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| 1 | Risk factors for bleeding after endoscopic submucosal dissection of colorectal neoplasms显示文摘AIM:To investigate the risk factors for delayed bleeding following endoscopic submucosal dissection(ESD)treatment for colorectal neoplasms.METHODS:We retrospectively reviewed the medical records of 317 consecutive patients with 325 lesions who underwent ESD for superficial colorectal neoplasms at our hospital from January 2009 to June2013.Delayed post-ESD bleeding was defined as bleeding that resulted in overt hematochezia 6 h to 30d after ESD and the observation of bleeding spots as confirmed by repeat colonoscopy or a required blood transfusion.We analyzed the relationship between risk factors for delayed bleeding following ESD and the following factors using univariate and multivariate analyses:age,gender,presence of comorbidities,use of antithrombotic drugs,use of intravenous heparin,resected specimen size,lesion size,lesion location,lesion morphology,lesion histology,the device used,procedure time,and the presence of significant bleeding during ESD.RESULTS:Delayed post-ESD bleeding was found in14 lesions from 14 patients(4.3%of all specimens,4.4%patients).Patients with episodes of delayed postESD bleeding had a mean hemoglobin decrease of2.35 g/dL.All episodes were treated successfully using endoscopic hemostatic clips.Emergency surgery was not required in any of the cases.Blood transfusion was needed in 1 patient(0.3%).Univariate analysis revealed that lesions located in the cecum(P=0.012)and the presence of significant bleeding during ESD(P=0.024)were significantly associated with delayed post-ESD bleeding.The risk of delayed bleeding was higher for larger lesion sizes,but this trend was not statistically significant.Multivariate analysis revealed that lesions located in the cecum(OR=7.26,95%CI:1.99-26.55,P=0.003)and the presence of significant bleeding during ESD(OR=16.41,95%CI:2.60-103.68,P=0.003)were independent risk factors for delayed post-ESD bleeding.CONCLUSION:Location in the cecum and significant bleeding during ESD predispose patients to delayed post-procedural bleeding.Therefore,careful and additional management is recommended for these patients. | Sho Suzuki Akiko Chino Teruhito Kishihara Naoyuki Uragami Yoshiro Tamegai Takanori Suganuma Junko Fujisaki Masaaki Matsuura Takao Itoi Takuji Gotoda Masahiro Igarashi Fuminori Moriyasu | 2014 | World Journal of Gastroenterology2014，20，7： | 21 |
| 2 | Treatment strategy for rectal carcinoids: A clinicopathological analysis of 229 cases at a single cancer institution显示文摘 | Akiyoshi Kasuga Akiko Chino Naoyuki Uragami Teruhito Kishihara Masahiro Igarashi Rikiya Fujita Noriko Yamamoto Masashi Ueno Masatoshi Oya Tetsuichiro Muto | 2012 | Journal of Gastroenterology and Hepatology2012，，12： | 2 |
| 3 | Di- etary conjugated linoleic acid increases immunoglobulin productivity of Sprague - Dawley rat spleen lymphocytes 显示文摘 | YAMASAKI M KISHIHARA K MANSHO K | 2000 | Siosci Siotechnol Siochem2000，64，10： | 1 |
| 4 | Laparoscopic cholecystectomy with and without abdominal prophylactic drainage 显示文摘 | Ishikawa K Matsumta T Kishihara F et 81 | 2011 | Dig Endosc2011，23，2： | 1 |
| 5 | A recommended esterification method for gas chromatographic measurement of conjugated linoleic acid显示文摘 | Yamasaki M Kishihara K Ikeda I | 1999 | J Oil Fat Ind1999，76，8： | 1 |
| 6 | In vitro calcification in human osteobalstic cell line derived from periosteum 显示文摘 | Kishihara Y Kawamura M Oda H | 1987 | Biochem Biophys Res Co mmun1987，145，2： | 1 |
| 7 | N-3 polyunsaturated fatty acids accentuate B16 melanoma growth and metastasis through suppression of tumoricidal function of T ceils and macrophages显示文摘 | Salem ML Kishihara K Abe K | 2000 | Anticancer Res2000，，： | 1 |
| 8 | Increased prostacyclin content in gastric mucosa of cirrhotic patients with portal hypertensive gastropathy 显示文摘 | OHTA M KISHIHARA F HASHIZUME M | 1995 | Prostaglandins Leukot Essent Fatty Acids1995，53，1： | 1 |
| 9 | Effect of glucocorticoid administration on intestinal,renal,and cerebellar calbindin-D28K in chicks显示文摘 | Tohmon M Fukase M Kishihara M | 1988 | J Bone Miner Res1988，3，3： | 1 |
| 10 | Clarification of sugar solution through a dynamic membrane formed on a porous ceramic tube 显示文摘 | Kishihara S Tamaki H Fuji S | 1988 | Desalination1988，70，： | 1 |
| 11 | Superplasticity and cavitation of recycled AZ31 magnesium alloy fabricated by solid recycling process显示文摘 | Chino Y Kishihara K Shimojima K | 2002 | Mater Trans2002，43，： | 1 |
| 12 | Effective follow-up for recurrence or a second primary cancer in patients with eayly gastric cancer显示文摘 | Iketa Y Saku M Kishihara F | 2005 | Br J Surg2005，92，2： | 1 |
| 13 | Dietary conjugated linoleic acid increases immunoglobulin productivity of SpragueDawley rat spleen lymphocytes显示文摘 | Kishihara K | 2000 | Biosci Biotechnol Biochem2000，64，10： | 1 |
| 14 | Laparoseopic splenectomy for idiopathic thrombocytopenic purpura; comparison of laparoscopic surgery and conventional open surgery 显示文摘 | Hashizume M Ohta M Kishihara F | 1996 | Surg Laparosc Endosc1996，6，2： | 1 |
| 15 | Superplasticity and cavitation of recycled AZ31 magnesium Alloy fabricated by solid recycling process显示文摘 | CHINO Y KISHIHARA R SHIMOJIMA K | 2002 | Materials Transactions2002，43，10： | 1 |
| 16 | Delta1-Notch3 Interactions Bias the Functional Differentiation of Activated CD4 + T Cells显示文摘 | Yoichi Maekawa Shin-ichi Tsukumo Shigeru Chiba Hisamaru Hirai Yuki Hayashi Hiroko Okada Kenji Kishihara Koji Yasutomo | 2003 | Immunity2003，，4： | 1 |
| 17 | Suppressionof IgE production in mice treated with a traditional Chinese medi-cine,bu - zhong-yi- qi-tang显示文摘 | KANEKO M KISHIHARA K KAWAKITA T et a:l | 1997 | Immunopharmacology1997，36，1： | 1 |
| 18 | A recommended esterification method for gas chromatographic measurement of conjugated linoleic acid显示文摘 | Kishihara K Ikeda I | 1999 | JAOCS1999，76，8： | 1 |
| 19 | Effect of glucocorticoid administration on intestinal,renal,and cerebellar calbindin-D28K in chicks显示文摘 | Tohmon M Fukase M Kishihara M | 1988 | Journal of Bone and Mineral Research1988，3，3： | 1 |
| 20 | Suppression of IgE production in mice treated with a traditional Chinese medi- cine, ba - zhong - yi - qi - tang 显示文摘 | KANEKO M KISHIHARA K KAWAKITA T | 1997 | Immunopharmacology1997，36，1： | 1 |
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