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| 1 | Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease显示文摘The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD. | Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele | 2009 | World Journal of Gastroenterology2009，15，10： | 20 |
| 2 | Immunological response in alcoholic liver disease显示文摘The development of alcoholic liver disease (ALD) can be attributed to many factors that cause damage to the liver and alter its functions. Data collected over the last 30 years strongly suggests that an immune component may be involved in the onset of this disease. This is best evidenced by the detection of circulating autoantibodies, infiltration of immune cells in the liver, and the detection of hepatic aldehyde modified proteins in patients with ALD. Experimentally, there are numerous immune responses that occur when proteins are modified with the metabolites of ethanol. These products are formed in response to the high oxidative state of the liver during ethanol metabolism, causing the release of many inflammatory processes and potential of necrosis or apoptosis of liver cells. Should cellular proteins become modified with these reactive alcohol metabolites and be recognized by the immune system, then immune responses may be initiated. Therefore, it was the purpose of this article to shed some insight into how the immune system is involved in the development and/or progression of ALD. | Michael J Duryee Lynell W Klassen Geoffrey M Thiele | 2007 | World Journal of Gastroenterology2007，13，37： | 9 |
| 3 | At- mospheric Corrosivity Modeling-A Review显示文摘 | ROBERGE P R KLASSEN R D HABERECHT P W | 2002 | Materials & Design2002，23，3： | 1 |
| 4 | 显示文摘 | Klassen T Oelerich W | 1999 | International Journal of Hydrogen Energy1999，24，： | 1 |
| 5 | Human chorionic somatomammotropin and growth hormone gene expression in rat pituitary tumour cells is dependent on proximal promoter sequences 显示文摘 | Nachigal M W Nickel B E Klassen M E | 1989 | Nucl Acids Res1989，17，： | 1 |
| 6 | Turbulence statistics in a fire room model by large eddy simulation显示文摘 | Zhang W Hamer A Klassen M | 2002 | Fire Safety Journal2002，37，： | 1 |
| 7 | Immunologic mechanisms of alcoholic liver injury显示文摘 | THIELE G M FREEMAN T L KLASSEN L W | 2004 | Semin Liver Dis2004，24，3： | 1 |
| 8 | Atmospheric Corrosivity Modeling a Review 显示文摘 | ROBERGE P R KLASSEN R D HABERECHT P W | 2002 | Materials & Design2002，23，3： | 1 |
| 9 | Turbulence statistics in a fire room model by large eddy simulation 显示文摘 | ZHANG W HAMER A KLASSEN M | 2002 | Fire Safety Journal2002，37，8： | 1 |
| 10 | Atmospheric Corrosively Modeling-a Review 显示文摘 | Roberge P R Klassen R D Haberecht P W | 2002 | Materials and Design2002，23，： | 1 |
| 11 | Geology and paleontology of Pleistocene deposits in Southwestern Manitoba显示文摘 | Klassen R W Delorme L D | 1967 | Canadian Journal of Earth Sciences1967，4，： | 1 |
| 12 | The empact CVT:modelling,simulation and experiments显示文摘 | Klassen T W G L Bonsen B Meerakker K G O V | 2008 | International Journal of Modelling Identification and Control2008，3，3： | 1 |
| 13 | Comparisons of selenite and selenium yeast feed supplements on Se-incorporation, mastitis and leukocyte function in se-eficient dairy cows 显示文摘 | Malbe M Klassen M Fang W | 1995 | J Vet Med (series A)1995，42，： | 1 |
| 14 | Can psychological factors ac- count for a lack of nocturnal blood pressure dipping? 显示文摘 | Linden W Klassen K Phillips M | 2008 | Ann Behav Med2008，36，3： | 1 |
| 15 | Metal oxides as catalysts for improved hydrogen sorption in nanoctystalline Mg-based mate- rials 显示文摘 | Oelerich W Klassen T Bormann R | 2001 | Journal of Alloys and Compounds2001，315，： | 1 |
| 16 | The phar- macokinetic responses of humans to 20 g of alanyL-gluta- mine dipeptide differ with the dosing protocol but not with gastric acidity or in patients with acute enguefever显示文摘 | Klassen P Mazariegos M Solomons N W | 2000 | J Nutr2000，130，2： | 1 |
| 17 | Metal oxides as cata- lysts for improved hydrogen sorption in nanocrystalline Mg based materials 显示文摘 | Oelerich W Klassen T Bormann R | 2001 | Journal of Alloys and Compounds2001，315，12： | 1 |
| 18 | Metal oxide as catalysts for improved hydrogen sorption in nanocrystalline Mg-based materials显示文摘 | Klassen T Bormann R | 2001 | J Alloys Comp2001，315，： | 1 |
| 19 | Nitric oxide inhibition impairs blood flow during exercise in hearts with a collateral-dependent myocardial region显示文摘 | Traverse J H Kinn J W Klassen C | 1998 | J Am Coll Cardiol1998，31，1： | 1 |
| 20 | Design and field evaluation of a new controller for soil-water based irri- gation显示文摘 | Mufioz-Carpena R Dukes M D Li Y Klassen W | 2008 | Applied Engineering in Agriculture2008，24，2： | 1 |
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