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| 1 | Neuroendocrine differentiation:The mysterious fellow of colorectal cancer显示文摘Neuroendocrine differentiation in sporadic colorectal cancer has been recognized since decades, but its clinical impact is still controversially discussed. Detailed parameter analyses hint at the possibility that probablynot neuroendocrine differentiation itself, but its association with poor grade of tumor differentiation, lymph node metastases, distant metastases and other unfavorable features contribute to worse clinical outcome. However, other studies deny a relationship between neuroendocrine differentiation and prognosis of colorectal cancer. This review elucidates, whether new insights into the origin of neuroendocrine differentiation in the intestinal epithelium, its regulation by m TOR pathway components and its possible link to the intestinal stem cell compartment could determine a role of neuroendocrine cells as prognostic marker and putative therapeutic target in sporadic colorectal cancer. | Britta Kleist Micaela Poetsch | 2015 | World Journal of Gastroenterology2015，21，41： | 3 |
| 2 | Human enamel thickness and ENAM polymorphism显示文摘The tooth enamel development gene, enamelin(ENAM), showed evidence of positive selection during a genome-wide scan of human and primate DNA for signs of adaptive evolution. The current study examined the hypothesis that a single-nucleotide polymorphism(SNP) C14625T(rs7671281) in the ENAM gene identified in the genome-wide scan is associated with a change in enamel phenotype. African Americans were selected as the target population, as they have been reported to have a target SNP frequency of approximately 50%, whereas non-Africans are predicted to have a 96% SNP frequency. Digital radiographs and DNA samples from 244 teeth in 133 subjects were analysed, and enamel thickness was assessed in relation to SNP status,controlling for age, sex, tooth number and crown length. Crown length was found to increase with molar number, and females were found to have thicker enamel. Teeth with larger crowns also had thicker enamel, and older subjects had thinner enamel.Linear regression and generalized estimating equations were used to investigate the relationship between enamel thickness of the mandibular molars and ENAM SNP status; enamel in subjects with the derived allele was significantly thinner(P = 0.040)when the results were controlled for sex, age, tooth number and crown length. The derived allele demonstrated a recessive effect on the phenotype. The data indicate that thinner dental enamel is associated with the derived ENAM genotype. This is the first direct evidence of a dental gene implicated in human adaptive evolution as having a phenotypic effect on an oral structure. | Diane M Daubert Joanna L Kelley Yuriy G Udod Carolina Habor Chris G Kleist Ilona K Furman Igor N Tikonov Willie J Swanson Frank A Roberts | 2016 | International Journal of Oral Science2016，8，2： | 2 |
| 3 | Application of scanning UV microspectrophotometry to localise lignins and phenolic extractives in plant cell walls显示文摘 | Koch G Kleist G | 2001 | Holzforschung2001，55，： | 1 |
| 4 | The Relation-ship of Drought Frequency and Duration To Time Scales显示文摘 | Mckee T B Doesken N J Kleist J | 1993 | California- Eighth Conference on Ap- plied Climatology1993，，： | 1 |
| 5 | Detection of new PTENPMMACI mutations in head and neck squamous cell carcinomas with loss of chromosome 10显示文摘 | Poetsch M Lorenz G Kleist B | 2002 | Cancer Genet Cytogenet2002，132，1： | 1 |
| 6 | Favourable effect of flunarizine on the recovery form hemiparesis in rats with intracerebral hematomas 显示文摘 | Kleist B van Reempts J van Deuren B | 1989 | Neurosci Lett1989，103，： | 1 |
| 7 | Application of scanning UV microspectroscopy to localise lignins and phenolic extractives in plant cell walls显示文摘 | Koch G Kleist G | 2001 | Holzforschung2001，，55： | 1 |
| 8 | Application of scanning UV microspectrophoto-metry to localise lignins and phenolic extractives in plant cell walls显示文摘 | Koch G Kleist G | 2005 | Holzforschung2005，55，6： | 1 |
| 9 | Lacking prognostic significance of beta 2-microglobulin,MHC class I and class II antigen expression in breast carcinomas显示文摘 | Wintzer H O Benzing M von Kleist S | | 0，，02： | 1 |
| 10 | Surgical decompression for traumatic brain swelling and results显示文摘 | Kleist W Gaab MR Dlets H | 1999 | J Neurosurg1999，90，2： | 1 |
| 11 | Aerobic epoxidation of olefins catalyzed by the cobalt-based metal-organic Framework STA-12(Co)显示文摘 | BEIER M J KLEIST W WHARMBY M T | 2012 | Chemistry-A European Journal2012，18，3： | 1 |
| 12 | Interferon gamma and Interleukin-2 secretion in whole blood cultures from small- cell lung cancer patients显示文摘 | Szopinski J yon Kleist S Rowinska-Zakrzewska E | 2001 | Tumour Biol2001，22，2： | 1 |
| 13 | Comparison of neuroendo- crine differentiation and KRAS/NRAS/BRAF/PIK3CA/TP53 mu- tation status in primary and metastatic colorectal cancer显示文摘 | Kleist B Kempa M Novy M | 2014 | Int J Clin Exp Pathol2014，7，9： | 1 |
| 14 | An approach to evaluating e-business information systems projects显示文摘 | | 2003 | Information Systems Frontiers2003，5，3： | 1 |
| 15 | Gastroinleslinal stromal tumor and gastric adenocarcinoma collision tumors显示文摘 | Kleist B Lasota J Miettinen M | 2010 | Hum Pathol2010，41，7： | 1 |
| 16 | Overexpression of the phy- tase from Escherichia coli and its extracellular production in bioreactors显示文摘 | Miksch G Kleist S Friehs K | 2002 | Applied microbiology and biotechnology2002，59，： | 1 |
| 17 | Clear cell chondrosarcoma of the larynx : a case report of a rare histologic variant in an uncommon localization显示文摘 | Kleist B Poetsch M Lang C | 2002 | Am J Surg Pathol2002，26，3： | 1 |
| 18 | Modulation of major histocompatibility complex (MHC)expression by interferons and microbial agents显示文摘 | Joller P Kleist R | 1998 | Scand J Immunol1998，28，2： | 1 |
| 19 | Release of lipoxygenase products and monoterpenes by tomato plants as an indicator of Botrytis cinerea-induced stress显示文摘 | Jansen R M C Miebach M Kleist E | 2009 | Plant Biology2009，11，6： | 1 |
| 20 | Overexpression of the phytase from Escherichia coli and its extracellular production in bioreactors 显示文摘 | Miksch G Kleist S Friehs K | 2002 | Appli Microbiol and Biotechnol2002，59，6： | 1 |
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