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| 1 | Feasibility of single-incision laparoscopic cholecystectomy for acute cholecystitis显示文摘AIM: To assess the safety of single-incision laparoscopic cholecystectomy(SILC) for acute cholecystitis.METHODS: All patients who underwent SILC at Sano Hospital(Kobe, Japan) between January 2010 and December 2014 were included in this retrospective study. Clinical data related to patient characteristics and surgical outcomes were collected from medical records. The parameters for assessing the safety of the procedure included operative time, volume of blood loss, achievement of the critical view of safety, use of additional trocars, conversion to laparotomy, intraoperative and postoperative complications, and duration of postoperative hospital stay. Patient backgrounds were statistically compared between those with and without conversion to laparotomy.RESULTS: A total of 100 patients underwent SILC for acute cholecystitis during the period. Preoperative endoscopic treatment was performed for suspected choledocholithiasis in 41 patients(41%). The mean time from onset of acute cholecystitis was 7.7 d. According to the Updated Tokyo Guidelines(TG13) for the severity of cholecystitis, 86 and 14 patients had grade Ⅰ and grade Ⅱ acute cholecystitis, respectively. The mean operative time was 87.4 min. The mean estimated blood loss was 80.6 mL. The critical view of safety was obtained in 89 patients(89%). Conversion laparotomy was performed in 12 patients(12%). Postoperative complications of Clavien-Dindo grade Ⅲ or greater were observed in 4 patients(4%). The mean duration of postoperative hospital stay was 5.7 d. Patients converted from SILC to laparotomy tended to have higher days after onset.CONCLUSION: SILC is feasible for acute cholecystitis; in addition, early surgical intervention may reduce the risk of laparotomy conversion. | Taro Ikumoto Hidetsugu Yamagishi Mineo Iwatate Yasushi Sano Masahito Kotaka Yasuo Imai | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，19： | 8 |
| 2 | Narrow-band imaging observation of colorectal lesions using NICE classification to avoid discarding significant lesions显示文摘AIM: To assess the risk of failing to detect diminutive and small colorectal cancers with the 'resect and discard' policy.METHODS: Patients who received colonoscopy and polypectomy were recruited in the retrospective study. Probable histology of the polyps was predicted by six colonoscopists by the use of NICE classification. The incidence of diminutive and small colorectal cancersand their endoscopic features were assessed. RESULTS: In total, we found 681 cases of diminutive(1-5 mm) lesions in 402 patients and 197 cases of small(6-9 mm) lesions in 151 patients. Based on pathology of the diminutive and small polyps, 105 and 18 were non-neoplastic polyps, 557 and 154 were low-grade adenomas, 18 and 24 were high-grade adenomas or intramucosal/submucosal(SM) scanty invasive carcinomas, 1 and 1 were SM deeply invasive carcinoma, respectively. The endoscopic features of invasive cancer were classified as NICE type 3 endoscopically.CONCLUSION: The risk of failing to detect diminutive and small colorectal invasive cancer with the 'resect and discard' strategy might be avoided through the use of narrow-band imaging observation with the NICE classification scheme and magnifying endoscopy. | Santa Hattori Mineo Iwatate Wataru Sano Noriaki Hasuike Hidekazu Kosaka Taro Ikumoto Masahito Kotaka Akihiro Ichiyanagi Chikara Ebisutani Yasuko Hisano Takahiro Fujimori Yasushi Sano | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，12： | 5 |
| 3 | Study protocol of the Asian XELIRI ProjecT(AXEPT):a multinational,randomized,non-inferiority,phase Ⅲ trial of second-line chemotherapy for metastatic colorectal cancer, comparing the eicacy and safety of XELIRI with or without bevacizumab versus FOLFIRI w显示文摘Background: Capecitabine and irinotecan combination therapy(XELIRI) has been examined at various dose levels to treat metastatic colorectal cancer(m CRC). Recently, in the Association of Medical Oncology of the German Cancer Society(AIO) 0604 trial, tri?weekly XELIRI plus bevacizumab, with reduced doses of irinotecan(200 mg/m^2 on day 1) and capecitabine(1600 mg/m^2 on days 1–14), repeated every 3 weeks, has shown favorable tolerability and eicacy which were comparable to those of capecitabine and oxaliplatin(XELOX) plus bevacizumab. The doses of capecit?abine and irinotecan in the AIO trial are considered optimal. In a phase I/II study, XELIRI plus bevacizumab(BIX) as second?line chemotherapy was well tolerated and had promising eicacy in Japanese patients.Methods: The Asian XELIRI Projec T(AXEPT) is an East Asian collaborative, open?labelled, randomized, phase Ⅲ clinical trial which was designed to demonstrate the non?inferiority of XELIRI with or without bevacizumab versus standard FOLFIRI(5?fluorouracil, leucovorin, and irinotecan combination) with or without