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| 1 | Antioxidative phytoceuticals to ameliorate pancreatitis in animal models: An answer from nature显示文摘Despite enthusiastic efforts directed at elucidating critical underlying mechanisms towards the identification of novel therapeutic targets for severe acute pancreatitis(SAP), the disease remains without a specific therapy to be executed within the first hours to days after onset of symptoms. Although earlier management for SAP should aim to either treat organ failure or reduce infectious complications, the current standard of care for the general management of AP in the first hours to days after onset of symptoms include intravenous fluid replacement, nutritional changes, and the use of analgesics with a close monitoring of vital signs. Furthermore, repeated evaluation of severity is very important, as the condition is particularly unstable in the early stages. In cases where biliary pancreatitis is accompanied by acute cholangitis or in cases where biliary stasis is suspected,an early endoscopic retrograde cholangiopancreatography is recommended.However,practice guidelines regarding the treatment of pancreatitis are suboptimal.In chronic pancreatitis,conservative management strategies include lifestyle modifications and dietary changes followed by analgesics and pancreatic enzyme supplementation.Recently,attention has been focused on phytoceuticals or antioxidants as agents that could surpass the limitations associated with currently available therapies.Because oxidative stress has been shown to play an important role in the pathogenesis of pancreatitis,antioxidants alone or combined with conventional therapy may improve oxidativestress-induced organ damage.Interest in phytoceuticals stems from their potential use as simple,accurate tools for pancreatitis prognostication that could replace older and more tedious methods.Therefore,the use of antioxidative nutrition or phytoceuticals may represent a new direction for clinical research in pancreatitis.In this review article,recent advances in the understanding of the pathogenesis of pancreatitis are discussed and the paradigm shift underway to develop phytoceuticals and antioxidants to treat it is introduced.Despite the promise of studies evaluating the effects of antioxidants/phytoceuticals in pancreatitis,translation to the clinic has thus far been disappointing.However,it is expected that continued research will provide solid evidence to justify the use of antioxidative phytoceuticals in the treatment of pancreatitis. | Jong-Min Park Sooyeon Lee Mi Kyung Chung Sung-Hun Kwon Eun-Hee Kim Kwang Hyun Ko Chang Il Kwon Ki Baik Hahm | 2014 | World Journal of Gastroenterology2014，20，44： | 5 |
| 2 | Diagnostic Indicators for Blood Stasis Syndrome Patients with Gynaecological Diseases显示文摘Objective: To investigate the important diagnostic indicators for blood stasis syndrome(BSS) in patients of childbearing age with gynaecological diseases. Methods: A partial least squared-discriminant analysis(PLS-DA) were applied to BSS symptoms data of patients with gynaecological diseases, and the diagnostic indicators used by doctors of Korean medicine(DKMs) among BSS patients with gynaecological diseases were also investigated. Results: A total of 103 patients of childbearing age with gynaecological diseases and 40 healthy controls were enrolled. Among the 103 patients, 63(61.7%) and 40(38.8%) were diagnosed with BSS and non-BSS, respectively, and BSS patients exhibited a more severe extent of disease. A score plot of PLS-DA showed clearly different patterns among the 3 groups. Based on the variable importance on projection of PLS-DA model, menstrual pains, dark lumps in the menstrual blood, ileocoecal tenderness and resistance, sharp pains, and sublingual varicosities were selected as the top five most important indicators. Moreover, more than 75% of DKMs chose dark lumps in menstrual blood, menstrual pain, and dark menstrual blood as the diagnostic indicators of BSS in patients with gynaecological diseases, and more than 49% of them also considered sharp pains, dark red tongue, sublingual varicosities, and tendency to bruise easily as diagnostic indicators of BSS. Conclusion: DKMs focused on menstrual symptoms and certain gynaecological symptoms to diagnose BSS patients of childbearing age with female diseases. | Jeeyoun Jung Mi Mi Ko Myeong Soo Lee So Min Lee Ju Ah Lee | 2018 | Chinese Journal of Integrative Medicine2018，24，10： | 3 |
