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| 1 | Burden of Clostridium difficile infection between 2010 and 2013:Trends and outcomes from an academic center in Eastern Europe显示文摘AIM:To analyze the incidence and possible risk factors in hospitalized patients treated with Clostridium difficile infection(CDI).METHODS:A total of 11751 patients were admitted to our clinic between 1 January 2010 and 1 May2013.Two hundred and forty-seven inpatients were prospectively diagnosed with CDI.For the risk analysis a 1:3 matching was used.Data of 732 patients matched for age,sex,and inpatient care period and unit were compared to those of the CDI population.Inpatient records were collected from an electronic hospital database and comprehensively reviewed.RESULTS:Incidence of CDI was 21.0/1000 admissions(2.1%of all-cause hospitalizations and 4.45%of total inpatient days).The incidence of severe CDI was 12.6%(2.63/1000 of all-cause hospitalizations).Distribution of CDI cases was different according to the unit type,with highest incidence rates in hematology,gastroenterology and nephrology units(32.9,25 and24.6/1000 admissions,respectively) and lowest rates in 1.4%(33/2312) in endocrinology and general internal medicine(14.2 and 16.9/1000 admissions)units.Recurrence of CDI was 11.3%within 12 wk after discharge.Duration of hospital stay was longer in patients with CDI compared to controls(17.6 ± 10.8d vs 12.4 ± 7.71 d).CDI accounted for 6.3%of allinpatient deaths,and 30-d mortality rate was 21.9%(54/247 cases).Risk factors for CDI were antibiotic therapy[including third-generation cephalosporins or fluoroquinolones,odds ratio(OR) = 4.559;P < 0.001],use of proton pump inhibitors(OR = 2.082,P< 0.001),previous hospitaiization within 12 mo(OR = 3.167,P < 0.001),previous CDI(OR = 15.32;P < 0.001),while presence of diabetes mellitus was associated with a decreased risk for CDI(OR = 0.484;P< 0.001).Treatment of recurrent cases was significantly different from primary infections with more frequent use of vancomycin alone or in combination(P < 0.001),and antibiotic therapy duration was longer(P < 0.02).Severity,mortality and outcome of primary infections and relapsing cases did not significantly differ.CONCLUSION:CDI was accounted for significant burden with longer hospitaiization and adverse outcomes.Antibiotic,PPI therapy and previous hospitaiization or CDI were risk factors for CDI. | Zsuzsanna Kurti Barbara D Lovasz Michael D Mandel Zoltan Csima Petra A Golovics Bence D Csako Anna Mohas Lorant Gnczi Krisztina B Gecse Lajos S Kiss Miklos Szathmari Peter L Lakatos | 2015 | World Journal of Gastroenterology2015，21，21： | 6 |
| 2 | Increased duodenal expression of mi R-146a and-155 in pediatric Crohn's disease显示文摘AIM: To evaluate the role of micro RNA(mi R)-146 a,-155 and-122 in the duodenal mucosa of pediatric patients with Crohn's disease(CD) and the effect of transforming growth factor-β(TGF-β) on these mi Rs in duodenal epithelial and fibroblast cells.METHODS: Formalin-fixed, paraffin-embedded biopsies derived from the macroscopically inflamed(CD inflamed: n = 10) and intact(CD intact: n = 10) duodenal mucosa of pediatric CD patients and control children(C: n = 10) were examined. Expression of mi R-146 a,-155 and-122 was determined by realtime polymerase-chain reaction(PCR). The expression of the above mi Rs was investigated in recombinant human TGF-β(1 nmol/L, 24 h) or vehicle treated small intestinal epithelial cells(CCL-241) and primary duodenal fibroblast cells derived from healthy children as well.RESULTS: Expression of mi R-146 a was significantly higher in the inflamed duodenal mucosa compared to the intact duodenal mucosa of children with CD(CD inflamed: 3.21 ± 0.50 vs CD intact: 0.62 ± 0.26, p ≤ 0.01) and to the control group(CD inflamed: 3.21 ± 0.50 vs C: 1.00 ± 0.33, p ≤ 0.05). The expression of mi R-155 was significantly increased in the inflamed region of the duodenum compared to the control group(CD inflamed: 4.87 ± 1.02 vs Control: 1.00 ± 0.40, p ≤ 0.001). The expression of mi R-122 was unchanged in the inflamed or intact mucosa of CD patients compared to controls. TGF-β treatment significantly decreased the expression of mi R-155 in small intestinal epithelial cells(TGF-β: 0.7 ± 0.083 vs Control: 1 ± 0.09, p ≤ 0.05) and also the expression of mi R-146a(TGF-β: 0.67 ± 0.04 vs Control: 1 ± 0.15, p ≤ 0.01) and mi R-155(TGF-β: 0.72 ± 0.09 vs Control: 1 ± 0.06, p ≤ 0.05) in primary duodenal fibroblasts compared to corresponding vehicle treated controls. TGF-β treatment did not influence the expression of mi R-122.CONCLUSION: The elevated expression of mi R-146 a and-155 in the inflamed duodenal mucosa of CD patients suggests the role of these mi Rs in the pathomechanism of inflammatory bowel disease. Antiinflammatory TGF-β plays an important role in the regulation of the expression of these mi Rs. | Dániel Szucs Nóra Judit Béres Réka Rokonay Kriszta Boros Katalin Borka Zoltán Kiss András Arató Attila J Szabó ádám Vannay Erna Sziksz Csaba Bereczki Gábor Veres | 2016 | World Journal of Gastroenterology2016，22，26： | 2 |
