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| 1 | Non-small bowel lesion detection at small bowel capsule endoscopy: A comprehensive literature review显示文摘Small bowel capsule endoscopy is a minimally-invasive endoscopic investigation that is often used in clinical practice to investigate overt or occult gastrointestinal(GI) bleeding among other clinical indications. International guidance recommends small bowel capsule endoscopy as a first-line investigation to detect abnormalities in the small bowel, when gastroscopy and colonoscopy fail to identify a cause of GI bleeding. It can diagnose with accuracy abnormalities in the small bowel. However, there has been increasing evidence indicating that small bowel capsule endoscopy may also detect lesions outside the small intestine that are within the reach of conventional endoscopy and have been probably missed during prior endoscopic investigations. Such lesions vary from vascular deformities to malignancy and their detection often alters patient management, leading to further endoscopic and/or surgical interventions. The current study attempts to review all available studies in the literature and summarise their relevant findings. | Apostolos Koffas Faidon-Marios Laskaratos Owen Epstein | 2018 | World Journal of Clinical Cases2018，6，15： | 2 |
| 2 | Role of autophagy in gastric carcinogenesis显示文摘Gastric cancer represents a common and highly fatal malignancy,and thus a pathophysiology-based reconsideration is necessary,given the absence of efficient therapeutic regimens.In this regard,emerging data reveal a significant role of autophagy in gastric oncogenesis,progression,metastasis and chemoresistance.Although autophagy comprises a normal primordial process,ensuring cellular homeostasis under energy depletion and stress conditions,alterations at any stage of the complex regulatory system could stimulate a tumorigenic and promoting cascade.Among others,Helicobacter pylori infection induces a variety of signaling molecules modifying autophagy,during acute infection or after chronic autophagy degeneration.Subsequently,defective autophagy allows malignant transformation and upon cancer establishment,an overactive autophagy is stimulated.This overexpressed autophagy provides energy supplies and resistance mechanisms to gastric cancer cells against hosts defenses and anticancer treatment.This review interprets the implicated autophagic pathways in normal cells and in gastric cancer to illuminate the potential preventive,therapeutic and prognostic benefits of understanding and intervening autophagy. | Apostolis Papaefthymiou Gregory Christodoulidis Apostolos Koffas Michael Doulberis Stergios A Polyzos Anastasios Manolakis Spyros Potamianos Andreas Kapsoritakis Jannis Kountouras | 2021 | World Journal of Gastrointestinal Oncology2021，13，10： | 2 |
| 3 | Training in video capsule endoscopy: Current status and unmet needs显示文摘Since its introduction to clinical practice nearly 20 years ago, wireless capsule endoscopy has revolutionized the landscape in the diagnosis and management of small bowel diseases. Over the past 10 years, capsule endoscopy has evolved beyond the small intestine and a range of capsules are now available to examine the esophagus, stomach and colon. Because of its ease of use, tolerability, paucity of complications and ability to visualize the entire gastrointestinal tract, capsule endoscopy has entered the mainstream of clinical practice. This review of the literature summarizes the current state of capsule training and highlights the limited data available to assess reader competence and standards expected of an independent practitioner. There are neither standardized teaching strategies nor national or international metrics for accreditation of physicians and nonphysicians interested in mastering this examination. Summating the few