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	题名	作者	年代	出处	被引量
1	Involvement of eicosanoids in the pathogenesis of pancreatic cancer: the roles of cyclooxygenase-2 and 5-lipoxygenase显示文摘The interplay between inflammation and cancer progression is a growing area of research. A combination of clinical, epidemiological, and basic science investigations indicate that there is a relationship between inflammatory changes in the pancreas and neoplastic progression. Diets high in ω-6 polyunsaturated fatty acids provide increased substrate for arachidonic acid metabolism by cyclooxygenase-2(COX-2) and 5-lipoxygenase(5-LOX) to form eicosanoids. These eicosanoids directly contribute to pancreatic cancer cell proliferation. Both COX-2 and 5-LOX are upregulated in multiple cancer types, including pancreatic cancer. In vitro studies using pancreatic cancer cell lines have demonstrated upregulation of COX-2 and 5-LOX at both the mRNA and protein levels. When COX-2 and 5-LOX are blocked via a variety of mechanisms, cancer cell proliferation is abrogated both in vitro and in vivo.The mechanism of COX-2 has been shown to include effects on apoptosis as well as angiogenesis. 5-LOX has been implicated in apoptosis. The use of COX-2 and 5-LOX inhibitors in clinical studies in patients with pancreatic cancer has been limited. Patient enrollment has been restricted to those with advanced disease which makes evaluation of these drugs as chemopreventive agents difficult. COX-2 and 5-LOX expression have been shown to be present during the early neoplastic changes of pancreatic cancer, well before progression to invasive disease. This indicates that the ideal role for these interventions is early in the disease process as preventive agents, perhaps in patients with chronic pancreatitis or hereditary pancreatitis.	Lawrence M Knab Paul J Grippo David J Bentrem	2014	World Journal of Gastroenterology2014，20，31：	9
2	Leg ulcers in a pa- tient associated with hydroxyurea therapy 显示文摘	Dissemond J Hoeft D Knab J	2006	Int J Der- mato12006，45，2：	1
3	Protein dynami- cal transition in terahertz dielectric response 显示文摘	Markelz A G Knab J R Chen J Y	2007	Chemical Physics Letters2007，442，：	1
4	Push-pull sorbent-based pheresis and hemodiabsorption in the treatment of hepatic failure: preliminary results of a clinical trial with the BioLogic-DTPF System显示文摘	Ash SR Steczko J Knab WR	2000	Ther Apher2000，4，：	1
5	Biomarker indicators for anaerobic oxidizers of methane in brackish-marine sediments with diffusive methane fluxes显示文摘	Aquilina A Knab N J Knittel K	2010	Organic Geochemistry2010，41，4：	1
6	Interpolation of band-limited functions using the approximate prolate series显示文摘	KNAB J J	1979	IEEE Trans Inform Theory (Corres)1979，25，6：	1
7	Microbial ecology of the dark ocean above,at,and below the seafloor显示文摘	Orcutt BN Sylvan JB Knab N J		0，，02：	1
8	Interpolation of bandlimited functions using the approximate prolate series显示文摘	Knab J J	1979	IEEE Transactions on Information Theory1979，25，6：	1
9	Interpolation of band-limited functions using the approximate prolate series 显示文摘	KNAB J J	1979	IEEE Trans Inform Theory (Cortes)1979，25，6：	1
10	Interpolation of band-limited functions using the approximate prolate series显示文摘	KNAB J J	1979	IEEE Trans Inform Theory (Corres)1979，25，6：	1
11	Leg ulcer in a patient associated with hydroxyurea therapy显示文摘	Dissemond J Hoeft D Knab J	2006	Int J Dermatol2006，45，2：	1
12	Evidence of Protein Collective Motions on the Picosecond Timescale显示文摘	He Y F Chen J Y Knab J R		0，，04：	1
13	Push-pull sorbent-based pheresis and hemodiabsorption in the treament of hepatic failure:preliminary results of a clinical trial with the BioLogic-DTPF System显示文摘	Ash SR Steczko J Knab WR		0，，：	1
14	Apparent diffusion coefficient decreases and magnetic resonance imaging perfusion parameters are associated in ischemic tissue of acute stroke patients显示文摘	Fiehler J Knab R Reichenbach JR	2001	J Cereb Blood Flow Metab2001，21，：	1
15	Apparent diffusion coefficient decreases and magnetic resonance imaging perfusion parameters are associated in ischemic tissue of acute stroke patients显示文摘	Fiehler J Knab R Reichenbach JR	2001	J Cereb Blood Flow Metab2001，21，：	1
16	Protein dynamical transition in terahertz dielectric response显示文摘	Markelz A G Knab J R Chen J Y	2007	Chemical Physics Letters2007，442，：	1
17	Thermodynamic and kinetic control on anaerobic oxidation of methane in marine sedi- ments显示文摘	Knab N J Dale A W Lettmann K	2008	Geochimica et Cosmochimica Acta2008，72，15：	1
18	Push-pull sorbent-based pheresis and hemodiabsorption in the treatment of hepatic failure: preliminary results of a chnical trial with the BioLogic-DTPF system显示文摘	Ash SR Steczko J Knab WR	2000	Ther Apher2000，4，3：	1
19	Diversity and abundance of sulfate-reducing microorganisms in the sulfate and meth- ane zones of a marine sediment, Black Sea 显示文摘	Leloup J Loy A Knab N J al	2007	Environ- mental Microbiology2007，9，1：	1
20	Apparent diffusion coeffi-cient decreases and magnetic resonance imaging perfusion parame- ters are associated in ischemic tissue of acute stroke patients显示文摘	Fiehler J Knab R Reichenbach JR	2001	J Cereb Blood Flow Metab2001，21，：	1

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