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| 1 | Modulation of protein tyrosine phosphorylation in gastric mucosa during re-epithelization processes显示文摘AIM:To investigate the role of protein tyrosine phosphorylation in gastric wound formation and repair following ulceration. METHODS:Gastric lesions were induced in rats using restraint cold stress.To investigate the effect of oxidative and nitrosative cell stress on tyrosine phosphorylation during wound repair,total activity of protein tyrosine kinase(PTK),protein tyrosine phosphatase (PTP),antioxidant enzymes,nitric oxide synthase (NOS), 2',5'-oligoadenylate synthetase,hydroxyl radical and zinc levels were assayed in parallel. RESULTS:Ulcer provocation induced an immediate decrease in tyrosine kinase(40% in plasma membranes and 56% in cytosol,(P<0.05) and phosphatase activity (threefold in plasma membranes and 3.3-fold in cytosol),followed by 2.3-2.4-fold decrease (P<0.05) in protein phosphotyrosine content in the gastric mucosa. Ulceration induced no immediate change in superoxide dismutase (SOD) activity,30% increase (P<0.05) in catalase activity,2.3-fold inhibition (P<0.05) of glutathione peroxidase,3.3-fold increase (P<0.05) in hydroxyl radical content,and 2.3-fold decrease (P<0.05) in zinc level in gastric mucosa.NOS activity was three times higher in gastric mucosa cells after cold stress. Following ulceration,PTK activity increased in plasma membranes and reached a maximum on day 4 after stress (twofold increase,P<0.05),but remained inhibited(1.6-3-fold decrease on days 3,4 and 5,P<0.05) in the cytosol.Tyrosine phosphatases remained inhibited both in membranes and cytosol(1.5-2.4-fold,P< 0.05).NOS activity remained increased on days 1,2 and 3(3.8-,2.6-,2.2-fold,respectively,P<0.05).Activity of SOD increased 1.6 times(P<0.05)days 4 and 5 after stress.Catalase activity normalized after day 2. Glutathione peroxidase activity and zinc level decreased (3.3-and 2-fold,respectively,P<0.05)on the last day. Activity of 2',5'-oligoadenylate synthethase increased 2.8-fold (P<0.05) at the beginning,and 1.6-2.3-fold (P<0.05) during ulcer recuperation,and normalized on day 5,consistent with slowing of inflammation processes. CONCLUSION:These studies show diverse changes in total tyrosine kinase activity in gastric mucosa during the recovery process.Oxidative and nitrosative stress during lesion formation might lead to the observed reduction in tyrosine phosphorylation during ulceration. | Olena V Bogdanova Larysa I Kot Kateryna V Lavrova Volodymyr B Bogdanov Erica K Sloan Tetyana V Beregova Ludmyla I Ostapchenko | 2010 | World Journal of Biological Chemistry2010，1，11： | 2 |
| 2 | Eigenfeature regularization and extraction in face recognition显示文摘 | Jiang X Mandal B Kot A | 2008 | Transactions on Pattern Analysis and Machine Intelligence2008，30，3： | 1 |
| 3 | A flexible array synthesis method using quadratic - programming 显示文摘 | NG B P ER M H KOT C | 1993 | IEEE Transactions on Antennas Propagation1993，41，11： | 1 |
| 4 | Eigenfeature regularization and extraction in face recognition显示文摘 | Jiang X Mandal B Kot A | 2008 | IEEE Trans Pattern Analysis and Machine Intelligence2008，30，3： | 1 |
| 5 | The composition and properties of purified rapeseed lecithins显示文摘 | M Sosada B Pasker K Kot | 1992 | Fat Sci Technol1992，94，： | 1 |
| 6 | Design and analysis for interferometric measurements of the GMT primary mirror segments显示文摘 | BURGE J H KOT L B MARTIN H M | 2006 | SPIE2006，6273，： | 1 |
| 7 | Advances in passive sampling in environmentalstudies显示文摘 | Kot'Wasik A Zabiegala B Urbanowicz M | 2007 | Analytica Chimica Acta2007，602，2： | 1 |
| 8 | Passive sampling for long-term monitoring of organic pollutants in water 显示文摘 | KOT A ZABIEGALA B NAMIESNIK J | 2000 | Trends in Analytical Chemistry2000，19，7： | 1 |
| 9 | Eigenfeature regularization and extraction in face recognition显示文摘 | Jiang Xudong Mandal B ChiChung Kot A | 2008 | IEEE Trans on Pattern Anal Mach Intell2008，30，3： | 1 |
| 10 | 3-D fluid-mud dy- narnics in the Jiaojiang Estuary, China显示文摘 | Guan W B Kot S C Wolanski E | 2005 | Estuarine Coastal and Shelf Science2005，65，4： | 1 |
| 11 | 显示文摘 | Wolska K Kot B Piechota M | 2013 | Postepy higieny i mcdycyny doswiadczalnej2013，67，13： | 1 |
| 12 | Passive sampling for long-term monitoring of organic pollutants in water显示文摘 | Zabiegala B Namiesnik J | 2000 | Trends in Analytical Chemistry2000，19，： | 1 |
| 13 | Twitching motility activity, biofilm for- mation, and genetic typing for clinical isolates of Pseudo- monas aeruginosaby random amplified DNA PCR显示文摘 | Wolska K Kot B | 2013 | Ac- ta Microbiol Immunol Hung2013，60，3： | 1 |
| 14 | A flexible array synthesis method using quadratic programming显示文摘 | Ng B P Er M H Kot C | 1993 | IEEE Trans on AP1993，41，11： | 1 |
| 15 | Determination of soil impedance functions from vibration-test response of a circular foundation显示文摘 | Srinivasan M G Kot C A Hsieh B J | 1991 | Soil Dynamics and Earthquake Engrg1991，10，： | 1 |
| 16 | Susceptibility of Eseherichia coli strains isolated frompersons with urinary tract infections in 2007 - 2008 to antimicrobial agents 显示文摘 | Kot B Wicha J Z~tk-Pulawska Z | 2010 | Przegl Epidemiol2010，64，： | 1 |
| 17 | 3-D fluid-mud dynamics in the Jiaojiang Estuary, China显示文摘 | Guan W B Kot S C Wolanski E | 2005 | Estuarine Coastal and Shelf Science2005，65，4： | 1 |
| 18 | Fundamentals of dual phase stecls显示文摘 | Kot R A Bramfitt L B | 1981 | Processing of TMS-AIME1981，，： | 1 |
| 19 | Alternate surface measurements for GMT primary mirror segments 显示文摘 | Burge J H Kot L B Martin H M | 2006 | SPIE2006，6273，62： | 1 |
| 20 | Antimicrobial resist- ance and genotypes of staphylococci from bovine milk and the cow- shed environment 显示文摘 | Kot B Pieehota M Antos-Bielska M | 2013 | Polish Journal of Veterinary Sciences2013，15，4： | 1 |
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