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| 1 | Epac2-deficiency leads to more severe retinal swelling, glial reactivity and oxidative stress in transient middle cerebral artery occlusion induced ischemic retinopathy显示文摘Ischemia occurs in diabetic retinopathy with neuronal loss, edema, glial cell reactivity and oxidative stress. Epacs, consisting of Epac1 and Epac2, are c AMP mediators playing important roles in maintenance of endothelial barrier and neuronal functions. To investigate the roles of Epacs in the pathogenesis of ischemic retinopathy, transient middle cerebral artery occlusion(t MCAO) was performed on Epac1-deficient(Epac1-/-) mice, Epac2-deficient(Epac2-/-) mice, and their wild type counterparts(Epac1+/+ and Epac2+/+). Two-hour occlusion and 22-hour reperfusion were conducted to induce ischemia/reperfusion injury to the retina. After t MCAO, the contralateral retinae displayed similar morphology between different genotypes. Neuronal loss, retinal edema and increase in immunoreactivity for aquaporin 4(AQP4), glial fibrillary acidic protein(GFAP), peroxiredoxin 6(Prx6) were observed in ipsilateral retinae. Epac2-/- ipsilateral retinae showed more neuronal loss in retinal ganglion cell layer, increased retinal thickness and stronger immunostaining of AQP4, GFAP, and Prx6 than those of Epac2+/+. However, Epac1-/- ipsilateral retinae displayed similar pathology as those in Epac1+/+ mice. Our observations suggest that Epac2-deficiency led to more severe ischemic retinopathy after retinal ischemia/reperfusion injury. | LIU Jin YEUNG Patrick Ka Kit CHENG Lu LO Amy Cheuk Yin CHUNG Stephen Sum Man CHUNG Sookja Kim | 2015 | Science China(Life Sciences)2015，58，6： | 12 |
| 2 | A low-carbon oriented probabilistic approach for transmission expansion planning显示文摘Following the deregulation of the power industry,transmission expansion planning(TEP)has become more complicated due to the presence of uncertainties and conflicting objectives in a market environment.Also,the growing concern on global warming highlights the importance of considering carbon pricing policies during TEP.In this paper,a probabilistic TEP approach is proposed with the integration of a chance constrained load curtailment index.The formulated dynamic programming problem is solved by a hybrid solution algorithm in an iterative process.The performance of our approach is demonstrated by case studies on a modified IEEE 14-bus system.Simulation results prove that our approach can provide network planners with comprehensive information regarding effects of uncertainties on TEP schemes,allowing them to adjust planning strategies based on their risk aversion levels or financial constraints. | Jing QIU Zhaoyang DONG Junhua ZHAO Ke MENG Fengji LUO Kit Po WONG Chao LU | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，1： | 8 |
| 3 | Lyso- phosphatidic acid up-regulates expression of growth-regulated oncogene-alpha, interleuldn-8, and monocyte chemoattractant protein-1 in human first-trimester trophoblasts:possible roles in angiogenesis and immune regulation 显示文摘 | Chen SU Chou CH Chao Kit Lee H Lin CW Lu HF | 2010 | Endocrinology2010，151，1： | 1 |
| 4 | Epidemiology,outcomes,and risk factors of invasive fungal infections in adult patients with acute mydoge- nous leukemia after induction chemotherapy显示文摘 | Dionissios N Kit Lu Amy H | 2013 | Diagn Microbiol Infect Dis2013，75，2： | 1 |
| 5 | Unexpected Electronic Behavior of Organic Azide and Metal-Carbynein Their 1,3-Dipolar Cycloaddition Reaction显示文摘of main obsevation and conclusion 1,3-Dipolar aycloaddition reaction between organic azide and metal carbyne is a useful strategy to con-struct metallacycles.However,the electronic behavior of organic azide in 1,3-dipolar aycloaddition reactions is less explored.Tthis work revealed theunexpected role of organic azide as electrophiles in its cycloaditions with various metal carbynes.The feasility and regioselectivity of a Fischer-typeosmiun carbyne in its reaction with an organic azide are explained by the increased nucleophilicity of carbyne carbon upon bending. | Jing-Xuan Zhang Fu Kit Sheong Zhengyu Lu Hong Zhang Zhenyang Lin | 2020 | Chinese Journal of Chemistry2020，38，12： | 1 |
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