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| 1 | Role of gut microbiota in cardiovascular diseases显示文摘The human gut is colonized by a community of microbiota,primarily bacteria,that exist in a symbiotic relationship with the host.Intestinal microbiota-host interactions play a critical role in the regulation of human physiology.Deleterious changes to the composition of gut microbiota,referred to as gut dysbiosis,has been linked to the development and progression of numerous diseases,including cardiovascular disease(CVD).Imbalances in host-microbial interaction impair homeostatic mechanisms that regulate health and can activate multiple pathways leading to CVD risk factor progression.Most CVD risk factors,including aging,obesity,dietary patterns,and a sedentary lifestyle,have been shown to induce gut dysbiosis.Dysbiosis is associated with intestinal inflammation and reduced integrity of the gut barrier,which in turn increases circulating levels of bacterial structural components and microbial metabolites,including trimethylamine-N-oxide and short-chain fatty acids,that may facilitate the development of CVD.This article reviews the normal function and composition of the gut microbiome,mechanisms leading to the leaky gut syndrome,its mechanistic link to CVD and potential novel therapeutic approaches aimed towards restoring gut microbiome and CVD prevention.As CVD is the leading cause of deaths globally,investigating the gut microbiota as a locus of intervention presents a novel and clinically relevant avenue for future research. | Marko Novakovic Amit Rout Thomas Kingsley Robert Kirchoff Amteshwar Singh Vipin Verma Ravi Kant Rahul Chaudhary | 2020 | World Journal of Cardiology2020，12，4： | 6 |
| 2 | A supercritical clean machine 显示文摘 | | 2000 | ChemMatters2000，，4： | 1 |
| 3 | Comparative genomic hybridization reveals non-random chromosomal aberrations in early preinvasive cervical lesions显示文摘 | Kirchoff M Rose H Petersen BL | 2001 | Cancer Genet Cytogenet2001，109，1： | 1 |
| 4 | Oncologic Colorectal Resection, Not Advanced Endoscopic Polypectomy, Is the Best Treatment for Large Dysplastic Adenomas显示文摘 | Joon Ho Jang Emre Balik Daniel Kirchoff Wouter Tromp Anjali Kumar Michael Grieco Daniel L. Feingold Vesna Cekic Linda Njoh Richard L. Whelan | 2012 | Journal of Gastrointestinal Surgery2012，，1： | 1 |
| 5 | Homeosis in the flowers of the Zingiberales显示文摘 | Kirchoff B K | 1991 | American Journal of Botany1991，78，： | 1 |
| 6 | Identification and characterization of nine polymorphic microsatellite loci in the North American pika,Ochotona princes显示文摘 | Veronica S Kirchoff and Susan J Merideth | 2002 | Molecukar Ecology Notes2002，11，2： | 1 |
| 7 | Laparoscopic- facilitated endoscopic submucosal dissection, mucosal resection, and partial circumferential ('wedge') colon wall resection for benign colorectal neoplasms that come to surgery 显示文摘 | Jang JH Kirchoff D Holzman K | 2013 | Surg Innov2013，20，： | 1 |
| 8 | Microglia: new roles for the synaptic stripper显示文摘 | KE13'ENMAN N H KIRCHOFF F VERHRATSKY A | 2013 | Neuron2013，77，1： | 1 |
| 9 | Plasma from the second and third weeks after open colorectal resection for cancer stimulates in vitro endothelial cell growth, migration, and invasion显示文摘 | H. M. C. Shantha Kumara Daniel Kirchoff Samer Naffouje Michael Grieco Sonali A. C. Herath Nadav Dujovny Matthew F. Kalady Neil Hyman Linda Njoh Richard L. Whelan | 2012 | Surgical Endoscopy2012，，3： | 1 |
