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| 1 | Current concepts in the immunohistochemical evaluation of liver tumors显示文摘Immunohistochemistry often plays an important role in the evaluation of liver tumors. Recent advances have established a classification system for hepatocellular adenomas(HCAs) based on morphology,molecular alterations,and immunohistochemistry. Specifically,loss of liver fatty acid binding protein is seen in HNF1α-inactivated HCA,staining with serum amyloid A isseen in inflammatory HCA,and diffuse staining with glutamine synthetase(GS) is seen in β-catenin activated HCA. A panel of immunohistochemical stains including glypican-3(GPC-3),heat shock protein 70,and GS are useful in distinguishing HCC from non-malignant dysplastic nodules. Immunohistochemistry is also useful to determine whether a liver tumor is of primary hepatocellular or metastatic origin. Recently described markers useful for this purpose include arginase-1,GPC-3,and bile salt export pump. These newer markers may offer superior utility when compared to traditional markers of hepatocellular differentiation such as alpha-fetoprotein,hepatocyte paraffin-1,polyclonal carcinoembryonic antigen,and CD10. This paper will review recent advances in the immunohistochemical evaluation of liver tumors. | Anne K Koehne de Gonzalez Marcela A Salomao Stephen M Lagana | 2015 | World Journal of Hepatology2015，7，10： | 6 |
| 2 | Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF–RANKL signaling显示文摘Skeletal health relies on architectural integrity and sufficient bone mass, which are maintained through a tightly regulated equilibrium of bone resorption by osteoclasts and bone formation by osteoblasts. Genetic studies have linked the gene coding for low-density lipoprotein receptor-related protein1(Lrp1) to bone traits but whether these associations are based on a causal molecular relationship is unknown. Here, we show that Lrp1 in osteoblasts is a novel regulator of osteoclast activity and bone mass.Mice lacking Lrp1 specifically in the osteoblast lineage displayed normal osteoblast function but severe osteoporosis due to highly increased osteoclast numbers and bone resorption. Osteoblast Lrp1 limited receptor activator of NF-κB ligand(RANKL) expression in vivo and in vitro through attenuation of platelet-derived growth factor(PDGF-BB) signaling. In co-culture, Lrp1-deficient osteoblasts stimulated osteoclastogenesis in a PDGFRβ-dependent manner and in vivo treatment with the PDGFR tyrosine kinase inhibitor imatinib mesylate limited RANKL production and led to complete remission of the osteoporotic phenotype. These results identify osteoblast Lrp1 as a key regulator of osteoblast-to-osteoclast communication and bone mass through a PDGF–RANKL signaling axis in osteoblasts and open perspectives to further explore the potential of PDGF signaling inhibitors in counteracting bone loss as well as to evaluate the importance of functional LRP1 gene variants in the control of bone mass in humans. | Alexander Bartelt Friederike Behler-Janbeck F.Timo Beil Till Koehne Brigitte Müller Tobias Schmidt Markus Heine Laura Ochs Tayfun Yilmaz Martin Dietrich Jan P.Tuckermann Michael Amling Joachim Herz Thorsten Schinke Joerg Heeren Andreas Niemeier | 2018 | Bone Research2018，6，1： | 5 |
| 3 | ABC efflux transporters at blood-central nervous system barriers and their implications for treating spinal cord disorders显示文摘The barriers present in the interfaces between the blood and the central nervous system form a major hurdle for the pharmacological treatment of central nervous system injuries and diseases.The family of ATP-binding cassette(ABC)transporters has been widely studied regarding efflux of medications at blood-central nervous system barriers.These efflux transporters include P-glycoprotein(abcb1),‘breast cancer resistance protein'(abcg2)and the various‘multidrug resistance-associated proteins'(abccs).Understanding which efflux transporters