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| 1 | Inflammation-associated microsatellite alterations:Mechanisms and significance in the prognosis of patients with colorectal cancer显示文摘Microsatellite alterations within genomic DNA frameshift as a result of defective DNA mismatch repair(MMR). About 15% of sporadic colorectal cancers(CRCs) manifest hypermethylation of the DNA MMR gene MLH1, resulting in mono-and di-nucleotide frameshifts to classify it as microsatellite instability-high(MSI-H) and hypermutated, and due to frameshifts at coding microsatellites generating neo-antigens, produce a robust protective immune response that can be enhanced with immune checkpoint blockade. More commonly, approximately 50% of sporadic nonMSI-H CRCs demonstrate frameshifts at di-and tetra-nucleotide microsatellites to classify it as MSIlow/elevated microsatellite alterations at selected tetranucleotide repeats(EMAST) as a result of functional somatic inactivation of the DNA MMR protein MSH3 via a nuclear-to-cytosolic displacement. The trigger for MSH3 displacement appears to be inflammation and/or oxidative stress, and unlike MSI-H CRC patients, patients with MSI-L/EMAST CRCs show poor prognosis. These inflammatory-associated microsatellite alterations are a consequence of the local tumor microenvironment, and in theory, if the microenvironment is manipulated to lower inflammation, the microsatellite alterations and MSH3 dysfunction should be corrected. Here we describe the mechanisms and significance of inflammatory-associated microsatellite alterations, and propose three areas to deeply explore the consequences and prevention of inflammation's effect upon the DNA MMR system. | Minoru Koi Stephanie S Tseng-Rogenski John M Carethers | 2018 | World Journal of Gastrointestinal Oncology2018，10，1： | 7 |
| 2 | Probing of the spliceoseme with site-specifically derivatized 5' splice site RNA oligonucleotides显示文摘 | LEVY T KOIS P | 1998 | RNA1998，4，： | 1 |
| 3 | Expression of SHOOT MER1STEMLESS, WUSCHEL, and ASYMMETRIC LEAVES1 homologs in the shoots of Podostemaceae: Implications for the evolution of novel shoot organogenesis显示文摘 | Katayama N Koi S Kato M | 2010 | The Plant Cell2010，22，7： | 1 |
| 4 | The biochemical basis ol microsatellite instability and abnormal immunohisto- chemistry and clinical behavior in Lynch syndrome:lrom bench to bedside 显示文摘 | Boland C Koi M Chang D | 2008 | Fam Cancer2008，7，1： | 1 |
| 5 | Mutations in both KRAS and BRAF may contribute to the methylator phenotype in colon cancer显示文摘 | Nagasaka T Koi M Kloor M | 2008 | Gastroenterology2008，134，7： | 1 |
| 6 | Placental extravillous cytotrophoblasts persistently express class I major histocompatibility complex molecules after human cytomegalovirus infection显示文摘 | Terauchi M Koi H Hayano C | 2003 | J Virol2003，77，15： | 1 |
| 7 | The biochemical basis of mic- rosatellite instability and abnormal immunohistochemistry and clinical behavior in Lynch syndrome:from bench to bedside 显示文摘 | Boland C Koi M chang D | 2008 | Fam Cancer2008，7，1： | 1 |
| 8 | Singapore's lntemet shoppers and their impact on traditional shopping patterns 显示文摘 | Sim L L Koi S M | 2002 | Journal of Retailing and Consumer Services2002，9，2： | 1 |
| 9 | Singapore' s intemet shoppers and their im- pact on traditional shopping patterns 显示文摘 | Sim L L Koi S M | 2002 | Journal of Retailing and Consumer Services2002，9，2： | 1 |
| 10 | Electrodeposition of Gu-In-Ga thin metal films for Cu (In, Ga)Se2 based solar cells显示文摘 | Ganchev Kois M Kaelin M | 2008 | Thin Solid Films2008，516，18： | 1 |
| 11 | Role of connective tissue growth factor in profibrotic action of transforming growth factor-beta: a potential target for preventing renal fibrosis显示文摘 | Yo koi H Sugawara A Mukoyama M | 2001 | Am J Kidney Dis2001，38，41： | 1 |
| 12 | Both episomal and integrated forms of human papillomavirus type 16 are invovled in invasive cervical cancers显示文摘 | Matsukura T Koi S Sugase M | 1989 | Virology1989，172，1： | 1 |
| 13 | Issue of pros- tate gland size, laparoscopic radical prostatectomy, and continence revisited显示文摘 | Milhoua P M Koi P T Lowe D | 2008 | Urology2008，71，： | 1 |
| 14 | Electrodeposition of Cu-In-Ga thin metal films for Cu(In,Ga)Se2 based solar cells显示文摘 | KOIS J GANCHEV M KAELIN M | | 0，，18： | 1 |
| 15 | Role of oncogenes and tumor suppressor genes in a multistep model of carcinogenesis显示文摘 | Barrett JC Oshimura M Koi M | | 0，，： | 1 |
| 16 | Tumor hypoxia and genetic alterations in spo- radic cancers 显示文摘 | Koi M Boland CR | 2011 | J Obstet Gynaeeol Res2011，37，2： | 1 |
| 17 | Allelotype of uterine cancer by analysis of RFLP and microsatellie polymorphisms: frequent loss of heterozygosity on chromosome arms 3p, 9q, 10q, and 17p 显示文摘 | Jones M H Koi S Fujimoto I | 1994 | Genes Chromosome Cancer1994，9，2： | 1 |
| 18 | Placental extravillous cytotrophoblasts persistently express class I major histocompatibility complex molecules after human cytomegalovirus infection显示文摘 | Koi H Hayano C | 2003 | J Virol2003，77，： | 1 |
| 19 | The biochemical basis of mierosatellite instability and abnormal immunohistochemistry and clinical behavior in Lynch syndrome显示文摘 | Boland C Koi M Chang D | 2008 | Fam Cancer2008，7，： | 1 |
| 20 | Ele,-qronmgnelic modeling of comlpo-sile melallie and dieleelric structures 显示文摘 | KOI ITNDZIJA B M | 1999 | IEEE Trans Microwave Theory and Tec1999，47，7： | 1 |
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