| 3 | A case of a duodenal duplication cyst presenting as melena显示文摘Duodenal duplication cysts are benign rare congenital anomalies reported mainly in the pediatric population,but seldom in adults.Symptoms depend on the type and location and can present as abdominal pain,distension,dysphagia or dyspepsia.They have been reported to be responsible for duodenal obstruction,pancreatitis and,in rare cases,gastrointestinal bleeding.We present a case of a duodenal duplication cyst in a 43-year-old man presenting as melena.Initial gastroduodenoscopy and colonoscopy did not reveal any bleeding focus.However,the patient began passing melena after 3 d,with an acute decrease in hemoglobin levels.Subsequent studies revealed a duplication cyst in the second portion of the duodenum which was surgically resected.Histology revealed a duodenal duplication cyst consisting of intestinal mucosa.There was no further bleeding and the patient recovered completely.In rare cases,duodenal duplication cysts might cause gastrointestinal bleeding and should be included in the differential diagnosis. | Seung Yeon Ko Sun Hye Ko Sungeun Ha Mi Sung Kim Hyang Mi Shin Myong Ki Baeg | 2013 | World Journal of Gastroenterology2013，19，38： | 2 |
| 4 | Undiagnosed Borrmann type Ⅱ gastric cancer due to necrosis and regenerative epithelium显示文摘Endoscopic biopsy is essential to the proper diagnosis and treatment of gastric cancer.Unfortunately,the results of endoscopic biopsy are not always the same as what is expected based on gross endoscopic findings.The results of endoscopic biopsy can be negative for malignancy in Borrmann typeⅣadvanced gastric cancer(AGCa)or gastric lymphoma.However,in the case of typeⅡAGCa,repeated biopsies negative for malignancy have not been reported.A 49-year-old male patient underwent esophagogastroduodenoscopy three times due to large gastric ulcer suspected to be Borrmann typeⅡcancer.However,three repeat endoscopic biopsies with multiple specimens showed necrosis and superficial regenerative epithelium without malignant findings.The patient underwent laparoscopic distal gastrectomy with D2 lymph node dissection.The surgical specimen revealed that the mucosal layer was completely replaced with regenerative epithelium without cancer cells. | Joon Hur Jae Hyuck Chang Byung Kee Kim Hoon Young Ko Jong Hwan Lee Soo Jeong Kim Mi Ae Song Tae Ho Kim Chang Whan Kim Sok Won Han | 2014 | World Journal of Gastroenterology2014，20，28： | 2 |
| 5 | Safe drug treatment and procedure for herpes zoster in pregnancy:a case report显示文摘To the Editor:A first infection of varicella-zoster virus(VZV)during pregnancy can cause serious systemic disease to both mother and the fetus.Despite this maternal herpes zoster(HZ)does not increase fetal mortality,and the transmission of varicella-zoster virus to the fetus rarely occurs.Although HZ infection has a minimal effect on the fetus,maternal HZ can cause significant complications for the mother. | Ji Yeong Kim You Ri Ko Sung Eun Sim Sua Oh Mi Hyeon Lee Hue Jung Park | 2020 | Chinese Medical Journal2020，，16： | 2 |
| 6 | The Significance of Blood Pressure Variability for the Development of Hemorrhagic Transformation in Acute Ischemic Stroke显示文摘 | Youngchai Ko Jung Hyun Park Mi Hwa Yang Sang-Bae Ko Moon-Ku Han Chang Wan Oh JiSung Lee Juneyoung Lee Hee-Joon Bae | 2010 | Stroke2010，，11： | 2 |