publications, there appears to be consensus that diagnostic expertise improves with experience, and that trainees should be fully supervised for at least 20 full case studies. Formative and summative assessment is advisable and the number of taught cases should not be the sole determinant of competence. The review also highlights differences in recommendations from major national gastroenterology societies. Finally, the authors discuss areas of unmet needs in teaching and learning for capsule endoscopy. | Apostolos Koffas Faidon-Marios Laskaratos Owen Epstein | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，6： | 2 |
| 4 | Cerebellar hemorrhage and cerebellar infarct:Retrospective study of 125 cases显示文摘 | Wien M Landers R J Koffa M | 1993 | Wochenschr1993，143，6： | 1 |
| 5 | Optimi- zation of a heterologous pathway for the production of fla- vonoids from glucose 显示文摘 | Santos C N Koffas M A G Stephanopoulos G | 2011 | Metabolic Engineering2011，13，4： | 1 |
| 6 | Biosynthesis of isoprenoids, polyunsaturated fatty acids and flavonoids in Saccharomyces cerevisiae 显示文摘 | Chemler J A Yan Yajun Koffas M A G | 2006 | Microbial Cell Facto- ries2006，，5： | 1 |
| 7 | Detection of herpes simplex virus (HSV) in aborted material using the polymerase chain reaction technique显示文摘 | Sifakis S Koumantakis E Koffa M | 1998 | Gynecol-obstet-invest1998，45，2： | 1 |
| 8 | Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the hu- man cell cycle显示文摘 | KoffA Giordano A Desai D | 1992 | Science1992，257，5077： | 1 |
| 9 | Increased malonyl coenzyme A biosynthesis by tuning the Esche- richia coli metabolic network and its application to flava- none production显示文摘 | Fowler Z L Gikandi W W Koffas M A G | 2009 | Applied and Environmental Micro- biology2009，75，18： | 1 |
| 10 | Human cyclin E, a new eyclin that interacts with two members of the CDC2 gene family 显示文摘 | KoffA Cross F Fisher A | 1991 | Cell1991，66，6： | 1 |
| 11 | Biosynthesis of isoprenoids, polyunsaturated fatty acids and flavonoids in Saccharomyces cerevisiae 显示文摘 | JA Chemler Y Yan MAG Koffas | 2006 | Microbial Cell Factories2006，20，5： | 1 |
| 12 | Biosynthesis of natural fiavanones in Saccharomyces cerevisiae 显示文摘 | Yan Yajun Kohli A Koffas M A G | 2005 | Ap- plied and Environmental Microbiology2005，71，9： | 1 |
| 13 | Cerebellar haemorrhage and cerebellar infarct:retrospective study of 125 cases显示文摘 | Landers RJ Koffa M | 1993 | Wochenschr1993，143，6： | 1 |
| 14 | Engineering plant metabolism into microbes: from systems biology to syn- thetic biology 显示文摘 | Xu Peng Bhan N Koffas M A G | 2013 | Current Opinion in Biotechnology2013，24，2： | 1 |
| 15 | Biosynthesis and biotechnologi- cal production of flavanones: Current state and perspectives显示文摘 | Fowler Z L Koffas M A G | 2009 | Applied Microbiology and Biotechnology2009，83，5： | 1 |
| 16 | flavonoid hydroxylase for the Functional expression of a P450 biosynthesis of plant-specific hydroxylated flavonols in Escherichia coli显示文摘 | Leonard E Yan Y Koffas MA | 2006 | Metab Eng2006，8，2： | 1 |
| 17 | Cerebellar hemorrhage and cerebellar infarct: retrospective study of 125 cases显示文摘 | Wien M Landers RJ Koffa M | 1993 | Wochenschr1993，143，6： | 1 |
| 18 | Biosynthesis of isoprenoids, polyunsaturated fatty acids and flavonoids in Saccharomyces cerevisiae显示文摘 | Chemler J Yan Y Koffas M | 2006 | Microbial Cell Factories2006，5，1： | 1 |
| 19 | Genome-scale metabolic network modeling results in minimal interventions that cooperatively force carbon flux towards malonyl-CoA显示文摘 | Peng Xu Sridhar Ranganathan Zachary L. Fowler Costas D. Maranas Mattheos A.G. Koffas | 2011 | Metabolic Engineering2011，，5： | 1 |
| 20 | Formation and activation of a cyclin E-cdk2 complex during the GL phase of the human cell cycle 显示文摘 | KoffA Gordano A Desai D | 1992 | Science1992，257，5077： | 1 |
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