|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Casein kinase 2 regulates both apop- tosis and the cell cycle following DNA damage induced by 6 - thio- guanine显示文摘 | YAMANE K KINSELLA T J | 2005 | Clin Cancer Res2005，11，6： | 1 |
| 3 | Methyl ketone formation during germination of Penicillium roqueforti显示文摘 | FAN T HWANG D KINSELLA J | 1976 | J Agric Food Chem1976，，24： | 1 |
| 4 | Negative fluid balance as predictor of mortality显示文摘 | Quasim T Mcmillan DC Kinsella J | 2001 | Chest2001，120，4： | 1 |
| 5 | Binding of alkanone flavors to beta-lactoglobulin: effects of conformational and chemical modification 显示文摘 | O’Neill T E Kinsella J E | 1987 | Journal of Agricultural and Food Chemistry1987，35，5： | 1 |
| 6 | Neutral Salt Effects on Stability of Whey Protein Isolate Foams 显示文摘 | Phillips L G Yang S T Kinsella J E | 1991 | Journal of Food Science1991，56，： | 1 |
| 7 | 5-iodo-2-pyri-midinone-2'-deoxyribose-mediated cytotoxicity and radiosensitization in U87 human glioblastoma xenografts显示文摘 | KINSELLA T J KINSELLA M T SEO Y | 2007 | Int J Radiat Oncol Biol Phys2007，69，4： | 1 |
| 8 | Toxicology and pharmacokinetic study of orally administered 5-iodo-2-pyrimidinone-2'deoxyribose (IPdR) x 28 days in Fischer-344 rats:impact on the initial clinical phase I trial design of IPdR-mediated radiosensitization显示文摘 | KINSELLA T J KINSELLA M T HONG S | 2008 | Cancer Chemother Pharmacol2008，61，2： | 1 |
| 9 | Effect of heat treatment and modification on conformation and flavor binding by β-lactoglobulin显示文摘 | Neill T E Kinsella J E | 1988 | J Food Sci1988，53，： | 1 |
| 10 | Prediction of gait velocity in ambulatory stroke patients during rehabilitation 显示文摘 | Matyas T Kinsella GJ | 1999 | Arch Phys Med Rehabil1999，80，： | 1 |
| 11 | Sensitization i- dentification of stainless steel to intergranular stress corrosion cracking by atomic force microscopy显示文摘 | YANLIANG H KINSELLA B BECKER T | 2007 | Mater Lett2007，12，13： | 1 |
| 12 | Impact of a novel spray-chilling system on surface microflora,water activity and weight loss during beef carcass chilling显示文摘 | Kinsella K J Sheridan J J Rowe T A | 2006 | Food Microbiology2006，23，： | 1 |
| 13 | Casein kinase 2 regulates both apoptosis and the cell cycle following DNA damage induced by 6-thioguanine显示文摘 | Yamane K I Kinsella T J | 2005 | Clin Cancer Res2005，11，6： | 1 |
| 14 | Effect of disulfide bond cleavage on structural and interfacial properties of whey proteins显示文摘 | Kella N K D Yang S T Kinsella J E | 1989 | Food Chem1989，37，5： | 1 |
| 15 | Increased thymidylate synthase protein levels are principally associated with proliferation but not cell cycle phase in asynchronous human cancercells显示文摘 | Pestalozzi B C McGinn C J Kinsella T J | 1995 | BrJ Cancer1995，71，6： | 1 |
| 16 | Rapid quantification of Bacillus subtilis antibiotics in the rhizosphere显示文摘 | Kinsella K Schulthess C P Morris T F | 2009 | Soil Biology and Biochemistry2009，41，2： | 1 |
| 17 | Mammalian target of rapamycinand S6 kinase 1 positively regulate 6-thioguanine-in-duced autophagy显示文摘 | Zeng X’Kinsella T J | 2008 | Cancer Res2008，68，6： | 1 |
| 18 | Rapid quantification of Bacillus subtilis antibiotics in the rhizosphere显示文摘 | Kinsella K Schulthess C P Morris T F | 2009 | Soil Biology and Biochemistry2009，41，2： | 1 |
| 19 | Casein kinase 2 regulates both apopto- sis and the cell cycle following DNA damage induced by 6-thio- guanine显示文摘 | Yamane K Kinsella T J | 2005 | Clin Cancer Res2005，11，6： | 1 |
| 20 | High eficiency gene transfer and selection of human hematope ietic progenitor cells with a hybrid EBV/ retroviral vector expressing the green fluorescence protein 显示文摘 | Grilgnani F Kinsella T Mencarelli A | 1998 | Cancer Res1998，58，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员