| 3 | Prevalence and predictors of hospitalization in Crohn's disease in a prospective population-based inception cohort from 2000-2012显示文摘AIM: To analyze the prevalence, length and predictors of hospitalization in the biological era in the populationbased inception cohort from Veszprem province.METHODS: Data of 331 incident Crohn's disease(CD) patients diagnosed between January 1, 2000 and December 31, 2010 were analyzed(median age at diagnosis: 28; IQR: 21-40 years). Both in- and outpatient records were collected and comprehensively reviewed.RESULTS: Probabilities of first CD-related hospitalization and re-hospitalization were 32.3%, 45.5%,53.7% and 13.6%, 23.9%, 29.8%, respectively after one, three and five years of follow-up in Kaplan-Meier analysis. First-year hospitalizations were related to diagnostic procedures(37%), surgery or disease activity(27% and 21%). Non-inflammatory disease behavior at diagnosis(HR = 1.32, P = 0.001) and perianal disease(HR = 1.47, P = 0.04) were associated with time to first CD-related hospitalization, while disease behavior change(HR = 2.38, P = 0.002) and need for steroids(HR = 3.14, P = 0.003) were associated with time to first re-hospitalization in multivariate analyses.Early CD-related hospitalization(within the year of diagnosis) was independently associated with need for immunosuppressives(OR = 2.08, P = 0.001) and need for surgeries(OR = 7.25, P < 0.001) during the disease course.CONCLUSION: Hospitalization and re-hospitalization rates are still high in this cohort, especially during the first-year after the diagnosis. Non-inflammatory disease behavior at diagnosis was identified as the pivotal predictive factor of both hospitalization and rehospitalization. | Petra A Golovics Laszlo Lakatos Michael D Mandel Barbara D Lovasz Zsuzsanna Vegh Zsuzsanna Kurti Istvan Szita Lajos S Kiss Tunde Pandur Peter L Lakatos | 2015 | World Journal of Gastroenterology2015，21，23： | 2 |
| 4 | Effects of perinatat asphyxia on the neurobehavioral and retinal development of newborn rats显示文摘 | Kiss P Szogyi D Reglodi D | 2009 | Brain Res2009，1255，： | 1 |
| 5 | Large-scale properties of clustered networks: implications for disease dynamics显示文摘 | Green D M Kiss I Z | 2010 | Journal of Biological Dynamics2010，4，5： | 1 |
| 6 | The contribution to tidal asymmetry by different combinations of tidal constituents 显示文摘 | Song D H Wang X H Kiss A E | 2011 | Journal of Geophysical Research2011，，： | 1 |
| 7 | Review on the protective effects of PACAP in models of neurodegenerative diseases in vi- tro and in vivo显示文摘 | Reglodi D Kiss P Lubics A | 2011 | Curr Pharm Des2011，17，： | 1 |
| 8 | Quantitative MALDI tandem mass spectrometric imaging of cocaine from brain tissue with a deuterated internal standard显示文摘 | Pirman D A Reich R F Kiss A | 2013 | Analytical Chemistry2013，85，2： | 1 |
| 9 | Simple Models for Assessing Migration from Food-packaging Films显示文摘 | CHUNG D PAPADA KISS E | 2002 | Food Additives and Contaminants2002，19，6： | 1 |
| 10 | Stable high-order delta-sigma digital-to-analog converters显示文摘 | Kiss P Arias J Li D | 2004 | IEEE Trans Circ and Syst2004，51，1： | 1 |
| 11 | Tracking of the kinetic stability of 2 types of total nutrient admixtures containing different lipid emulsions 显示文摘 | Balogh J Kiss D Dredan J | 2006 | AAPS Pharm Sci Tech2006，7，4： | 1 |
| 12 | A distinct sequence in the adenine nucleotide translocase from Artemia fran-ciscana embryos is associated with insensitivity to bongkr-ekate and atypical effects of adenine nucleotides on Ca2+ uptake and sequestration 显示文摘 | Konràd C Kiss G T-r-csik B | 2011 | FEBS J2011，278，82： | 1 |
| 13 | IL - 12 receptor betal and Toll - like rececptor 4 increase IL - 1 beta and IL - 18 - associated myocarditis and coxsackievirus replication 显示文摘 | Fairweather D Yusung S Frisaneho - Kiss S | 2003 | J Immunol2003，170，9： | 1 |
| 14 | Importance of ambulatory blood pressure monitoring in adolescent hypertension显示文摘 | Pall D Kiss I Katona E | 2012 | Kidney Blood Press Res2012，35，2： | 1 |
| 15 | Contribution of the neural cell adhesion molecule to neuronal and synaptic plasticity显示文摘 | Kiss JZ Muller D | 2001 | Rev Neuro Sci2001，12，4： | 1 |
| 16 | The effect of tra-cheostomy timing during critical illness on long-term sur-vival显示文摘 | Scales DC Thiruchelvam D Kiss A | | 0，，09： | 1 |
| 17 | Contribution of the neural cell adhesion molecule to neuronal and synaptic plasticity显示文摘 | Alex D | 2001 | Rev Iburosci2001，12，4： | 1 |
| 18 | Contribution of the neural cell adhesionmolecule to neuronal and synaptic plasticity显示文摘 | Kiss JZ Muller D | | 0，，04： | 1 |
| 19 | Music in the endoscopy suite:a meta-analysis of randomized controlled studies显示文摘 | Kiss A Wetz RV | 2007 | Endoscopy2007，39，6： | 1 |
| 20 | Evidence for an accessory protein function for Toll - like receptor 1 in anti- bacterial response显示文摘 | WYLLIE D H KISS - TOTH E VISINTIN A | 2000 | J Immunol2000，165，12： | 1 |
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