bevacizumab as second?line chemo?therapy for patients with m CRC. Patients with 20 years of age or older, histologically conirmed m CRC, Eastern Coop?erative Oncology Group performance status 0–2, adequate organ function, and disease progression or intolerance of the irst?line regimen will be eligible. Patients will be randomized(1:1) to receive standard FOLFIRI with or with?out bevacizumab(5 mg/kg on day 1), repeated every 2 weeks(FOLIRI arm) or XELIRI with or without bevacizumab(7.5 mg/kg on day 1), repeated every 3 weeks(XELIRI arm). A total of 464 events were estimated as necessary to show non?inferiority with a power of 80% at a one?sided α of 0.025, requiring a target sample size of 600 patients. The 95% conidence interval(CI) upper limit of the hazard ratio was pre?speciied as less than 1.3.Conclusion: The Asian XELIRI Projec T is a multinational phase III trial being conducted to provide evidence for XELIRI with or without bevacizumab as a second?line treatment option of mCRC. | Masahito Kotaka Ruihua Xu Kei Muro Young Suk Park Satoshi Morita Satoru Iwasa Hiroyuki Uetake Tomohiro Nishina Hiroaki Nozawa Hiroshi Matsumoto Kentaro Yamazaki Sae-Won Han Wei Wang Joong Bae Ahn Yanhong Deng Sang-Hee Cho Yi Ba Keun-Wook Lee Tao Zhang Taroh Satoh Marc E.Buyse Baek-Yeol Ryoo Lin Shen Junichi Sakamoto Tae Won Kim | 2016 | Chinese Journal of Cancer2016，35，12： | 3 |
| 4 | Synthesis and Structure of Smectic Clay/poly(methyl methacrylate) and Clay/polystyrene Nanocomposites via in Situ Interalative Polymerization显示文摘 | Masami Okamoto Satoshi Morita Hideyuki Taguchi Yong Hoon Kim Tadao Kotaka Hiroshi Tateyama | 2000 | Polymer2000，，41： | 1 |
| 5 | Block Copolymer Micelles in Dilute Solution显示文摘 | Kotaka T Tanaka T Hattori M | 1978 | Macromolecules1978，11，1： | 1 |
| 6 | Old yellow enzyme from Candida mace- doniensis catalyzes the stereospecific reduction of the C=C bond of ketoisophorone显示文摘 | Kataoka M kotaka A | 2002 | Bioscience Biotechnology Biocheistry2002，66，12： | 1 |
| 7 | Rapid decontamination of gutta-percha cones with sodium hypochlorite显示文摘 | Cardoso CL Kotaka CR Redmerski R | 1999 | J Endod1999，25，7： | 1 |
| 8 | Fundamental studies on the ion-exchange separation of boron isotopes显示文摘 | Kakihana H Kotaka M Satoh S | 1977 | Bulletinof the Chemical Society of Japan1977，50，1： | 1 |
| 9 | Biaxial flow-induced alignment of silicate layers in polypropylene/clay nanocomposite foam 显示文摘 | Okamoto M Nam P H Maiti P Kotaka T | 2001 | Nano Letters2001，9，1： | 1 |
| 10 | Translecation of a human focal adhesion LIM-only protein,FHL2,during myofibrillogenesis and identification of LIM2 as the principal determinants of FHL2 focal adhesion localization显示文摘 | LI H Y KOTAKA M KOSTIN S | 2001 | Cell Motil Cytaskeleton2001，48，1： | 1 |
| 11 | Viscoplastic Material Modeling for the Stretch Blow Molding Simulation 显示文摘 | SWang A Makinouchi M Okamoto T Kotaka M Maeshima N Ibe T Nakagawa | 2000 | Intern Polym Proc2000，15，2： | 1 |
| 12 | 显示文摘 | Nishi S Kotaka T | 1989 | Polym1989，21，： | 1 |
| 13 | Isoflavone aglyconesproduction from isoflavone glycosides by display of b-glucosidase from Aspergillus oryzae on yeast cellsurface 显示文摘 | Kaya M Ito J Kotaka A | 2008 | Applied Microbiology and Biotechnology2008，79，1： | 1 |
| 14 | Early results of intersphincteric resection for patients with very low rectal cancer: An active approach to avoid a permanent colostomy显示文摘 | Norio Saito Masato Ono Masanori Sugito Masaaki Ito Masato Morihiro Chihiro Kosugi Kazunori Sato Masahito Kotaka Satoru Nomura Manabu Arai Takaya Kobatake | 2004 | Diseases of the Colon & Rectum2004，，4： | 1 |
| 15 | Dispersed structure and ionic conductivity of smectic clay/polymer nanocomposites 显示文摘 | Okato M Morita S Kotaka T | 2001 | Polymer2001，42，6： | 1 |
| 16 | Structures of S aureus thymidylate kinase reveal an atypical active site configuration and an intermediate conformational state upon sub strate binding显示文摘 | KOTAKA M DHALIWAL B REN J | 2006 | Protein Sci2006，15，4： | 1 |
| 17 | Phase separation and homogenization in poly ( ethylene naphthalene-2, 6-dicarboxylate )/poly ( ethylene terephthalate) blends显示文摘 | OKAMOTO M KOTAKA T | 1997 | Polymer1997，38，6： | 1 |
| 18 | Isoflavone aglycones production from isoflavone glycosides by display of β-glucosidase from Aspergillus oryzae on yeast cell surface显示文摘 | KAYA M ITO J KOTAKA A | 2008 | Appl Microbiol Biotechnol2008，79，： | 1 |
| 19 | Fundamental studies on the ion-exchange separation of boron isotopes显示文摘 | KAKIHANA H KOTAKA M SATOH S | 1977 | Bulletin of Chemical Society in Japan1977，50，： | 1 |
| 20 | Early results of intersphincteric resection for patients with very low rectal cancer: An active approach to avoid a permanent colostomy显示文摘 | Norio Saito Masato Ono Masanori Sugito Masaaki Ito Masato Morihiro Chihiro Kosugi Kazunori Sato Masahito Kotaka Satoru Nomura Manabu Arai Takaya Kobatake | 2004 | Diseases of the Colon & Rectum2004，，4： | 1 |
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