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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Extensive cervical lymphadenitis due to Mycobacterium avium-intracellulare显示文摘 | Kinsella J P Culver K Jeffrey R B | 1987 | Pediatr Infect Dis J1987，6，： | 1 |
| 3 | Dietary n-3 polyunsaturated fatty acids and amelioration of cardiovascular disease:possible mechanisms显示文摘 | Kinsella J E Lokesh B Stone R A | 1990 | The American journal of clinical nutrition1990，52，1： | 1 |
| 4 | Comparison of methods for separating oligosaccharides: ultrafiltration, gel permeation and adsorption chromatography显示文摘 | Waniska R D Kinsella J E | 1980 | J Food Sci1980，45，5： | 1 |
| 5 | Distal symmetric polyneuropathy: A definition for clinical research: Report of the American Academy of Neurology, the American Association of Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation显示文摘 | J D. England G S. Gronseth G Franklin R G. Miller A K. Asbury G T. Carter J A. Cohen M A. Fisher J F. Howard L J. Kinsella N Latov R A. Lewis P A. Low A J. Sumner | 2005 | Neurology2005，，2： | 1 |
| 6 | X-Ray computed tomography imaging of breast cancer by using targeted peptide-labeledbismuth sulfide nanoparticles显示文摘 | KINSELLA J M JIMENEZ R E KARMALI P P | 2011 | Angew Chem Int Ed2011，50，12： | 1 |
| 7 | Foaming properties of proteins: evaluation of a column aeration apparatus using albumin显示文摘 | Waniska R D Kinsella J E | 1979 | Journal of Food Science1979，44，： | 1 |
| 8 | Lipoxygenase generation of specific flavor carbonyl compounds in fish tissues 显示文摘 | Hsieh R J Kinsella J E | 1989 | J Agric Food Chem1989，37，： | 1 |
| 9 | Pharyngo-laryngo-oesophagectomy and gastric pull-up for post-cricoid and cervical oesophageal squamous cell carcinoma显示文摘 | Ullah R Bailie N Kinsella J | 2002 | J Laryngol Otol2002，116，10： | 1 |
| 10 | Foaming properties of proteins : evaluation of a column aeration apparatus using al- bumin 显示文摘 | Waniska R D Kinsella J E | 1979 | Journal of Food Science1979，44，： | 1 |
| 11 | Liploxygenase in fish tissue:some properties of 12-lipoxygenase from trout gill 显示文摘 | Hsieh R J German J B Kinsella J E | 1988 | Journal of Agricultural and Food Chemistry1988，36，： | 1 |
| 12 | A Study of the Adsorption Properties of Commercial Carbon Dioxide Corrosion Inhibitor Formulations显示文摘 | DURNIE W H KINSELLA B J MARCO R D et aI | 2001 | Journal of Applied Electrochemistry2001，31，11： | 1 |
| 13 | Ther- mal decomposition products of fiberglass composites, A fou- rier transform infrared analysis显示文摘 | KINSELLA K MARKHAM J R NELSON C M | 1997 | Journal of Fire Science1997，15，2： | 1 |
| 14 | Acellular dermal matrix in the treatment and prevention of exposed vertical expandable pros- thetic titanium ribs 显示文摘 | Gill R Kinsella CR Jr Lin AY | 2011 | Spine ( Phila Pa 1976 )2011，36，8： | 1 |
| 15 | Combined suicide and granulocyte macrophage colony stimulating factor gene therapy induces complete tumor regression and generates antitumor immunity显示文摘 | Jones P K Pppel M Kinsella A R | 2000 | Cancer Gene Therapy2000，7，： | 1 |
| 16 | Low-dose inhaled nitric oxide in persistent pulmonary hypertension of the newborn 显示文摘 | Kinsella J P Neish S R Sbaffer E | 1992 | Lancet1992，340，8823： | 1 |
| 17 | Customer defection: a study of the student market in Ireland 显示文摘 | Colgate M Stewart K Kinsella R | 1996 | International Journal of Bank Marketing1996，14，3： | 1 |
| 18 | Dual origin of the left vertebral artery: extracranial MRA and CTA findings显示文摘 | Tobin W O Killeen R Kinsella J A | 2010 | J Neu- rol Sci2010，298，12： | 1 |
| 19 | Antioxidant: Flavonoids in Adv 显示文摘 | Hsieh R J G Kinsella | 1989 | Food Nutr Res1989，，33： | 1 |
| 20 | Multiple sclerosis prevalence in Ireland:relationship to vitamin D status and HLA genotype显示文摘 | Lonergan R Kinsella K Fitzpatrick P | 2011 | Neurol Neurosurg Psychiatry2011，82，3： | 1 |
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