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| 1 | Current medical management of endocrine-related male infertility显示文摘男因素贡献全面不孕的 50%-60% ,但是是完全负责的在仅仅 20% 夫妇。尽管很男的因素不孕从反常精液分析被查明,如果样品归还正常,另外的男因素能特别是贡献的。男不孕能由于可能可逆或不可逆的可看作是相同的神经质或解剖的病原学。这张手稿将包括多种维生素,雌激素受体调节的人(clomiphene ) ,雌激素变换 blockers (anastrozole ) ,和荷尔蒙代替为男不孕和实验治疗为荷尔蒙评估加亮存在指南和我们的建议。 | Joshua D Ring Aye A Lwin Tobias S Kohler | 2016 | Asian Journal of Andrology2016，18，3： | 12 |
| 2 | Arabidopsis SWC4 Binds DNA and Recruits the SWR1 Complex to Modulate Histone H2A.Z Deposition at Key Regulatory Genes显示文摘由在特定的 loci 的规章的区域的 SWR1 建筑群(SWR1-C ) 的 H2A.Z histone 变体的免职调制抄写。在 Arabidopsis thaliana 的变化的描述 ? 酵母 SWR1-C 的相当或相同的事物在许多发展过程为 H2A.Z 交换揭示了一个角色。不过,植物 SWR1-C 的准确作文并且指向基因怎么被招募,尚待被证实。这里,我们显示出那 SWC4,酵母 SANT 领域蛋白质 Swc4/Eaf2 的 Arabidopsis 相当或相同的事物,是与 SWR1-C 子单元交往的 DNA 有约束力的蛋白质。当 SWC4 RNAi 击倒的线显示时,我们证明 swc4-1 大美人异种是胚胎致命的 ? 包括 flowering 时间的加速,显示 SWC4 控制 embryonic 以后处理的植物、繁殖的特点地的多种的 phenotypic 改变。Transcriptomic 分析并且 H2A.Z 的染色体宽的介绍显示 SWC4 镇压很多基因的抄写包括花的综合者英尺和关键抄写因素,主要由 modulating H2A.Z 免职。有趣地, SWC4 silencing 不在 FLC 地点也不这基因的表示影响 H2A.Z 免职,以前显示出被 SWR1-C 控制的 flowering 的一个主人管理者。重要地,我们发现 SWC4 在目标基因的染色质区域认出特定的在富有的 DNA 元素并且 SWC4 silencing 一起损害在英尺有约束力的 SWR1-C,我们的数据建议 SWC4 由帮助 SWR1-C 招募和 modulating H2A.Z 调整植物生长和开发免职。 | Angeles Gomez-Zambrano Pedro Crevillen Jose M. Franco-Zorrilla Juan A. Lopez Jordi Moreno-Romero Pawel Roszak Juan Santos-Gonzalez Silvia Jurado Jesus Vazquez Claudia Kohler Roberto Solano Manuel Pineiro Jose A. Jarillo | 2018 | Molecular Plant2018，11，6： | 11 |
| 3 | Control of PHERES1 Imprinting in Arabidopsis by Direct Tandem Repeats显示文摘印的 Genomic 是引起依赖于 parent-of-origin 的特定的基因的 monoallelic 表示的 epigenetic 现象。Arabidopsis 基因 PHERES1 印要求 FERTILIZATION 独立种子(FIS ) Polycomb 组建筑群以及包含一个双人脚踏车三元组重复序列的一个远侧地定位的 methylated 区域的功能。在这研究,我们调查了靠近的 PHERES1 相当或相同的事物 PHERES2 的规定。我们发现 PHERES2 也是 FIS Polycomb 组建筑群的直接目标基因,,但是,与 PHERES1 相对照, PHERES2 同等地从母亲、父亲的等位基因被表示。因此, PHERES2 没被印的 genomic 调整,与在 PHERES2 的双人脚踏车重复的缺乏相关。从 PHERES1 地点消除双人脚踏车重复废除印的 PHERES1,证明双人脚踏车重复为印的 PHERES1 是必要的。一起拿这些结果,我们最近复制的基因 PHERES1 和 PHERES2 两个都是 FIS Polycomb 的目标基因的学习表演组织建筑群但是仅仅 PHERES1 被印的 genomic 调整,它是可能的在 PHERES1 地点的最近由重复序列的存在引起了。 | Corina Belle R. Villar Aleksandra Erilova Grigory Makarevich Raphael Trosch Claudia Kohler | 2009 | Molecular Plant2009，2，4： | 6 |
| 4 | Analysis of the genetic interactions between Cyclin A1, Atm and p53 during spermatogenesis显示文摘瞄准:在精子发生和 DNA 双海滨裂缝修理与 p53 和 Atm 分析 Cyclin 的功能的相互作用。方法:两倍猛烈老鼠的二根线被产生。精子发生和两倍海滨裂缝修理机制在 Cyclin A1 (Ccnal ) 被分析;p53- 和 Ccnal;Atm -- 两倍猛烈老鼠。结果:在在 mid-diplotene 阶段在 Cyclin A1-/-(Ccnal-/-) 睾丸观察的精子发生的块与 polynucleated 巨人房间被联系。我们发现 Ccnal 缺乏的睾丸和特别巨大的房间积累 DNA 双海滨打破,为 phosphorylated H2AX 由免疫组织化学检测了的 unrepaired。另外,巨大的房间逃离 apoptosis。因为睾丸缺乏 ATM,它为 develop 精子发生的所知比前期Ⅰ早逮捕,巨大的房间的发展发生在 meiotic 前期Ⅰ,别当 cyclin A1 不在时开发巨大的房间。Cyclin A1 与 CDK2 在建筑群与 p53 和 phosphorylated p53 交往了。有趣地, p53 缺乏显著地在 Ccnal 缺乏的睾丸增加了巨大的房间的数字。在变异的睾丸的 DNA 修理基因的一块面板的基因表达式分析表明任何一个都一致地没当 cyclin A1 不在时检验的基因被调整。结论:在精子发生的 Ccnal 缺乏在 DNA 双海滨裂缝修理与缺点被联系,它被 p53 的损失提高。 | Nicole Baiumer Marie-Luise Sandstede Sven Diederichs Gabriele Kohler Carol Readhead Ping Ji Feng Zhang Etmar Bulk Jorg Gromoll Wolfgang E. Berdel Hubert Serve Carsten Muller-Tidow | 2007 | Asian Journal of Andrology2007，9，6： | 4 |