are present at the blood-spinal cord,blood-cerebrospinal fluid and cerebrospinal fluid-spinal cord barriers is necessary to determine their involvement in limiting drug transfer from blood to the spinal cord tissue.Recent developments in the blood-brain barrier field have shown that barrier systems are dynamic and the profile of barrier defenses can alter due to conditions such as age,disease and environmental challenge.This means that a true understanding of ABC efflux transporter expression and localization should not be one static value but instead a range that represents the complex patient subpopulations that exist.In the present review,the blood-central nervous system barrier literature is discussed with a focus on the impact of ABC efflux transporters on:(i)protecting the spinal cord from adverse effects of systemically directed drugs,and(ii)limiting centrally directed drugs from accessing their active sites within the spinal cord. | Liam M. Koehn | 2020 | Neural Regeneration Research2020，15，7： | 3 |
| 4 | Vascular endothelial growth factor and erythropoietin concentrations in cerebrospinal fluid of children with hydrocephalus 显示文摘 | Koehne P Hochhaus F Felderhoff-Mueser U | 2002 | Childs Nerv Syst2002，18，： | 2 |
| 5 | Inconsistent effects of acidosis on HIF-alpha protein and its target genes显示文摘 | Willam C Warnecke C Sehefold J C Kugler J Koehne P Frei U | 2006 | Pflugers Arch2006，451，： | 1 |
| 6 | Phenotype of lymphocyte subsets after autologous peripheral blood stem cell transplantation显示文摘 | Koehne G Zeller W Stockschlaeder M | 1997 | Bone Marrow Transplant1997，19，2： | 1 |
| 7 | Initial effects of low-level laser therapy on growth and differentiation of human osteoblast-like cells显示文摘 | Stein E Koehn J Sutter W | 2008 | Wien Klin Wochenschr2008，120，34： | 1 |
| 8 | Loss of recep- tor 2 mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice 显示文摘 | Moore KJ KunjathoorVV Koehn SL | 2005 | J Clin Invest2005，115，8： | 1 |
| 9 | Reliability and validity testing of three breastfeeding assessment tools显示文摘 | Riordan J M Koehn M | 1997 | J Obstet Gynecol Neonatal Nurs1997，26，2： | 1 |
| 10 | The TD-CDMA Based UTRA TDD Mode 显示文摘 | HAARDT M KLEIN A KOEHN R | 2000 | IEEE Journal on Selected Areas in Communications2000，18，8： | 1 |
| 11 | The adaptive importance of genetic variation显示文摘 | Koehn R K Hilbish T J | 1987 | Am Sci1987，75，： | 1 |
| 12 | Regulation of Bank Capital and Portfolio Risk显示文摘 | Koehn | 1980 | Journal of Finance1980，，35： | 1 |
| 13 | Medical education for a changing world:mov- ing beyond cultural competence into transnational competence 显示文摘 | Koehn PH Swick HM | 2006 | Acad Med2006，，81： | 1 |
| 14 | Statistical phrase -basedtranslation显示文摘 | Koehn P Och F J Marcu D | 2003 | Association for Computational Linguistics2003，4854，： | 1 |
| 15 | Patient Education and Self-man- agement of Musculoskeletal Diseases显示文摘 | Koehn C L Esdaile J M | 2008 | Best Pract Res Clin Rheumatol2008，22，3： | 1 |
| 16 | Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atheroseleresis in hyperlipidemic mice 显示文摘 | Moore K J Kunjathoor VV Koehn SL | 2005 | J Clin Invest2005，115，8： | 1 |
| 17 | Assessing the function of human UNC-93B in Toll-like receptor signaling and major histocompatibility complex II response 显示文摘 | Koehn J Huesken D Jaritz M | 2007 | Human lmmuno2007，68，11： | 1 |
| 18 | Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice显示文摘 | Moore K J Kunjathoor VV Koehn SL | 2005 | J Clin Invest2005，115，8： | 1 |
| 19 | Pyridoacridine alkaloids from deep-water marine spOnges of the family Pachastrellidae: structure revision of dercitin and related compounds and correlation with the kuanoniamines显示文摘 | Gunawardana GP Koehn FE Lee AY | 1992 | J OrgChem1992，57，： | 1 |
| 20 | Platelet-rich plasma for the treatment of patent duetus arteriosus : not quite ready for prime time显示文摘 | Salhnon H Barikbin P Koehne P | 2014 | Cardiol Young2014，27，4： | 1 |
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