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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Bronchopulmonary dysplasia 显示文摘 | Kinsella JP Greenough A Abman SH | 2006 | Lancet2006，367，9520： | 1 |
| 3 | Inhibition of human LDL oxidation by resveratml显示文摘 | FRANKEL E N WATERHOUSE A L KINSELLA J E | 1993 | Lancet1993，341，8852： | 1 |
| 4 | Determination of anthelmintic drug residues in milk using ultra high performance liquid chromatography-tandem mass spectrometry with rapid polarity switching显示文摘 | WHELAN M KINSELLA B FUREY A | 2010 | Journal of Chromatography A2010，1217，27： | 1 |
| 5 | Dietary n-3 polyunsaturated fatty acids and amelioration of cardiovascular disease:possible mechanisms显示文摘 | Kinsella J E Lokesh B Stone R A | 1990 | The American journal of clinical nutrition1990，52，1： | 1 |
| 6 | Estrogen receptor(ER),progesterone receptor(PR),and HER2 expression pre-and post-neoadjuvant chemotherapy in primary breast carcinoma:a single institutional experience显示文摘 | Kinsella MD Nassar A Siddiqui MT | 2012 | Int J Clin Exp Pathol2012，5，6： | 1 |
| 7 | Bronchopulmonary dysplesia显示文摘 | Kinsella JP Greenough A Abman SH | 2006 | Lancet2006，367，9520： | 1 |
| 8 | Formate protects stationaryphase Escherichia coil and Salmonella ceils from killing by a cationic antimicrobial peptide显示文摘 | Barker HC Kinsella N Jaspe A | 2000 | Mol Microbiol2000，35，6： | 1 |
| 9 | Distal symmetric polyneuropathy: A definition for clinical research: Report of the American Academy of Neurology, the American Association of Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation显示文摘 | J D. England G S. Gronseth G Franklin R G. Miller A K. Asbury G T. Carter J A. Cohen M A. Fisher J F. Howard L J. Kinsella N Latov R A. Lewis P A. Low A J. Sumner | 2005 | Neurology2005，，2： | 1 |
| 10 | Bronchopulmonary displasia 显示文摘 | Kinsella JP Greenough A Abman SH | 2006 | Lancet2006，367，9520： | 1 |
| 11 | Interactions of putative heparin-binding domains of basic fibroblast growth facior and its receptor, FGFR- 1, with heparin using synthetic peptides 显示文摘 | Kinsella L Chen H L Smith J A | 1998 | Glycoconj J1998，15，： | 1 |
| 12 | Sequence determination of the Crimean Congo hemorrhagic fever virus L segment显示文摘 | Kinsella E Sandra GM Grolla A | 2004 | Virology2004，321，： | 1 |
| 13 | Bronchopulmonary dysplasia显示文摘 | Kinsella JP Greenough A Abman SH | 2006 | Lancet2006，367，9520： | 1 |
| 14 | Cadmium uptake and toxicity via voltage-sensitive calcium channels显示文摘 | Hinkle P M Kinsella P A Osterhoudt K C | 1987 | Journal Biology Chemistry1987，262，16： | 1 |
| 15 | Cadmiumuptake and toxicity via voltage-sensitive calciumchannels 显示文摘 | Hinkle P M Kinsella P A Osterhoudt K C | 1987 | J Biol Chem1987，262，16： | 1 |
| 16 | Bronchopulmonary dysplasia显示文摘 | Kinsella JP Greenough A Abman S H | 2006 | Lancet2006，367，9520： | 1 |
| 17 | The psychological burden of idiopathic adolescent gynecomastia显示文摘 | Kinsella C J Landfair A Ptottgers SA | 2012 | Plast Reconstr Surg2012，129，1： | 1 |
| 18 | Formate protects stationary-phase Escherichia coli and Salmonella cells from killing by a cationic antimicrobial peptide 显示文摘 | BARKER H C KINSELLA N JASPE A | 2000 | Mol Microbiol2000，35，： | 1 |
| 19 | Inhibition of human LDL oxidation by resveratrol 显示文摘 | Frankel E N Waterhouse A L Kinsella J E | 1993 | Lancet1993，341，2： | 1 |
| 20 | The demographics of aging:Aging Clin显示文摘 | Kinsella K Velkoff V A | 2002 | Exp Res2002，14，： | 1 |
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