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| 1 | Viral hepatitis prevalence in patients with active and latent tuberculosis显示文摘AIM: To assess the prevalence of hepatitis B virus(HBV) and hepatitis C virus(HCV) infection and association with drug induced liver injury(DILI) in patients undergoing anti-tuberculosis(TB) therapy.METHODS: Four hundred and twenty nine patients with newly diagnosed TB- either active disease or latent infection- who were due to commence antiTB therapy between September 2008 and May 2011 were included. These patients were prospectively tested for serological markers of HBV, HCV and human immunodeficiency virus(HIV) infections- hepatitis B core antigen(HBc Ag), hepatitis B surface antigen(HBs Ag), hepatitis B e antigen, Ig G and Ig M antibody to HBc Ag(anti-HBc), HCV Ig G antibody and HIV antibody using a combination of enzyme-linked immunosorbent assay, Western blot assay and polymerase chain reaction techniques. Patients were reviewed at least monthly during the TB treatment initiation phase. Liver function tests were measured prior to commencement of antiTB therapy and 2-4 wk later. Liver function tests were also performed at any time the patient had significant nausea, vomiting, rash, or felt non-specifically unwell. Fisher's exact test was used to measure significance in comparisons of proportions between groups. A P value of less than 0.05 was considered statistically significant.RESULTS: Of the 429 patients, 270(62.9%) had active TB disease and 159(37.1%) had latent TB infection. 61(14.2%) patients had isolated anti-HBc positivity, 11(2.6%) were also HBs Ag positive and 7(1.6%) were HCV-antibody positive. 16/270 patients with active TB disease compared to 2/159 patients with latent TB infection had markers of chronic viral hepatitis(HBs Ag or HCV antibody positive; P = 0.023). Similarly the proportion of HBs Ag positive patients were significantly greater in the active vs latent TB infection group(10/43 vs 1/29, P = 0.04). The prevalence of chronic HBV or HCV was significantly higher than the estimated United Kingdom prevalence of 0.3% for each. We found no association between DILI and presence of serological markers of HBV or HCV. Three(5.3%) patients with serological markers of HBV or HCV infection had DILI compared to 25(9.5%) patients without; P = 0.04.CONCLUSION: Viral hepatitis screening should be considered in TB patients. DILI risk was not increased in patients with HBV/HCV. | Hesam Ahmadi Nooredinvand David W Connell Mahmoud Asgheddi Mohammed Abdullah Marie O'Donoghue Louise Campbell Melissa I Wickremasinghe Ajit Lalvani Onn Min Kon Shahid A Khan | 2015 | World Journal of Gastroenterology2015，21，29： | 7 |
| 2 | Antioxidant and antimicrobial properties of Moltkia petraea (Tratt.) Griseb. flower, leaf and stem infusions显示文摘 | M. Zovko Kon?i? D. Kremer J. Gruz M. Strnad G. Bi?evac I. Kosalec D. ?amec J. Piljac-?egarac K. Karlovi? | 2010 | Food and Chemical Toxicology2010，，6： | 4 |
| 3 | Correlation between serum carnitine levels and erythrocyte osmotic fragility in hemodialysis patients显示文摘 | Mastsumura M Hatakeyama S Kon I | 1996 | Nephron1996，72，4： | 1 |
| 4 | Anthraquinone profiles, antioxidant and antimicrobial properties of Frangula rupestris (Scop.) Schur and Frangula alnus Mill. bark显示文摘 | D. Kremer I. Kosalec M. Locatelli F. Epifano S. Genovese G. Carlucci M. Zovko Kon?i? | 2011 | Food Chemistry2011，，4： | 1 |
| 5 | Autologous bone marrow stromal cells loaded onto porous hydroxyapatite ceramic accelerate bone repair in critical-size defects of sheep long bones显示文摘 | Kon E Muraglia A Corsi A Bianco P Marcacci M Martin I Boyde A Ruspantini I Chistolini P Rocca M Giardino R Cancedda R Quarto R | | 0，，： | 1 |
| 6 | Osteomyelitis in cat scratch disease: a case report and literature review 显示文摘 | Dusser P Eyssette-Guerrean S Kon 6 -Paut I | 2013 | Arch Pediatr2013，20，6： | 1 |
| 7 | Portable power source based on air-hydrogen fuel cells with free-breathing cathodes显示文摘 | GUREVICH S A TERUKOV E I KON′KOV O I | 2011 | Technical Physics Letters2011，37，5： | 1 |
| 8 | On the displacement of spatially bounded light beams in a turbulent medium in the markovian- random-process approximation显示文摘 | Klyatskin V I Kon A I | 1972 | Radiofiz Quantum Electron1972，15，： | 1 |
| 9 | Correlatiofi between serum camitine levels and erythrocyte osmotic fragility in hemodialysis patients显示文摘 | Mastsumura M Hatakeyama S Kon I | 1996 | Nephron1996，72，1： | 1 |
| 10 | Evaluation of antioxidant activities and phenolic content of Berberis vulgaris L. and Berberis croatica Horvat显示文摘 | M. Zovko Kon?i? D. Kremer K. Karlovi? I. Kosalec | 2010 | Food and Chemical Toxicology2010，，8： | 1 |
| 11 | Reaetiwe haemophagocytic syndrome in children with inflammatory disorders: a retrospective study of 24 patients 显示文摘 | St e phan JL Kon e -Paul I Calambrum C | 2001 | Rheumatology (Oxford)2001，40，11： | 1 |
| 12 | A dynamic role of HAUSP in the p53-Mdm2 Pathway显示文摘 | MUYANG L I CHRISTOPHER L BROOKS NING KON | 2004 | Molecular Cell2004，13，： | 1 |
| 13 | Anodic2spark deposition of P and W(Mo)-containing coatings onto aluminum and titanium alloys显示文摘 | Lukiyanchuk I V Kon' shin V V | 2002 | Russian Journalf Applied Chemistry2002，75，7： | 1 |
| 14 | Polymorphisrn s of the reninangiotensin systeln-genes in progressive renal diseases显示文摘 | Yoshida H Kon V Ichikawa I | 1996 | Kidney Int1996，50，： | 1 |
| 15 | The nutritional status of children in intensive care units 显示文摘 | Uglitskikh A K Kon'lla Ostrel'kov I F | 2008 | Anesteziol Reanimatol2008，，1： | 1 |
| 16 | Bradykinin cause selective efferent arteriolar dilation during angiotensin I converting enzyme 显示文摘 | Kon V Fogo A Ichikawa I | 1993 | Kid Int1993，44，： | 1 |
| 17 | Oscillation criteria for delay equations显示文摘 | SFICAS Y G STAVROULAKIS I P | 2000 | Proc Amer Math Soc2000，168，： | 1 |
| 18 | Relationships between flowering time and rainfall gradients across Mediterranean Desert transects 显示文摘 | Kigel J Konsens I Rosen N Rotem G Kon A Fragman-Sapir O | 2011 | Israel J Ecol Evol2011，57，： | 1 |
| 19 | Effect of Excess Vitamin A Intake on State of The Epithelium of The Rat Small Intetsine显示文摘 | Gadzhieva Z M Kon Y I | 1984 | Byulleten'' Eksperimental''noi Biologii Meditsiny1984，97，： | 1 |
| 20 | Plasma and macular responses to lutein supplement in subjects with and without age-related maculopathy: a pilot study显示文摘 | KON H H MURRAY I J NOLAN D | 2004 | Exp Eye Res2004，79，： | 1 |
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