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| 1 | Comparison of postpolypectomy bleeding between epinephrine and saline submucosal injection for large colon polyps by conventional polypectomy:A prospective randomized,multicenter study显示文摘AIM:To evaluate and compare the clinical outcomes of prophylactic submucosal saline-epinephrine injection and saline injection alone for large colon polyps by conventional polypectomy. METHODS:A prospective study was conducted from July 2003 to July 2004 at 11 tertiary endoscopic centers. Large colon polyps (> 10 mm in diameter) wererandomized to undergo endoscopic polypectomy with submucosal saline-epinephrine injection (epinephrine group) or normal saline injection (saline group). Endoscopic polypectomy was performed by the conventional snare method,and early (< 12 h) and late bleeding complications (12 h-30 d) were observed. RESULTS:A total of 561 polyps in 486 patients were resected by endoscopic polypectomy. Overall,bleeding complications occurred in 7.6% (37/486) of the patients,including 4.9% (12/244) in the epinephrine group,and 10.3% (25/242) in the saline group. Early and late postpolypectomy bleeding (PPB) occurred in 6.6% (32/486) and 1% (5/486) of the patients,respectively,including 4.5% (11/244),0.4% (1/244) in the epinephrine group,and 8.7% (21/242),1.7% (4/242) in the saline group. No significant differences in the rates of overall,early and late PPB were observed between the 2 groups. Multivariate stepwise logistic regression analysis revealed that large size (> 2 cm) and neoplastic polyps were independently and significantly associated with the presence of PPB. CONCLUSION:The prophylactic submucosal injection of diluted epinephrine does not appear to provide an additional advantage over the saline injection alone for the prevention of PPB. | Suck-Ho Lee Il-Kwun Chung Sun-Joo Kim Jin-Oh Kim Bong-Min Ko Won-Ho Kim Hyun-Soo Kim Dong-IL Park Hyo-Jong Kim Jeong-Sik Byeon Suk-Kyun Yang Byeong Ik Jang Sung-Ae Jung Yoon-Tae Jeen Jai-Hyun Choi Hwang Choi Dong-Soo Han Jae Suk Song | 2007 | World Journal of Gastroenterology2007，13，21： | 9 |
| 2 | 斯洛伐克西喀尔巴阡山脉内侧Veporicum地区的地球动力学演化序列与菱镁矿和滑石矿床成因(英文)显示文摘本文总结并报导了斯洛伐克西喀尔巴阡山脉内侧的石炭纪岩石中产出的菱镁矿和滑石成因的最新资料.这些矿床赋存于Veporicum构造超单元中和该超单元与Gemericum的接触带中.北部Sinec成矿带是主要的菱镁矿和滑石矿化区,产出的主要矿床有Kokava,Sinec,Samo,Hnsta-Mutnik等矿床.而南部的Ochtina成矿带只产有菱镁矿床,主要矿床包括在Dubrava地体上的Dubrava,Mikov?JedL'vec;Luben韐,Ochtina,Kosice-Bankov,Banisko,Medvedia等矿床.菱镁矿形成于变质M1期石炭系中方解石被白云石和菱镁矿连续交代过程(北矿带成矿温度为280~400℃,南矿带成矿温度为370~420℃;Radvanec&Prochska,2001;Kodera&Radvanec,2002).Permoscythian蒸发卤水提供了Mg.成矿事件和华力西期碰撞后运动有关.拉伸构造和高热流值促使成矿热液系统的产生.滑石矿化则形成于稍晚的不同期变质事件(M2),成矿流体来源也与菱镁矿化不同.构造的、微构造的、变质的以及地质年代学的数据将滑石成矿作用和阿尔卑斯上白垩系的构造地热事件AD2联系在一起.AD2事件是阿尔卑斯碰撞(AD1)地壳加厚和变质核杂岩体起源的结果,体现在地壳不整合面上的区域拉伸,及开放系统中大规模热液流动.这一过程在更靠近Veporic热穹的北带区域(Sinec剪切带)很显著,而向着Veporic热穹的周围部分(南Ochtina带),M2变质过程和块滑石化则逐渐减弱.Sinec剪切带是北Sinec带中突出的AD2-AD3结构,白云石/菱镁矿透镜体(在M1期交代造成的)和相伴随的岩石夹杂在AD1中更坚硬的基底岩石之中.本研究证明了AD2中块滑石化的普遍性,滑石和白云石2形成于拉伸显微构造中(变质过程M2;温度为490~540℃,压力为240~330MPa).在Sinec带中AD3阶段的对偶剪切作用形成了该带中的滑石矿.它是AD2事件从去顶到区域扭压剪切的动力学转变过程的逐步延续.北Sinec带使AD3变形处于由坚硬岩石包围的软岩石的狭窄的剪切带中,而在南Ochtina带中AD3变形产生在由里面漂浮着坚硬碳酸盐块的软的岩石柱中.在Ochtina带中,在AD2和AD3阶段由于M2期较低的P-T条件和变形梯度导致了该区有经济价值的滑石矿化不发育.总之,现有的研究结果能用作阿尔卑斯型地体中菱镁矿和滑石找矿的基本标志. | Zoltán NMETH Walter PROCHASKA Martin RADVANEC Martin KOV■IK Ján MADARAS Peter KOD■RA L'ubomír HRA■KO | 2004 | 岩石学报2004，20，4： | 2 |
| 3 | Outbreaks of imipenem-resistant Acinetobacter baumannii producing carbapenemases in Korea显示文摘 | Jeong SH Bae IK Park KO | 2006 | Clin Microbiol2006，44，4： | 1 |
| 4 | Amniotic fluid-derived stem cells in regenerative medicine research 显示文摘 | Joo S Ko IK Atala A | 2012 | Arch Pharm Res2012，35，： | 1 |
| 5 | Topiramate as an adjuvant treatment with atypical antipsychotics in schizophrenic patients experiencing weight gain 显示文摘 | Ko YH Joe SH Jung IK | 2005 | Clin Neuropharmacol2005，28，4： | 1 |
| 6 | In vivo MR imaging of tissue-engineered human mesenchymal stem cells transplanted to mouse: a preliminary study显示文摘 | Ko IK Song HT Cho EJ | 2007 | Ann Biomed Eng2007，35，1： | 1 |
