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| 1 | Proposed approach to the challenging management of progressive gastroesophageal reflux disease显示文摘The progression of gastroesophageal reflux disease(GERD) in patients who are taking proton pump inhibitors(PPIs) has been reported by several investigators,leading to concerns that PPI therapy does not address all aspects of the disease.Patients who are at risk of progression need to be identified early in the course of their disease in order to receive preventive treatment.A review of the literature on GERD progression to Barrett's esophagus and the associated physiological and pathological changes was performed and risk factors for progression were identified.In addition,a potential approach to the prevention of progression is discussed.Current evidence shows that GERD can progress;however,patients at risk of progression may not be identified early enough for it to be prevented.Biopsies of the squamocolumnar junction that show microscopic intestinalization of metaplastic cardiac mucosa in endoscopically normal patients are predictive of future visible Barrett's esophagus,and an indicator of GERD progression.Such changes can be identified only through biopsy,which is not currently recommended for endoscopically normal patients.GERD treatment should aim to prevent progression.We propose that endoscopically normal patients who partially respond or do not respond to PPI therapy undergo routine biopsies at the squamocolumnar junction to identify histological changes that may predict future progression.This will allow earlier intervention,aimed at preventing Barrett's esophagus. | Joachim Labenz Parakrama T Chandrasoma Laura J Knapp Tom R DeMeester | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，9： | 7 |
| 2 | FK506 treatment inhibits caspase-3 activation and promotes oligodendroglial survival following traumatic spinal cord injury显示文摘 | Nottingham S Knapp P Springer J | 2002 | Exp Neurol2002，177，1： | 1 |
| 3 | Hydrodynamic delivery 显示文摘 | AL-DOSARI M S KNAPP J E LIU D | 2005 | Adv Genet2005，54，： | 1 |
| 4 | Inhibitors of HMG-Coa reductase sensitize human smooth muscle ceils to Fas-ligand and cytokine-induced cell death 显示文摘 | Knapp AC Huang J Starling G | 2000 | Atherosclerosis2000，152，1： | 1 |
| 5 | Conformal dome correction with counterrotating phase plates 显示文摘 | SPARROLD S W Mills J P Knapp D J et at | 2000 | Opt Eng2000，39，： | 1 |
| 6 | Digestion of biological materials using the microwave-assisted sample combustion technique 显示文摘 | Mesko M F Moraes D P Barin J S Dressler V L Knapp G Flores E M M | 2006 | Microchem Journal2006，82，： | 1 |
| 7 | Dehydrogenation of 2- imidazolines to imidazoIes with barium mangante 显示文摘 | Hughey J L Knapp S Schugar H | 1980 | Synthesis1980，6，： | 1 |
| 8 | Mortality at 12 and 24 months after stroke may be associated with depressive symptoms at 1 month显示文摘 | House A Knapp P Bamford J | 2001 | Stroke2001，32，： | 1 |
| 9 | Serotonin transporter binding in Tourette Syndrome显示文摘 | Muller-Vahl KR Meyer G J Knapp WH | 2005 | Neurosci Lett2005，385，2： | 1 |
| 10 | The fine structure obliquely striated body wall muscles in the earthworm,Lumbricus terrestris显示文摘 | Knapp M F | 1970 | Journal of Cell Science1970，，7： | 1 |
| 11 | Application of microwave induced combustion in closed vessels for carbon black-containing elastomers decomposition 显示文摘 | Moraes D P Mesko M F Mello P A Paniz J N G Dressler V L Knapp G Flores E M M | 2007 | Spectrochim Acta : Part B2007，62，： | 1 |
| 12 | Polymorphisms in interferon-induced genes and the outcome of hepatitis C virus infection:roles of MxA,OAS-1 and PKR显示文摘 | Knapp S Yee L J Frodsham A J | 2003 | Genes Immun2003，4，： | 1 |
| 13 | Modulation of di- versity by grazing and mowing in native tall-grass prairie显示文摘 | Collins S L Knapp A K Briggs J M | 1998 | Science1998，280，5364： | 1 |
| 14 | In vitro antimicrobial studies of silver carbene complexes : activity of free and nanopar- ticle carbene formulations against clinical isolates of pathogenic bacteria 显示文摘 | Leid J G Ditto A J Knapp A | 2012 | J Antimicrob Chemother2012，67，1： | 1 |
| 15 | The fine structure obliquely striated body wall muscles in the earthworm,Lumbricus terrestri 显示文摘 | Knapp M F | 1970 | Journal of Cell Science1970，，7： | 1 |
| 16 | Miniature vapor-cell atomic frequency references显示文摘 | KITCHING J KNAPPE S HOLLBERG L | 2002 | Applied Physics Letters2002，81，： | 1 |
| 17 | Fate and effects of enrofloxacin in aquatic systems under different light conditions 显示文摘 | Knapp C W Cardoza L A Hawes J N | 2005 | Environmental Science & Technology2005，39，23： | 1 |
| 18 | Serotonin transporter binding in Tourette Syndrome显示文摘 | Muller-Vahl KR Meyer G J Knapp WH | 2005 | Neurosci Lett2005，385，2： | 1 |
| 19 | Should possible recurrence of disease contraindicate liver transplantation in patients with end-stage alveolar echinococcosis? A 20-year follow-up study显示文摘 | Bresson-Hadni S Blagosklonov O Knapp J | 2011 | Liver Transpl2011，17，： | 1 |
| 20 | Anxiety disorders before birth and self-perceived distress during pregnancy:associations with maternal depression and obstetric,neonatal and early childhood outcomes显示文摘 | Martini J Knappe S Beesdo-baum K | 2010 | Early Hum Dev2010，86，5： | 1 |
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