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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Inhibition of human LDL oxidation by resveratml显示文摘 | FRANKEL E N WATERHOUSE A L KINSELLA J E | 1993 | Lancet1993，341，8852： | 1 |
| 3 | Functional properties of acetylated and succinylated soy protein显示文摘 | Franzen K L Kinsella J E | 1976 | Journal of Agricultural and Food Chemistry1976，24，： | 1 |
| 4 | Indications,results and safetyprofile of transperineal sector biopsies (TPSB) of the prostate:asingle centre experience of 634 cases显示文摘 | Vyas L Acher P Kinsella J | 2014 | BJU Int2014，114，1： | 1 |
| 5 | Distal symmetric polyneuropathy: A definition for clinical research: Report of the American Academy of Neurology, the American Association of Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation显示文摘 | J D. England G S. Gronseth G Franklin R G. Miller A K. Asbury G T. Carter J A. Cohen M A. Fisher J F. Howard L J. Kinsella N Latov R A. Lewis P A. Low A J. Sumner | 2005 | Neurology2005，，2： | 1 |
| 6 | Interactions of putative heparin-binding domains of basic fibroblast growth facior and its receptor, FGFR- 1, with heparin using synthetic peptides 显示文摘 | Kinsella L Chen H L Smith J A | 1998 | Glycoconj J1998，15，： | 1 |
| 7 | Interactions of putative heparinbinding domains of basic fibroblast growth factor and its receptor,FGFR-1 ,with heparin using synthetic peptides 显示文摘 | Kinsella L Chen HL Smith JA | 1998 | Glycoconj J1998，15，： | 1 |
| 8 | Functional properties of succinylated and acetylated soy protein显示文摘 | FRANZEN K L KINSELLA J E | 1976 | Journal of Agriculture and Food Chemistry1976，24，4： | 1 |
| 9 | Neutral Salt Effects on Stability of Whey Protein Isolate Foams 显示文摘 | Phillips L G Yang S T Kinsella J E | 1991 | Journal of Food Science1991，56，： | 1 |
| 10 | Inhibition of human LDL oxidation by resveratrol 显示文摘 | Frankel E N Waterhouse A L Kinsella J E | 1993 | Lancet1993，341，2： | 1 |
| 11 | Functional proprties of succinylated and cetylate soy protein显示文摘 | Franzen K L Kinsella J E | 1976 | Agric Food Chem1976，24，4： | 1 |
| 12 | Interactions of putative heparin-binding domains of basic fibroblast growth factor and itsrecep tor,FGFR-1,with heparin using synthetic pep tides显示文摘 | Kinsella L Chen HL Smith JA | 1998 | Glycoconj J1998，15，： | 1 |
| 13 | Functional properties of acetylatedand succinylated soy protein 显示文摘 | Franzen K L Kinsella J E | 1976 | Journal of Agricultural andFoodChemistiy1976，24，： | 1 |
| 14 | Functional properties of succinylated and acetylated soy protein显示文摘 | Franzen Kay L kinsella John E | 1976 | J Agric Food Chem1976，24，4： | 1 |
| 15 | Use of dietary yeast Sac- charomyces cerevisiae nitrogen by lake trout 显示文摘 | Rumsey G L Hughes S G Kinsella L | 1990 | J World Aquacul- ture Society1990，21，： | 1 |
| 16 | Functional properties ofsuccinylated protein显示文摘 | Franzen kay L Kinsella John E | 1976 | Agric Food Chem1976，24，4： | 1 |
| 17 | Functional properties of suc- cinylated and acetylated soy protein显示文摘 | FRANZEN K L KINSELLA J E | 1976 | Journal of Agricultural Food and Chemistry1976，24，4： | 1 |
| 18 | Corrosion inhibition by self-assembled monolayers for enhanced wire bonding on Cu surfaces显示文摘 | WHELAN C M KINSELLA M CARBONELL L | 2003 | Microelectronic Engineering2003，70，24： | 1 |
| 19 | The role of basement membrane in angiogenesis and tumor growth 显示文摘 | GRANT D S KIBBEY M C KINSELLA J L | 1994 | PatholRes Pract1994，190，910： | 1 |
| 20 | Scatter factor induces blood vessel formation in vivo 显示文摘 | Grant D S Kleinman H K Goldberg I D Bhargava M M Nickoloff B J Kinsella J L | 1993 | Proc Natl Acad Sci USA1993，90，： | 1 |
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