| 7 | In vivo MR imaging of tissue-engi- neered human mesenchymal stem cells transplanted to mouse: a pre- liminary study显示文摘 | Ko IK Song HT Cho EJ | 2007 | Ann Biomed Eng2007，35，1： | 1 |
| 8 | Outbreaks of imipenem-resistant Aci- netobaeter baumannii producing carbapenemases in Korea 显示文摘 | Jeong SH Bae IK Park KO | 2006 | J Mi- crobiol2006，44，4： | 1 |
| 9 | Topiramate as an adjuvant treat- ment with atypical antipsychotics in schizophrenic patients experi- encing weight gain 显示文摘 | Ko YH Joe SH Jung IK | 2005 | Clin Neuropharmacol2005，28，4： | 1 |
| 10 | In vivo MR imaging of tissue-engineered human mesenehymal stem ceils transplanted to mouse: a preliminary study 显示文摘 | Ko IK Song HT Cho EJ | 2007 | Annal Biomed Engin2007，35，1： | 1 |
| 11 | Topiramate as an adjuvant neamaent with atypical fipsycbo- lies in schizophrenic patients experiencing weight gain 显示文摘 | Ko YH Joe SH Jtmg IK | | J Clin Neuropharmacol0，28，4： | 1 |
| 12 | Degradable polye -thylenimine-alt-poly (ethylene glycol) copolymers as novelgene carriers 显示文摘 | Park MR Han KO Han IK | 2005 | J Control Release2005，105，3： | 1 |
| 13 | Outbreaks of Imipenem-resist- ant Acinetobacter baumanniiin Producing VIM-1 Carbapenemase in Korea显示文摘 | Jeong SH Bae IK Park KO | 2006 | Clin Microbiology2006，44，4： | 1 |
| 14 | Bacteroides fragilis enterotoxin upregulates heme oxygenase-1 in dendritic cells via reactive oxygen species-,mitogen-activated protein kinase-,and Nrf2-dependent pathway显示文摘BACKGROUND Enterotoxigenic Bacteroides fragilis(ETBF)causes colitis and diarrhea,and is considered a candidate pathogen in inflammatory bowel diseases as well as colorectal cancers.These diseases are dependent on ETBF-secreted toxin(BFT).Dendritic cells(DCs)play an important role in directing the nature of adaptive immune responses to bacterial infection and heme oxygenase-1(HO-1)is involved in the regulation of DC function.AIM To investigate the role of BFT in HO-1 expression in DCs.METHODS Murine DCs were generated from specific pathogen-free C57BL/6 and Nrf2−/−knockout mice.DCs were exposed to BFT,after which HO-1 expression and the related signaling factor activation were measured by quantitative RT-PCR,EMSA,fluorescent microscopy,immunoblot,and ELISA.RESULTS HO-1 expression was upregulated in DCs stimulated with BFT.Although BFT activated transcription factors such as NF-κB,AP-1,and Nrf2,activation of NF-κB and AP-1 was not involved in the induction of HO-1 expression in BFT-exposed DCs.Instead,upregulation of HO-1 expression was dependent on Nrf2 activation in DCs.Moreover,HO-1 expression via Nrf2 in DCs was regulated by mitogenactivated protein kinases such as ERK and p38.Furthermore,BFT enhanced the production of reactive oxygen species(ROS)and inhibition of ROS production resulted in a significant decrease of phospho-ERK,phospho-p38,Nrf2,and HO-1 CONCLUSION These results suggest that signaling pathways involving ROS-mediated ERK and p38 mitogen-activated protein kinases-Nrf2 activation in DCs are required for HO-1 induction during exposure to ETBF-produced BFT. | Su Hyuk Ko Jong Ik Jeon Hyun Ae Woo Jung Mogg Kim | 2020 | World Journal of Gastroenterology2020，26，3： | 1 |
| 15 | Combined systemic and local delivery of stem cell inducing/recruiting factors for in situ tissue regeneration显示文摘 | Ko IK Ju YM Chen T | | 0，，01： | 1 |
| 16 | High transfection efficiency of poly ( 4-vinylimidazole ) as a new gene carrier 显示文摘 | Ihm JE Han KO Han IK | 2003 | Bioconjug Chem2003，14，4： | 1 |
| 17 | Outbreaks of imipenem resistant Acinetobacter baumannii producing carbapenemases in Korea 显示文摘 | Jeong SH Bae IK Park KO | 2006 | J Microbiol2006，44，4： | 1 |
| 18 | Outbreaks of Imipenem-Resist-ant Acinetobacter baumannii Producing Carbapenemases in Korea显示文摘 | Jeong SH Bae IK Park KO | 2006 | J Microbiol2006，44，4： | 1 |
| 19 | In vivo MR imaging of tissue- engineered human mesenchymal stem cells transplanted to m- ouse: a preliminary study显示文摘 | Ko IK Song HT Cho EJ | 2007 | Ann Biomed Eng2007，35，1： | 1 |
| 20 | Outbreaks of imipenem resistant Acinetobacter baumannii producing carbapenemases in Korea 显示文摘 | Jeong SH Bae IK Park KO | 2006 | J Microbial2006，44，4： | 1 |
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