| 5 | Interventional treatment of the left subclavian in 2 patients with coronary steal syndrome显示文摘In patients with history of coronary artery disease angina pectoris is usually attributed to the progression of atherosclerotic lesions. However,in patients with previous coronary artery bypass graft operation(CABG) using internal mammary artery grafts,great vessel disease should also be considered. Herein we present two patients with history of CABG whose symptoms were suspicious for coronary ischemia. During cardiac catheterization reverse blood flow was observed from the left artery disease to the left internal mammary artery(LIMA) graft in both cases. After angioplasty and stent implantation of the left subclavian artery antegrade flow was restored in the LIMA grafts and both patients had complete resolution of symptoms. | Julia Heid Britta Vogel Arnt Kristen Wanda Kloos Benedikt Kohler Hugo A Katus Grigorios Korosoglou | 2017 | World Journal of Cardiology2017，9，1： | 3 |
| 6 | Taking out the garbage:cathepsin D and calcineurin in neurodegeneration显示文摘Cellular homeostasis requires a tightly controlled balance between protein synthesis, folding and degradation. Especially long-lived, post-mitotic cells such as neurons depend on an efficient proteostasis system to maintain cellular health over decades. Thus, a functional decline of processes contributing to protein degradation such as autophagy and general lysosomal proteolytic capacity is connected to several age-associated neurodegenerative disorders, including Parkinson's, Alzheimer's and Huntington's diseases. These so called proteinopathies are characterized by the accumulation and misfolding of distinct proteins, subsequently driving cellular demise. We recently linked efficient lysosomal protein breakdown via the protease cathepsin D to the Ca^(2+)/calmodulin-dependent phosphatase calcineurin. In a yeast model for Parkinson's disease, functional calcineurin was required for proper trafficking of cathepsin D to the lysosome and for recycling of its endosomal sorting receptor to allow further rounds of shuttling. Here, we discuss these findings in relation to present knowledge about the involvement of cathepsin D in proteinopathies in general and a possible connection between this protease, calcineurin signalling and endosomal sorting in particular. As dysregulation of Ca^(2+) homeostasis as well as lysosomal impairment is connected to a plethora of neurodegenerative disorders, this novel interplay might very well impact pathologies beyond Parkinson's disease. | Andreas Aufschnaiter Verena Kohler Sabrina Büttner | 2017 | Neural Regeneration Research2017，12，11： | 3 |
| 7 | 精明增长与绿色基础设施如何相互支持:紧凑绿色城市的概念框架显示文摘紧凑型城市被规划师和研究者认为是更可持续发展的城市形态。然而,紧凑城市的局限性之一在于绿地率较低,而这将危害城市生态系统服务的充足供应。本文试图整合以紧凑型城市形态为特征的精明增长以及以多尺度绿色空间网络为特征的绿色基础设施,从而系统性地提出紧凑绿色城市(compact and green cities)的概念框架。 | ARTMANN M KOHLER M MEINEL G | 2018 | 城市规划学刊2018，，1： | 3 |
| 8 | 汽车制造商拥抱48V轻混系统显示文摘全球的汽车制造商已经开始推出采用新48V电源子系统的汽车。本文就48V电源子系统相关性能及系统优势进行了详细介绍,同时介绍了一款12V/48V电源系统及双向DC/DC同步PWM控制器ISL78226。 | Ed Kohler | 2017 | 电子产品世界2017，24，9： | 2 |
| 9 | 血压变异性加大与认知功能减退相关显示文摘由于预期寿命增加,越来越多的人将面临与增龄相关的认知困难。因此,确定认知障碍的可改变的风险因素非常重要。极短期到中期的血压变异性(blood pressure variability,BPV)可能就是这样一个因素,因为它可能导致脑缺血。 | Zhou TL Kroon AA van Sloten TT van Boxtel MPJ Verhey FRJ Schram MT Kohler S Stehouwer CDA Henry RMA 刘莉(译) 叶鹏(摘、审校) | 2019 | 中华高血压杂志2019，0，3： | 2 |
| 10 | The click modular router显示文摘 | Eddie Kohler Robert Morris Benjie Chen John Jannotti M. Frans Kaashoek | 2000 | ACM Transactions on Computer Systems (TOCS)2000，，3： | 2 |
| 11 | 有机半导体中与电子有关的过程概论显示文摘有机半导体是具有半导体性质的有机材料,其导电能力介于金属和绝缘体之间。有机半导体与传统半导体的区别是:有机半导体由有机分子构成,电学性能主要是由激发态的空穴和电子决定的。如今,有机半导体应用于许多领域,比如有机发光二极管(OLED)、手机显示屏、发光材料、光电材料等。有机半导体潜在的光电物理性能研究以及光电器件技术研究已经到了成熟的地步。 | Anna Kohler 彭金平 | 2015 | 国外科技新书评介2015，0，12： | 2 |
