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| 1 | B7-H7 (HHLA2) inhibits T-cell activation and proliferation in the presence of TCR and CD28 signaling显示文摘Modulation of T-cell responses has played a key role in treating cancers and autoimmune diseases.Therefore,understanding how different receptors on T cells impact functional outcomes is crucial.The influence of B7-H7(HHLA2)and CD28H(TMIGD2)on T-cell activation remains controversial.Here we examined global transcriptomic changes in human T cells induced by B7-H7.Stimulation through TCR with OKT3 and B7-H7 resulted in modest fold changes in the expression of select genes;however,these fold changes were significantly lower than those induced by OKT3 and B7-1 stimulation.The transcriptional changes induced by OKT3 and B7-H7 were insufficient to provide functional stimulation as measured by evaluating T-cell proliferation and cytokine production.Interestingly,B7-H7 was coinhibitory when simultaneously combined with TCR and CD28 stimulation.This inhibitory activity was comparable to that observed with PD-L1.Finally,in physiological assays using T cells and APCs,blockade of B7-H7 enhanced T-cell activation and proliferation,demonstrating that this ligand acts as a break signal.Our work defines that the transcriptomic changes induced by B7-H7 are insufficient to support full costimulation with TCR signaling and,instead,B7-H7 inhibits T-cell activation and proliferation in the presence of TCR and CD28 signaling. | Sadiye Amcaoglu Rieder Jingya Wang Natalie White Ariful Qadri Catherine Menard Geoffrey Stephens Jodi LKarnell Christopher ERudd Roland Kolbeck | 2021 | Cellular & Molecular Immunology2021，18，6： | 9 |
| 2 | 壳牌对未来车用能源多元化发展趋势的思考显示文摘面对能源短缺和环境污染的双重挑战,交通领域的转型升级不可避免。本文结合未来车用动力系统的发展趋势,对交通运输领域中应用的多种先进动力系统、清洁能源及替代燃料进行综述和评价,包括目前主要使用的传统液态化石燃料即汽、柴油及先进内燃机技术,清洁替代燃料(如生物燃料、天然气合成油(GTL)燃料、电转液(PTL)燃料、液化天然气(LNG)等),以及电气化动力系统(包括混合动力、纯电动和燃料电池)等,并着重讨论液体燃料。壳牌认为没有一种单一的解决方案可以解决复杂的能源问题,未来交通能源结构将呈现多种能源并存的特点,并分别适用于不同的场景。该文还介绍了壳牌近期基于不同政治、经济和社会发展程度提出的3种远景(壳牌“高山”、“海洋”和“天空”远景),提出壳牌对未来车用能源领域转型脱碳发展情景的思考。 | 贾恬 郑彬 Warnecke W Kolbeck A Aradi A Kofod M Clark R Wilbrand K | 2020 | 汽车安全与节能学报2020，11，1： | 2 |
| 3 | Noncanonical autophagy: one small step for LC3, one giant leap for immunity显示文摘 | Payal Mehta Jill Henault Roland Kolbeck Miguel A Sanjuan | 2014 | Current Opinion in Immunology2014，，： | 2 |
| 4 | Systemic application of growth hormone for enhancement of secondary and intramembranous fracture healing显示文摘 | Bail H J Kolbeck S Krummrey G | 2002 | Honn Res2002，58，3： | 1 |
| 5 | Wear performance of substructure ce- ramics and veneering porcelains 显示文摘 | Preis V Behr M Kolbeck C | 2011 | Dent Mater2011，27，8： | 1 |
| 6 | Neurotrophin-3 enhances sprouting of cortieospinal tract during development and after spinal cord lesion显示文摘 | Schnell L Schneider R Kolbeck R | 1994 | Nature1994，367，： | 1 |
| 7 | SyStemic application of growth hormone for enhancement of secondary and intramembranous fracture healing显示文摘 | Bail HJ Kolbeck S Krummrey G | 2002 | Horm Res2002，，58： | 1 |
| 8 | Homologous growth hormone accelerates healing of segmental bone defects 显示文摘 | Raschke M Kolbeck S Bail H | 2001 | Bone2001，29，4： | 1 |
| 9 | The effect of growth hormone on insulin-like growth factor Ⅰ and bone metabolism in distraction osteogenesis 显示文摘 | Bail HJ Kolbeck S Lindner T | 2001 | Growth Horm IGF Res2001，11，5： | 1 |
| 10 | Recombinant species-specific growth hormone increases hard callus fprmation in distraction osteogensis显示文摘 | Bail HJ Raschke M J Kolbeck S | 2002 | Bone2002，30，1： | 1 |
| 11 | Neurotrophin-3 enhances sprouting of corticespinal tract during development and after spinal cord lesion显示文摘 | Schnell L Schneider R Kolbeck R | 1994 | Nature1994，367，6459： | 1 |
| 12 | Benign human enterovirus becomes virulent in selenium-deficient mice显示文摘 | Beck MA Kolbeck PC Rohr LH | 1994 | J Med Virol1994，43，2： | 1 |
| 13 | MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibodydependent cell- mediated cytotoxicity function 显示文摘 | Kolbeck R Kozhich A Koike M | 2010 | J Allergy Clin Immunol2010，125，6： | 1 |
| 14 | Neurotropin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion 显示文摘 | Schnell L Schneider R Kolbeck R | 1994 | Nature1994，367，6549： | 1 |
| 15 | Vitamin E deficiency intensifies the myocardial injury of coxsackievirus B3 infection of mice显示文摘 | Beck MA Kolbeck PC Rohr LH | 1994 | J Nutr1994，124，3： | 1 |
| 16 | Use of fly ash slurry of underground facility construction显示文摘 | RAMME B W NAIK T R KOLBECK J | 1994 | Construction and Building Materials1994，8，1： | 1 |
| 17 | Noncanonical autopha- gy: one small step for LC3, one giant leap for immunity显示文摘 | Mehta P Henanlt J Kolbeck R | 2014 | Curt Opin Immunol2014，26，： | 1 |
| 18 | Fracture characteristics of an- terior resin-bonded zirconia-fixed partial dentures 显示文摘 | Rosentritt M Ries S Kolbeck C | 2009 | Clin Oral Investig2009，13，4： | 1 |
| 19 | Discoloration of facing and restorative composites by UV-irradiation and staining food显示文摘 | Kolbeck C Rosentritt M Lang R | 2006 | Dent Mater2006，22，1： | 1 |
| 20 | Recombinant species-specific growth hormone increases hard callus formation in distraction osteogenesis显示文摘 | Bail H J Raschke M J Kolbeck S | 2002 | Bone2002，30，1： | 1 |
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