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| 1 | Levels of matrix metalloproteinase-1 and tissue inhibitors of metalloproteinase-1 in gastric cancer显示文摘AIM:To evaluate the levels of preoperative serum matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in gastric cancer.METHODS:One hundred gastric cancer patients who underwent gastrectomy were enrolled in this study.The serum concentrations of MMP-1 and TIMP-1 in these patients and in fifty healthy controls were determined using an enzyme-linked immunosorbent assay.RESULTS:Higher serum MMP-1 and TIMP-1 levels were observed in patients than in controls (P < 0.001).Serum MMP-1 and TIMP-1 levels were positively associated with morphological appearance,tumor size,depth of wall invasion,lymph node metastasis,liver metastasis,perineural invasion,and pathological stage.They were not significantly associated with age,gender,tumor location,or histological type.CONCLUSION:Increased MMP-1 and TIMP-1 were associated with gastric cancer.Although these markers are not good markers for diagnosis,these markers show in advanced gastric cancer. | Ozgur Kemik Ahu Sarbay Kemik Aziz Sümer Ahmet Cumhur Dulger Mine Adas Huseyin Begenik Ismail Hasirci Ozkan Yilmaz Sevim Purisa Erol Kisli Sefa Tuzun Cetin Kotan | 2011 | World Journal of Gastroenterology2011，17，16： | 10 |
| 2 | Inactivating KISS1 mutation and hypogonadotropic hypogonadism 显示文摘 | Topaloglu AK Tello JA Kotan LD | 2012 | N Engl J Med2012，366，7： | 1 |
| 3 | Biological control of the potato dry rot caused by Fusarium species using PGPR strains 显示文摘 | KOTAN R FIKRETTIN S ERKOL D | 2009 | Biol Control2009，50，2： | 1 |
| 4 | Treatment of recurrent perforating intestinal ulcers with thalidomide in Behcet's disease显示文摘 | Sayarlioglu M Kotan MC Topcu N | 2004 | Ann Pharmacother2004，38，5： | 1 |
| 5 | An analysis of 13 patients with perforated gastric carcinoma:A surgeon's nightmare显示文摘 | Sumer A | 2008 | World J Emerg Surg2008，3，1： | 1 |
| 6 | Serum brain-derived neurotrophic factor, vascular endothelial growth factor and leptin levels in pa- tients with a diagnosis of severe major depressive disorder with melancholic features显示文摘 | Kotan Sarandol Kirhan | 2012 | Ther Adv Psychopharmacol2012，2，2： | 1 |
| 7 | Coexistent thyroid pathologies and high rate of papillary cancer in patients with primary hyperparathyroidism: controversies about minimal invasive parathyroid surgery显示文摘 | Kosem M Algun E Kotan C | 2004 | Acta Chir Belg2004，104，5： | 1 |
| 8 | Determination of honokiol and magnolol bymicro HPLC with electrochemical detec tion and its application to the distribution analysis in branches and leaves of magnolia obovata 显示文摘 | Kotan IA Kojima S Hakamata H | 2005 | Chem Pharm Bull2005，53，3： | 1 |
| 9 | Outcome of surgical treatment of intestinal perforation in typhoid fever显示文摘AIM:To represent our clinical experience in the treatment of intestinal perforation arising from typhoid fever.METHODS:The records of 22 surgically-treated patients with typhoid intestinal perforation were evaluated retrospectively.RESULTS:There were 18 males and 4 females,mean age 37 years(range,8-64 years).Presenting symptoms were fever,abdominal pain,diarrhea or constipation.Sixteen cases were subjected to segmental resection and end-to-end anastomosis,while 3 cases received 2-layered primary repair following debridement,one case with multiple perforations received 2-layered primary repair and end ileostomy,one case received segmental resection and end-to-end anastomosis followed by an end ileostomy,and one case received segmental resection and end ileostomy with mucous fistula operation.Postoperative morbidity was seen in 5 cases and mortality was found in one case.CONCLUSION:Intestinal perforation resulting from Salmonella typhi is an important health problem in Eastern and Southeastern Turkey.In management of this illness,early and appropriate surgical intervention is vital. | Aziz Sümer zgür Kemik Ahmet Cumhur Dülger Aydemir Olmez Ismail Hasirci Erol Kisli Vedat Bayrak Gulay Bulut etin Kotan | 2010 | World Journal of Gastroenterology2010，16，33： | 1 |
| 10 | An analysis of 13 patients with perforated gastric carcinoma: A surgeon's nightmare显示文摘 | Kotan C Sumer A Baser M | 2008 | World J Emerg Surg2008，3，1： | 1 |
| 11 | Coexistent thyroid pathologies and high rate of papillary cancer in patients with primary hyperparathyroidism:controversies about minimal invasive parathyroid surgery显示文摘 | Kosem M Algün E Kotan C | 2004 | Acta Chir Belg2004，104，5： | 1 |
| 12 | Yogurt enriched with Lactobacillus acidophilus doesn't lower blood lipids in healthy men and women with normal to borderline high serum cholesterol levels显示文摘 | Schouten G Kotane M B | 1998 | EurJ Clin Nutr1998，53，： | 1 |
| 13 | Micro - Theological chan-ges during experimental acute pancreatitis in the rat 显示文摘 | KOTAN R NEMETH N KISS F | 2012 | ClinHemorheot Microcirc2012，51，4： | 1 |
| 14 | Significance of VEGF and microvascular density in gastric carcinoma 显示文摘 | Kosem M Tuncer I Kotan C | 2009 | Heloatogastroenterology2009，56，93： | 1 |
| 15 | Inactivating KISS1 muta- tion and hypogonadotropic hypogonadism 显示文摘 | Topaloglu AK Tello JA Kotan LD | 2012 | N Engl J Med2012，366，7： | 1 |
| 16 | Antibacterial activities of essential oils and extracts of Turkish Achillea, Satureja and Thymus species against plant pathogenic bacteria显示文摘 | Kotan R Cakir A Dadasoglu F | 2010 | Journal of the Science of Food and Agriculture2010，90，1： | 1 |
| 17 | Inactivating KISS1 mutation and hypogonadotropic hypogonadism显示文摘 | Topaloglu AK Tello JA Kotan LD | 2012 | N Engl J Med2012，366，7： | 1 |
| 18 | Micro-rheological changes during experimental acute pancreatitis in the rat显示文摘 | KOTAN R NEMETH N KISS F | 2012 | Clinical Hemorheology and Microcirculation2012，51，4： | 1 |
| 19 | Primary Malignant Fibrous Histiocytoma of the Small Intestine Presenting as an Intussusception: Report of a Case显示文摘 | Cetin Kotan Mustafa Kosem Süleyman Alici Mahmut Ilhan Ilyas Tuncer Mustafa Harman | 2002 | Surgery Today2002，，12： | 1 |
| 20 | Evaluation of antimicrobial activities of Satureja hortensis L.显示文摘 | F ?ahin ? Karaman M Güllüce H ??üt?ü M ?engül A Ad?güzel S ?ztürk R Kotan | 2003 | Journal of Ethnopharmacology2003，，1： | 1 |
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