| 12 | Sovlent Effects on the Fluorescence Properties of Anilines显示文摘 | Kohler G J | 1987 | J Photochem1987，38，： | 2 |
| 13 | Biophotonic sensors with integrated Si_(3)N_(4)-organic hybrid (SiNOH) lasers for point-of-care diagnostics显示文摘Early and efficient disease diagnosis with low-cost point-of-care devices is gaining importance for personalized medicine and public health protection.Within this context,waveguide-(WG)-based optical biosensors on the siliconnitride(Si_(3)N_(4))platform represent a particularly promising option,offering highly sensitive detection of indicative biomarkers in multiplexed sensor arrays operated by light in the visible-wavelength range.However,while passive Si_(3)N_(4)-based photonic circuits lend themselves to highly scalable mass production,the integration of low-cost light sources remains a challenge.In this paper,we demonstrate optical biosensors that combine Si_(3)N_(4)sensor circuits with hybrid on-chip organic lasers.These Si_(3)N_(4)-organic hybrid(SiNOH)lasers rely on a dye-doped cladding material that are deposited on top of a passive WG and that are optically pumped by an external light source.Fabrication of the devices is simple:The underlying Si_(3)N_(4)WGs are structured in a single lithography step,and the organic gain medium is subsequently applied by dispensing,spin-coating,or ink-jet printing processes.A highly parallel read-out of the optical sensor signals is accomplished with a simple camera.In our proof-of-concept experiment,we demonstrate the viability of the approach by detecting different concentrations of fibrinogen in phosphate-buffered saline solutions with a sensor-length(L-)-related sensitivity of S/L=0.16 rad nM^(-1)mm^(-1).To our knowledge,this is the first demonstration of an integrated optical circuit driven by a co-integrated low-cost organic light source.We expect that the versatility of the device concept,the simple operation principle,and the compatibility with cost-efficient mass production will make the concept a highly attractive option for applications in biophotonics and point-of-care diagnostics. | Daria Kohler Gregor Schindler Lothar Hahn Johannes Milvich Andreas Hofmann Kerstin Lange Wolfgang Freude Christian Koos | 2021 | Light(Science & Applications)2021，10，4： | 2 |
| 14 | 先天性巨结肠合并结肠失弛缓症 | Kohler S. Fitze G. Hosie S. S.Holland-Cunz 肖莉 | 2005 | 世界核心医学期刊文摘(儿科学分册)2005，0，7： | 2 |
| 15 | The click modular router显示文摘 | Eddie Kohler Robert Morris Benjie Chen John Jannotti M. Frans Kaashoek | 2000 | ACM Transactions on Computer Systems (TOCS)2000，，： | 2 |
| 16 | Continuous cultures of fused cells secreting antibody of predefined specificity显示文摘 | Kohler G Milstein C | 1975 | Nature1975，256，7： | 2 |
| 17 | 未来汽油机方案及其燃料显示文摘“汽油机如同柴油机一样节油”是未来所有新型汽油机方案的主题。为此,汽油机要进行许多技术优化,现在的开发任务是要寻找正确的组合方案,以满足燃油耗、功率、排放,尤其是成本等方面的所有要求。 | Kohler H | 2007 | 国外内燃机2007，39，5： | 2 |
| 18 | Rotavirus as a cause of diarrhea in pigs 显示文摘 | Bohl E H Kohler E M Saif L J | 1978 | J Am Vet Med Assoc1978，172，： | 1 |
| 19 | Rice Bran Protein Concentrates by Wet Alkaline Extraction显示文摘 | Conner M Saunders R M Kohler G O | 1973 | Cereal Chemistry1973，，53： | 1 |
| 20 | Laparoscopic-assisted radical vaginal hystercctomy (LARVH):prospective evaluation of 200 patients with cervical cancer显示文摘 | Kohler C Michels W | 2003 | Gynecol Oncol2003，90，3： | 1 |
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