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| 1 | Interferon therapy in hepatitis Cleading to chronic type 1 diabetes显示文摘AIM: To review the prevalence,clinical data and course of interferon-associated type 1 diabetes in chronic hepatitis C virus(HCV) infection.METHODS: Search of all interferon(INF)-related type 1diabetes mellitus(T1DM) cases published in the English literature from 1992 to December 2013 according to the key words: chronic hepatitis C infection,diabetes mellitus type 1,insulin dependent diabetes mellitus,and interferon treatment.We found 107 cases and analyzed their clinical and laboratory data and long-term followup.Due to the predominance of cases described in Japanese literature,we analyzed separately cases of Caucasian and Japanese origin.In addition we describe a representative case with HCV who developed INFrelated T1 DM.RESULTS: Our data show that INF treatment increases the risk of developing T1 DM by 10-18 fold compared with the corresponding general population and the median age of onset was 43 years(range: 24-66 years) in Caucasians and 52 years(range: 45-63 years) in Japanese.Most patients developed T1 DM during INF treatment,after a median time-period of 4.2 and 5.7 mo in Caucasian and Japanese groups,respectively.The clinical course was characterized by a fulminant course with abrupt severe hyperglycemia or ketoacidosis,a high titer of anti-islet autoantibodies and almost all patients(105/107) permanently required insulin therapy with a follow-up of up to 4 years.A substantial number of patients had evidence for other autoimmune disorders mainly thyroid diseases(25% and 31% in Caucasian and Japanese groups,respectively).CONCLUSION: INF-associated T1 DM in HCV has a fulminant course,often associated with other autoimmune diseases,and results almost inevitably in permanent insulin therapy requirement. | Taiba Zornitzki Stephen Malnick Lyudmila Lysyy Hilla Knobler | 2015 | World Journal of Gastroenterology2015，21，1： | 17 |
| 2 | Metabolic regulation by protein tyrosine phosphatases显示文摘肥胖和新陈代谢的症候群和他们的联系病态是主要公共健康问题,谁的流行将继续在可预见的未来增加。为 leptin 和胰岛素的由受体的异常发信号在新陈代谢的症候群的开发起一个枢轴的作用。这两条关键发信号小径怎么被调整的更完全的分子水平的理解为肥胖,新陈代谢的症候群,和类型 II 的完整的描述是必要的糖尿病,并且为为这些疾病开发新奇处理。酷氨酸残余上的蛋白质的 Phosphorylation 在调停起一个关键作用他们的目标房间上的 leptin 和胰岛素的效果。这里,我们讨论蛋白质酷氨酸磷酸酶,是在 vivo 的蛋白质 phosphorylation 的关键生理的管理者,由假装在他们的主要目标纸巾由 leptin 和胰岛素受体发信号的分子的方法。 | Hilla Knobler Ari Elson | 2014 | The Journal of Biomedical Research2014，28，3： | 2 |
| 3 | The second virial coefficients of the hydrogen iso- topes between 20 and 70 K显示文摘 | KNAAP H F P KNOESTER M KNOBLER C M | 1962 | Physica1962，28，1： | 1 |
| 4 | Multiple functional groups of varying ratios in metal-organic frameworks显示文摘 | Deng H Doonan C J Furukawa H Ferreira R B Towne J Knobler C B Wang B Yaghi O M | | 0，，： | 1 |
| 5 | Oral calcitriol (1,25-dihydroxyvitamin D3 ) does not augment UVB pho- totherapy for plaque psoriasis 显示文摘 | Prystowsky JH Knobler EH Muzio PJ | 1996 | J Am Acad Dermatol1996，35，21： | 1 |
| 6 | Increased risk of type 2 diabetes mellitus in non-cirrhotic patients with hepatitis C 显示文摘 | Knobler H Schihmanter R Zifroni A | 2000 | Mayo Clin Proc2000，75，4： | 1 |
| 7 | Fatty liver-an additional and treatable feature of the insulin resistance syndrome 显示文摘 | Knobler H Schattner A Zhomicki T | 1999 | QJM1999，92，2： | 1 |
| 8 | 显示文摘 | Fang J Y Knobler C M | 1996 | Langmuir1996，12，5： | 1 |
| 9 | The role of hyperglycemia in acute stroke 显示文摘 | Kagansky N Levy S Knobler H | 2001 | Arch Neurol2001，58，8： | 1 |
| 10 | Structures of self-assembled nonmetal borates derived from α,ω-diaminoalkanes显示文摘 | Visi M Z Knobler C B Owen J J | 2006 | Crystal Growth and Design2006，6，： | 1 |
| 11 | The role of hyperglycemia in acute stroke显示文摘 | Kagansky n Levy S Knobler H | 2001 | Arch Neurol2001，58，8： | 1 |
| 12 | Reduced glomerular filtration rate in asymptomatic diabetic patients predictor of increased risk for cardiac events independent of albuminuria显示文摘 | Knobler H Zornitzki T Vered S | 2004 | J Am Coll Cardiol2004，44，12： | 1 |
| 13 | Current management strategies for cutaneous T - cell lymphoma 显示文摘 | KNOBLER E | 2004 | Clin Dermatol2004，22，3： | 1 |
| 14 | Distribution of the blood-brain barrier in heterotopic brain transplants and its relationship to the lesions of EAE显示文摘 | Knobler RLl | 1992 | Neuropathol Exp Nerol1992，51，： | 1 |
| 15 | Protein tyrosine phosphatase epsilon affects body weight by downregulating leptin signaling in a phosphorylation-dependent manner 显示文摘 | Rousso-Noori L Knobler H Levy-Apter E | 2011 | Cell Metab2011，13，5： | 1 |
| 16 | Pressure/temperature phase diagrams and superlattices of organically functionalized metal nanocrystal monolayers: The influence of particle size, size distribution, and surface passivant 显示文摘 | Heath J R Knobler C M Leff D V 1997 | 1997 | J Phys Chem B1997，101，2： | 1 |
| 17 | Fatty liver--an additional and treatable feature of the insulin resistance syndrome显示文摘 | Schattner A Zhornicki T | 1999 | QJM1999，92，2： | 1 |
| 18 | Fatty liver an additional and treatable feature of the insulin resistance syndrome 显示文摘 | Knobler H Schattner A Zhornicki T etal | 1999 | QJMed1999，92，2： | 1 |
| 19 | EORTC consensus recommendations for the treatment of mycosis fungoides/Sezary syndrome显示文摘 | Trautinger F Knobler R Willemze R | 2006 | Eur J Cancer2006，42，8： | 1 |
| 20 | Shear-induced- platelet adhesion and aggregation on subendothelium are increased in diabetic patients 显示文摘 | Knobler H Savion N Shenkman B el al | 1998 | Thromb Res1998，90，4： | 1 |
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