| 10 | Plasma monocyte chemotactic protein-1 remains elevated after minimally invasive colorectal cancer resection显示文摘AIM: To investigate plasma Monocyte Chemotactic Protein-1 levels preoperatively in colorectal cancer(CRC) and benign patients and postoperatively after CRC resection.METHODS: A plasma bank was screened for minimally invasive colorectal cancer resection(MICR) for CRC and benign disease(BEN) patients for whom preoperative, early postoperative, and 1 or more late postoperative samples(postoperative day 7-27) were available. Monocyte chemotactic protein-1(MCP-1) levels(pg/mL) were determined via enzyme linked immuno-absorbent assay. RESULTS: One hundred and two CRC and 86 BEN patients were studied. The CRC patient's median preoperative MCP-1 level(283.1, CI: 256.0, 294.3) was higher than the BEN group level(227.5, CI: 200.2, 245.2; P = 0.0004). Vs CRC preoperative levels, elevated MCP-1 plasma levels were found on postoperative day 1(446.3, CI: 418.0, 520.1), postoperative day 3(342.7, CI: 320.4, 377.4), postoperative day 7-13(326.5, CI: 299.4, 354.1), postoperative day 14-20(361.6, CI: 287.8, 407.9), and postoperative day 21-27(318.1, CI: 287.2, 371.6; P < 0.001 for all). CONCLUSION: Preoperative MCP-1 levels were higher in CRC patients(vs BEN). After MICR for CRC, MCP-1 levels were elevated for 1 mo and may promote angiogenesis, cancer recurrence and metastasis. | HMC Shantha Kumara Elizabeth A Myers Sonali AC Herath Joon Ho Jang Linda Njoh Xiaohong Yan Daniel Kirchoff Vesna Cekic Martin Luchtefeld Richard L Whelan | 2014 | World Journal of Gastrointestinal Oncology2014，6，10： | 1 |
| 11 | Laparoscopic- facilitated endoscopic submucosal dissection, mucosal resection, and partial circumferential ('wedge') colon wall resection for benign colorectal neoplasms that come to surgery 显示文摘 | Jang JH Kirchoff D Holzman K | 2013 | Surg Innov2013，20，： | 1 |
| 12 | A major human epididym is-specific cDNA encodes a prote in with sequence homology to extracellular prote in as einhibitors显示文摘 | Kirchoff C Habben I Ivell R | 1991 | Biol Rep Rod1991，45，2： | 1 |
| 13 | Plasma from the second and third weeks after open colorectal resection for cancer stimulates in vitro endothelial cell growth, migration, and invasion显示文摘 | H. M. C. Shantha Kumara Daniel Kirchoff Samer Naffouje Michael Grieco Sonali A. C. Herath Nadav Dujovny Matthew F. Kalady Neil Hyman Linda Njoh Richard L. Whelan | 2012 | Surgical Endoscopy2012，，： | 1 |
| 14 | Plasma fromthe second and third weeks after open colorectal resection forcancer stimulates in vitro endothelial cell growth, migration, andinvasion显示文摘 | Shantha Kumara HM Kirchoff D Naffouje | 2012 | Surg Endosc2012，26，3： | 1 |
| 15 | Inflorescence and floral development in Orchidantha muxiillarioides (LLowiaceae) 显示文摘 | Kirchoff B K Kunze H | 1995 | Inter J Plant Sci1995，156，： | 1 |
| 16 | Assessment of a novel screening score for nutrition risk in predicting complications in gastrointestinal surgery 显示文摘 | Scheisscr M MUller S Kirchoff P | 2008 | Clin Nutr2008，27，4： | 1 |
| 17 | Reduced cardiac conduction velocity and predisposition to arrhythmias in connexin40-deficient mice显示文摘 | Kirchoff S Nelles E Hagendorff A | 1998 | Curr Biol1998，8，5： | 1 |
| 18 | Transaterial chemoembolization and percutaneous ethanol injection therapy in patients with hepatocellular carcinoma显示文摘 | Kirchoff T Chavan A GalanskiM | 1998 | EurJ Gastroenterol Hepatol1998，10，： | 1 |
| 19 | Plasma form the second and third weeks after open colorectal resection for cancer stimulates in vitro endothelial cell growth,migration,and invasion显示文摘 | Shantha Kumara HM Kirchoff D Naffoyje S | 2012 | Surg Endosc2012，26，3： | 1 |
| 20 | Reduced cardiac conduction velocity and predisposition to arrhythmias in connexiMO deficient mice显示文摘 | Kirchoff S Nelles E Hagendorff A | 1998 | Current biology1998，8，： | 1 |
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