| 7 | Clinical correlations of infliximab trough levels and antibodies to infliximab in South Korean patients with Crohn's disease显示文摘AIM To investigate the clinical implications of infliximab trough levels(IFX-TLs) and antibodies to infliximab(ATI) levels in Crohn's disease(CD) patients in Asian countries. METHODS IFX-TL and ATI level were measured using prospectively collected samples obtained with informed consent from CD patients being treated at Asan Medical Center, South Korea. We analyzed the correlations between IFX-TLs/ATI levels and the clinical activity of CD(quiescent vs active disease) based on the CD activity index, C-reactive protein level, and physician's judgment of patients' clinical status at enrollment. The impact of concomitant immunomodulators was also investigated. RESULTS This study enrolled 138 patients with CD(84 with quiescent and 54 with active disease). In patients with quiescent and active diseases, the median IFX-TLs were 1.423 μg/mL and 0.163 μg/mL, respectively(P < 0.001) and the median ATI levels were 8.064 AU/m L and 11.209 AU/m L, respectively(P < 0.001). In the ATI-negative and-positive groups, the median IFXTLs were 1.415 μg/mL and 0.141 μg/mL, respectively(P < 0.001). In patients with and without concomitant immunomodulator use, there were no differences in IFX-TLs(0.632 μg/mL and 1.150 μg/mL, respectively; P = 0.274) or ATI levels(8.655 AU/mL and 9.017 AU/mL, respectively; P = 0.083).CONCLUSION IFX-TL/ATI levels were well correlated with the clinical activity in South Korean CD patients. Our findings support the usefulness of IFX-TLs/ATI levels in treating CD patients receiving IFX in clinical practice. | Eun Hye Oh Dae-Hyun Ko Hyungil Seo Kiju Chang Gwang-Un Kim Eun Mi Song Myeongsook Seo Ho-Su Lee Sung Wook Hwang Dong-Hoon Yang Byong Duk Ye Jeong-Sik Byeon Seung-Jae Myung Suk-Kyun Yang Sang Hyoung Park | 2017 | World Journal of Gastroenterology2017，23，8： | 2 |
| 8 | Electrical acustimulation of the wrist for chronic neck pain: a randomized, sham- controlled trial using a wrist - ankle acustimulation device显示文摘 | Chan DK Johnson MI Sun KO | 2009 | Clin J Pain2009，25，4： | 1 |
| 9 | Dravet syndrome-considerable delay in making the diagnosis显示文摘 | Biemer A Lossius MI Nakken KO | | 0，，： | 1 |
| 10 | The Hajek - Renyi inequality for the AANA random variables and its applications 显示文摘 | Mi Hua Ko Tae Sung Kim Zheng Yan Lin | 2005 | Taiwanese Journal of Mathematics2005，9，： | 1 |
| 11 | Prediction of the Effect of Injected Ethanol on Pulmonary Arterial Pressure during Sclerotherapy of Arteriovenous Malformations: Relationship with Dose of Ethanol显示文摘 | Justin S. Ko Jie A. Kim Young S. Do Min A. Kwon Soo J. Choi Mi S. Gwak Jeong J. Lee Mikyung Yang | 2009 | Journal of Vascular and Interventional Radiology2009，，1： | 1 |
| 12 | Mucosal dendritic cells shape mucosal immunity 显示文摘 | Sun - Young Chang Hyun - Jeong Ko Mi - Na Kweon | 2014 | Experimental & Molec- ular Medicine2014，46，1： | 1 |
| 13 | Buccal midazolam or rectal diazepam for treatment of residential adult patients with serial seizures or status epilepticus显示文摘 | NAKKEN KO LOSSIUS MI | 2011 | Acta Neural Seand2011，124，2： | 1 |
| 14 | Dravet syndrome--considerable delay in making the diagnosis 显示文摘 | BREMER A LOSSIUS MI NAKKEN KO | 2012 | Acta Neurol Scand2012，125，5： | 1 |
| 15 | Dramatically Different Phenotypic Expressions of Hypertrophic Cardiomyopathy in Male Cousins Undergoing Cardiac Transplantation With Identical Disease-Causing Gene Mutation显示文摘 | William C. Roberts Carey Camille Roberts Jong Mi Ko Paul A. Grayburn Anumeha Tandon Johannes J. Kuiper John E. Capehart Shelley A. Hall | 2013 | The American Journal of Cardiology2013，，： | 1 |
| 16 | Alpha-thalassemia in the four major aboriginal groups in Taiwan 显示文摘 | Ko TM Chen TA Hsieh MI | 1993 | Hum Genet1993，92，1： | 1 |
| 17 | In vivo biocompatibility study of electrospun ehitosan mierofiber for tissue engineering 显示文摘 | Yun Mi Kang Bit Na Lee Jae Hoon Ko | 2010 | International Journal of Molecular Sciences2010，11，10： | 1 |
| 18 | Genetic Association of NPY Gene Polymorphisms with Dampness-Phlegm Pattern in Korean Stroke Patients显示文摘 | Mi Mi Ko Byoung Kab Kang Ji Hye Lim Myeong Soo Lee Min Ho Cha Jae Youl Cho | 2011 | Evidence-Based Complementary and Alternative Medicine2011，，： | 1 |
| 19 | Alpha-thalassemia in the four major aboriginal groups in Taiwan显示文摘 | Ko TM Chen TA Hsieh MI | 1993 | Hum Genet1993，92，1： | 1 |
| 20 | Alpha-thalassemia in the four major aboriginal groups in Taiwan 显示文摘 | Ko TM Chen TA Hsieh MI | 1993 | Hum Genet1993，92，1： | 1 |
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