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| 1 | 皮质下小血管病诊断的共识声明显示文摘血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病(Binswanger's disease, BD)的进行性白质损害患者构成了从单纯血管性疾病到合并神经变性病变的疾病谱。BD患者是一个相对同质性的亚组,存在缺氧缺血、腔隙性梗死和炎症,它们协同作用破坏血脑屏障和髓鞘。通过临床、脑脊液、神经心理学和影像学检查获得的多模式疾病标记物能促进该亚组患者的鉴别。本共识声明确定了一系列基于基础病理学改变的潜在生物学标记物,这将有助于诊断以及将来协作性治疗试验的患者选择。 | Gary A Rosenberg Anders Wallin Joanna M Wardlaw Hugh S Markus Joan Montaner Leslie Wolfson Costantino Iadecola Berislav V Zlokovic Anne Joutel Martin Dichgans Marco Duering Reinhold Schmidt Amos D Korczyn Lea T Grinberg Helena C Chui Vladimir Hachinski 王训师 张劼 陈涵丰 俞娅美 徐子奇 罗本燕 | 2016 | 国际脑血管病杂志2016，24，6： | 18 |
| 2 | Can Biomarkers Help the Early Diagnosis of Parkinson's Disease?显示文摘Parkinson's disease(PD) is a complex neurodegenerative disease with progressive loss of dopamine neurons. PD patients usually manifest a series of motor and non-motor symptoms. In order to provide better early diagnosis and subsequent disease-modifying therapies for PD patients, there is an urgent need to identify sensitive and specific biomarkers. Biomarkers can be divided into four categories: clinical, imaging, biochemical, and genetic. Ideal biomarkers not only improve our understanding of PD pathogenesis and progression, but also provide benefits for early risk evaluation and clinical diagnosis of PD. Although many efforts have been made and several biomarkers have been extensively investigated,few if any have been found useful for early diagnosis.Here, we summarize recent developments in the discoveredbiomarkers of PD and discuss their merits and limitations for the early diagnosis of PD. | Weidong Le Jie Dong Song Li Amos D. Korczyn | 2017 | Neuroscience Bulletin2017，33，5： | 2 |
| 3 | Mild cognitive impairment: conceptual, assessment, ethical, and social issues显示文摘 | Werner P Korczyn AD | 2008 | Clin Interv Aging2008，3，3： | 1 |
| 4 | Retinal thickness in patients with mild cognitive impairment and Alzheimers' s disease 显示文摘 | Kesler A Vakhapova V Korczyn AD | 2011 | Clin Neurot Neurosurg2011，113，7： | 1 |
| 5 | Parkinsonism in patients with lacunar infarcts of the basal ganglia 显示文摘 | Reider-Groswasser Ⅰ Bomstein NM Korczyn AD | 1995 | Eur Neurol1995，35，： | 1 |
| 6 | Anal sphincter EMG does not distinguish between multiple system atrophy and Parkinsons disease显示文摘 | Giladi N Simon E S Korczyn A D | 2000 | Muscle Nerve2000，23，5： | 1 |
| 7 | A five-year study of the incidence of dyskinesia in patients with early Parkinson's disease who were treated with ropinirole or levodopa显示文摘 | Rascol O Brooks DJ Korczyn AD | 2000 | N Engl J Med2000，342，： | 1 |
| 8 | Parkin mutation associated parkinsonism and cognitive decline, comparison to early onset Parkinson' s disease显示文摘 | Benbunan BR Korczyn AD Giladi N | 2004 | Neural Transm2004，111，： | 1 |
| 9 | The prevention of the dementia epidemic 显示文摘 | Korczyn AD Vakhapova V | 2007 | J Neurol Sci2007，257，12： | 1 |
| 10 | Mixed Dementia-the most common cause of dementia显示文摘 | Korczyn AD | 2002 | Ann N Y AcaD Sci2002，977，： | 1 |
| 11 | A five-year study of the incidence of dyskinesia in patients with early Parkinson's disease who were treated with ropinirole or levodopa显示文摘 | Rascol O Brooks D Korczyn A | 2000 | N Engl J Med2000，342，： | 1 |
| 12 | The prevention of the de- mentia epidemic显示文摘 | Korczyn AD Vakhapova V | 2007 | J Neurol Sci2007，257，12： | 1 |
| 13 | Commentary on 'Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnost ic guidel ines for Alzheimer's disease'显示文摘 | Korczyn AD | | Alzheimer's & Dementia0，，： | 1 |
| 14 | Thrombin receptor PAR-1 on myelin at the node of Ranvier:a new anatomy and physiology of conduction block显示文摘 | Shavit E Beilin O Korczyn A D | 2008 | Brain2008，131，： | 1 |
| 15 | Anal sphincter EMG does not distinguish between multiple system atrophy and Parkinsons disease显示文摘 | GILADI N SIMON E S KORCZYN A D | 2000 | Muscle Nerve2000，23，5： | 1 |
| 16 | The Prevention of the demen- tia epidermic 显示文摘 | Korczyn AD VakhaPova V | 2007 | J Neurol Sci2007，257，12： | 1 |
| 17 | Depression and dementia 显示文摘 | Korczyn AD Halperin I | 2009 | J Neurol Sci2009，283，12： | 1 |
| 18 | Vascular dementia显示文摘 | Amos D. Korczyn Veronika Vakhapova Lea T. Grinberg | 2012 | Journal of the Neurological Sciences . 2012 (1-2)2012，，1： | 1 |
| 19 | Parkinsonism in patients with lucanar infarcts of the basal ganglia显示文摘 | Reider-Groswasser I Bornstein N M Korczyn A D | | 0，，01： | 1 |
| 20 | EEG changes during long term treatment with donepezil in Alzheimer's disease patients显示文摘 | Kogan EA Korczyn AD Virchovsky RG | 2001 | J Neural Transm2001，108，10： | 1 |
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