXCR4, Oct4, SSEA4, and Nanog, as well as immature neural phenotypic marker Nestin. Primary rat neurons and astrocytes were protected from oxygen-glucose deprivation by hMSCs, which was antagonized by the Bcl-2 antibody. However, Bcl-2 levels in the supernatants did not differ between hMSCand non-treated cells exposed to oxygen-glucose deprivation. Neuroprotective effects of hMSCs against cerebral ischemia were partially mediated by the anti-apoptotic mechanisms. However, further studies are warranted to fully elucidate this pathway. | Yuyang Zhang Seongjin Yu Julian P.Tuazon Jea-Young Lee Sydney Corey Lauren Kvederis Chase Kingsbury Yuji Kaneko Cesar V.Borlongan | 2019 | Neural Regeneration Research2019，14，4： | 9 |
| 2 | Fast-tracking regenerative medicine for traumatic brain injury显示文摘Traumatic brain injury remains a global health crisis that spans all demographics,yet there exist limited treatment options that may effectively curtail its lingering symptoms.Traumatic brain injury pathology entails a progression from primary injury to inflammation-mediated secondary cell death.Sequestering this inflammation as a means of ameliorating the greater symptomology of traumatic brain injury has emerged as an attractive treatment prospect.In this review,we recapitulate and evaluate the important developments relating to regulating traumatic brain injury-induced neuroinflammation,edema,and blood-brain barrier disintegration through pharmacotherapy and stem cell transplants.Although these studies of stand-alone treatments have yielded some positive results,more therapeutic outcomes have been documented from the promising area of combined drug and stem cell therapy.Harnessing the facilitatory properties of certain pharmaceuticals with the anti-inflammatory and regenerative effects of stem cell transplants creates a synergistic effect greater than the sum of its parts.The burgeoning evidence in favor of combined drug and stem cell therapies warrants more elaborate preclinical studies on this topic in order to pave the way for later clinical trials. | Brooke Bonsack Matt Heyck Chase Kingsbury Blaise Cozene Nadia Sadanandan Jea-Young Lee Cesar V. Borlongan | 2020 | Neural Regeneration Research2020，15，7： | 5 |
| 3 | Complex Wavelets for Shift Invariant Analysis and Filtering of Signals显示文摘 | Nick Kingsbury | 2001 | Applied and Computational Harmonic Analysis2001，，3： | 3 |
| 4 | Synthesis of water-soluble(aminoalkyl) camptothecin analogues: inhibition of topoisomerase I and antitumor activity显示文摘 | Kingsbury WD Boehm JC Jakas DR | 1991 | J Med Chem1991，34，： | 2 |
| 5 | Stroke gets in your eyes: stroke-induced retinal ischemia and the potential of stem cell therapy显示文摘Stroke persists as a global health and economic crisis,yet only two interventions to reduce stroke-induced brain injury exist.In the clinic,many patients who experience an ischemic stroke often further suffer from retinal ischemia,which can inhibit their ability to make a functional recovery and may diminish their overall quality of life.Despite this,no treatments for retinal ischemia have been developed.In both cases,ischemia-induced mitochondrial dysfunction initiates a cell loss cascade and inhibits endogenous brain repair.Stem cells have the ability to transfer healthy and functional mitochondria not only ischemic neurons,but also to similarly endangered retinal cells,replacing their defective mitochondria and thereby reducing cell death.In this review,we encapsulate and assess the relationship between cerebral and retinal ischemia,recent preclinical advancements made using in vitro and in vivo retinal ischemia models,the role of mitochondrial dysfunction in retinal ischemia pathology,and the therapeutic potential of stem cell-mediated mitochondrial transfer.Furthermore,we discuss the pitfalls in classic rodent functional assessments and the potential advantages of laser Doppler as a metric of stroke progression.The studies evaluated in this review highlight stem cell-derived mitochondrial transfer as a novel therapeutic approach to both retinal ischemia and stroke.Furthermore,we posit the immense correlation between cerebral and retinal ischemia as an underserved area of study,warranting exploration with the aim of these treating injuries together. | Chase Kingsbury Matt Heyck Brooke Bonsack Jea-Young Lee Cesar V.Borlongan | 2020 | Neural Regeneration Research2020，15，6： | 2 |
| 6 | The dualt tree complex wavelet transform 显示文摘 | Selesnick I W Baraniuk R G and Kingsbury N G | 2005 | IEEE Signal Processing Magazine2005，22，6： | 1 |
| 7 | The dual-tree complex wavelet transform显示文摘 | SELESNICK I W BARANIUK R G KINGSBURY N G | 2005 | IEEE Signal Processing Magazine2005，14，1： | 1 |
| 8 | The dual-tree complex wavelet transform显示文摘 | SELESNICK I W BARANIUK R G KINGSBURY N G | 2005 | IEEE Signal Processing Magazine2005，22，6： | 1 |
| 9 | The duat-tree complex wavelet transform 显示文摘 | SELESNICK I W BARANIUK R G KINGSBURY N G | 2005 | IEEE Signal Processing Magazine2005，22，6： | 1 |
| 10 | The rCBF response to Diamox in normal subjects and cerebrovascutar disease patients显示文摘 | Sullivan HG Kingsbury IV TB Morgan ME | 1987 | J Neurosurg1987，67，： | 1 |
| 11 | The dual-tree complex wavelet transform显示文摘 | Selesnick L W Baraniuk R G Kingsbury N C | 2005 | IEEE Signal Processing Magazine2005，6，22： | 1 |
| 12 | Physiological responses to salinity in selected lines of wheat显示文摘 | Kingsbury R W Epstein E Peary R W | 1984 | Plant Physiology1984，74，： | 1 |
| 13 | Image Processing with Complex Wavelets 显示文摘 | Kingsbury N | 1999 | Philos Trans Royal Society London A1999，357，9： | 1 |
| 14 | Response of poroelastic layers to moving loads显示文摘 | BURKE M KINGSBURY H B | 1984 | International Journal of Solids and Structures1984，20，： | 1 |
| 15 | The Proposition Bank: An Annotated Corpus of Semantic Roles显示文摘 | M Palmer D Gildea P Kingsbury | 2005 | Computational Linguistics2005，31，1： | 1 |
| 16 | The dual-tree complex wavelet transform显示文摘 | Selesnick I W Baraniuk R G Kingsbury N G | | 0，，06： | 1 |
| 17 | A multifunctional Pd/alumina hollow fibre membrane reactor for propane dehydrogenation显示文摘 | Ejiro Gbenedio Zhentao Wu Irfan Hatim Benjamin F.K. Kingsbury K. Li | 2010 | Catalysis Today2010，，3： | 1 |
| 18 | Image processing with complex wavelets 显示文摘 | Kingsbury N G | 1999 | Philosophical Transactions:Mathematical Physical and Engineering Sciences1999，35，160： | 1 |
| 19 | Complex wavelets for shift invariant analysis and filtering of signal显示文摘 | KINGSBURY N G | 2001 | Applied Computer Harmon Anal2001，，3： | 1 |
| 20 | Complex wavelet for shift invariant analysis and filtering of signals 显示文摘 | KINGSBURY N G | 2001 | Applied and Computational Harmonic A- nalysis2001，10，3： | 1 |
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