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	题名	作者	年代	出处	被引量
1	Estrogen-mediated downregulation of HIF-1αsignaling in B lymphocytes influences postmenopausal bone loss显示文摘In the bone marrow, B cells and bone-resorbing osteoclasts colocalize and form a specific microenvironment. How B cells functionally influence osteoclasts and bone architecture is poorly understood. Using genetically modified mice and highthroughput analyses, we demonstrate that prolonged HIF-1α signaling in B cells leads to enhanced RANKL production and osteoclast formation. In addition, deletion of HIF-1α in B cells prevents estrogen deficiency-induced bone loss in mice.Mechanistically, estrogen controls HIF-1α protein stabilization through HSP70-mediated degradation in bone marrow B cells.The stabilization of HIF-1α protein in HSP70-deficient bone marrow B cells promotes RANKL production and osteoclastogenesis.Induction of HSP70 expression by geranylgeranylacetone(GGA) administration alleviates ovariectomy-induced osteoporosis.Moreover, RANKL gene expression has a positive correlation with HIF1 A expression in human B cells. In conclusion, HIF-1αsignaling in B cells is crucial for the control of osteoclastogenesis, and the HSP70/HIF-1α axis may serve as a new therapeutic target for osteoporosis.	Xianyi Meng Zhen Lin Shan Cao Iga Janowska Koshiro Sonomoto Darja Andreev Knab Katharina Jinming Wen Karl Xaver Knaup Michael Sean Wiesener Gerhard Krönke Marta Rizzi Georg Schett Aline Bozec	2022	Bone Research2022，10，2：	6
2	On Educating about Medical Data Management-The Other Side of the Electronic Health Record显示文摘	Haux R Knaup P Leiner F	2007	Methods Inf Med2007，46，1：	1
3	Estradiol and Progesterone Strongly Inhibit the Innate Immune Response of Mononuclear Cells in Newborns显示文摘	Eric Giannoni Laurence Guignard Marlies Knaup Reymond	2011	Infect Immun2011，79，7：	1
4	Can open EHR Archetypes Empower Multi-Centre Clinical Research?显示文摘	GaMe S Knaup P Schuler T	2005	Stud Health Technol Inform2005，116，：	1
5	Can openEHR Archetypes Empower Multi- Centre Clinical Research? 显示文摘	Garde S Knaup P Schuler T	2005	Stud Health Technol Inform2005，116，：	1
6	A robust geometry estimation method for spiral, sequential and circular cone-heam micro-CT显示文摘	Sawall S Knaup M Bronnikov M K	2012	Medical Physics2012，39，9：	1
7	Chondrogenic differentiation of growth factor-stimulated precursor cells in cartilage repair tissue is associated with increased HIF-1 alpha activity 显示文摘	Gelse K Mtihle C Knaup K	2008	Osteoarthritis Cartilage2008，16，2：	1
8	Investigating the dosimetfic and tumor control Consequences of prostate seed loss and migration显示文摘	Knaup C Mavroidis P Esquivel C	2012	Med Phys2012，39，：	1
9	Hyperfast parallel-beam and conebeam backprojection using the cell general Purpose hardware显示文摘	KACHELRIEB M KNAUP M		0，，04：	1
10	Factor XI regulates pathological thrombus formation on acutely ruptured ath- erosclerotic plaques 显示文摘	van Monffoort M L Kuijpers M J Knaup V L	2014	Arterioscler Thromb Vasc Biol2014，34，8：	1
11	HIF-1 or HIF-2 induction is sufficient to achieve cell cycle arrest in NIH3T3 mouse fibroblasts independent from hypoxia显示文摘	Thomas Hackenbeck Karl Xaver Knaup Ruth E. Schietke Johannes Sch?del Carsten Willam Xiaoqing Wu Christina Warnecke Kai-Uwe Eckardt Michael Wiesener	2009	Cell Cycle2009，，9：	1
12	Medical informatics at Hei-delberg/Heilbronn : status - evaluation - new challenges in a spe-cialised curriculum for medical informatics after thirty years of evo-lution 显示文摘	Leven FJ P Knaup’D Schmidt	2004	Int J Med Inforai2004，73，2：	1
13	Urine screening for gonococcal and chlamydial infections at community - based organizations in a high -morbidity area显示文摘	Jones CA Knaup RC Hayes M	2000	Sex Transm Dis2000，27，3：	1
14	On educating about medical data man agement -the other side of the electronic health record 显示文摘	Haux R Knaup P Leiner F	2007	Methods Inf Med2007，46，1：	1
15	Chondrogenic diferentiation of growth factor-stimulated precursor cells in cartilage repair tissue is associated with increased HIF-1alpha activity显示文摘	Gelse K Muhle C Knaup K	2008	Osteoarthritis Cartilage2008，16，12：	1
16	Effect of recombinant ADAMTS-13 on micmthrombis and brain injury after experimental subarachnoid hemorrhage显示文摘	Vergouwen M D Knaup V L Roelofs J J	2014	J Thromb Haemost2014，12，6：	1
17	Urine screning for gonocooccal and chlamydial infections at community-based organizations in a high-morbidity area显示文摘	Jones CA Knaup RC Hayes M	2000	Sex Transm Dis2000，27，3：	1
18	Urine screening for gonoccal and Chlamydial infection at communlty-based organizations in a high-mobidity area显示文摘	Jones CA Knaup RC Hayes M	2000	Sex Transm Dis2000，27，3：	1
19	Human intestinal hydrolysis of phenol glycosides:a study with quercetin and p-nitrophenol glyco- sides using ileostomy fluid 显示文摘	Knaup B Kahle K Erk T	2007	Mol Nutr Food Res2007，51，11：	1
20	HIF-1 or HIF-2 in- duction is sufficient to achieve cell cycle arrest in NIH3T3 mouse fibroblasts independent from hypoxia显示文摘	Hackenbeck T Knaup KX Schietke R	2009	Cell Cycle2009，8，9：	1

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