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| 1 | Liver cirrhosis induced by long-term administration of a daily low dose of amiodarone: A case report显示文摘The anti-arrhythmic agent amiodarone (AD) is associated with numerous adverse effects, but serious liver disease is rare. The improved safety of administration of daily low doses of AD has already been established and this regimen is used for long-term medication. Nevertheless,asymptomatic continuous liver injury by AD may increase the risk of step-wise progression of non-alcoholic fatty liver disease. We present an autopsy case of AD-induced liver cirrhosis in a patient who had been treated with a low dose of AD (200 mg/d) daily for 84 mo. The patient was a 85-year-old male with a history of ischemic heart disease.Seven years after initiation of treatment with AD, he was admitted with cardiac congestion. The total dose of AD was 528 g. Mild elevation of serum aminotransferase and hepatomegaly were present. Liver biopsy specimens revealed cirrhosis, and under electron microscopy numerous lysosomes with electron-dense, whorled, lamellar inclusions characteristic of a secondary phospholipidosis were observed. Initially, withdrawal of AD led to a slight improvement of serum aminotransferase levels, but unfortunately his general condition deteriorated and he died from complications of pneumonia and renal failure.Long-term administration of daily low doses of AD carries the risk of progression to irreversible liver injury. Therefore,periodic examination of liver function and/or liver biopsy is required for the management of patients receiving long-term treatment with AD. | Hiroki Oikawa Chihaya Maesawa Ryo Sato Kanta Oikawa Hiroyuki Yamada Seizo Oriso Sadahide Ono Akiko Yashima-Abo Koji Kotani Kazuyuki Suzuki Tomoyuki Masuda | 2005 | World Journal of Gastroenterology2005，11，34： | 4 |
| 2 | Mechanisms and anatomical risk factors of pneumothorax after Bevacizumab use:A case report显示文摘BACKGROUND Bevacizumab is an antiangiogenic agent,and that synergizes with chemotherapeutic drugs.When used in combination therapies,Bevacizumab is associated with adverse events such as hemorrhage,gastrointestinal perforation,delayed wound healing,and pneumothorax.However,the molecular mechanisms underlying these adverse events are not fully understood.CASE SUMMARY A 45-year-old female with multiple lung metastases that were derived from primary breast cancer,was placed on Bevacizumab+paclitaxel therapy,since this combination has a potent antitumor effect.She reported dyspnea before cycle 3,day 1 and we therefore ran a chest X-ray,which detected a right pneumothorax.The coronal plane computed tomography revealed that one solid mass rapidly necrosed and was replaced by a cavity that passed through the bronchus in the right lower lobe.The cavity eventually ruptured the pleura and made the bronchopleural fistula that led to this pneumothorax.Thoracic cavity drainage using an intercostal catheter was performed.On the 7th day of drainage,the patient was discharged from our hospital on recovery.Recurrence of pneumothorax was not reported,and continuation of chemotherapy was made possible by changing the regimen.CONCLUSION Patients with lung metastases surrounding the bronchi and on the pleura should be monitored for pneumothorax by Bevacizumab-containing chemotherapies. | Yuri Ozaki Akiyo Yoshimura Masataka Sawaki Masaya Hattori Naomi Gondo Haruru Kotani Yayoi Adachi Ayumi Kataoka Kayoko Sugino Nanae Horisawa Yuka Endo Kazuki Nozawa Shoko Sakamoto Hiroji Iwata | 2020 | World Journal of Clinical Oncology2020，11，7： | 2 |
| 3 | A metabolomic approach to lung cancer显示文摘 | Suya Hori Shin Nishiumi Kazuyuki Kobayashi Masakazu Shinohara Yukihisa Hatakeyama Yoshikazu Kotani Naoya Hatano Yoshimasa Maniwa Wataru Nishio Takeshi Bamba Eiichiro Fukusaki Takeshi Azuma Tadaomi Takenawa Yoshihiro Nishimura Masaru Yoshida | 2011 | Lung Cancer2011，，2： | 2 |
| 4 | Objective picture quality scale for image coding显示文摘 | MIYAHARA M KOTANI K ALGAZI V R | 1998 | IEEE Trans Comm1998，46，9： | 1 |
| 5 | Improved accuracy of computer --asssisted cervical pediele screw insertion显示文摘 | Kotani Y Abumi K ho M | 2003 | J Neurosurg2003，99，3： | 1 |
| 6 | Lens formation in the absence of optic cup in rat embryos irradiated with soft X-ray显示文摘 | Inagaki S Kotani T | 2003 | Vet Ophthalmol2003，6，1： | 1 |
| 7 | Volatile anesthetics augment expression of proinflammatory cytokines in rat alveolar macrophages during mechanical ventilation显示文摘 | Kotani N Takahashi S Sessler DI | 1999 | Anesthesiology1999，91，： | 1 |
| 8 | Enteral nutrition prevents bacterial translocation but does not improve survival during acute pancreatitis显示文摘 | Kotani J Usami M Nomura H | 1999 | Arch Surg1999，134，： | 1 |
| 9 | Production of ubiquinone - 10 using bacteria显示文摘 | Yoshida H Kotani Y Ochiai K Araki K | 1998 | Journal of General and Applied Microbiology1998，44，1： | 1 |
| 10 | CD28-dependent differentiation into the effector/memory phenotype is essential for induction of arthritis ininterleukin-1 receptor antagonist-deficient mice显示文摘 | Kotani M Hirata K Ogawa S | 2006 | Arthritis Rheum2006，54，2： | 1 |
| 11 | Fasudil, a Rho kinase (ROCK) inhibitor, protects against ischemic neuronal damage in vitro and in vivo by acting directly on neurons显示文摘 | Yamashita K Kotani Y Nakajima Y | 2007 | Brain Res2007，1154，： | 1 |
| 12 | Themetastasis suppressor gene Kiss-1 encodes kisspeptins,the naturalligands of the orphan G protein-coupled receptor GPR54 显示文摘 | KOTANI M DETHEUX M VANDENBOGAERDE A | 2001 | J BiolChem2001，276，34： | 1 |
| 13 | A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling显示文摘 | Iwai H Kim M Yoshikawa Y Ashida H Ogawa M Fujita Y Muller D Kirikae T Jackson PK Kotani S | 2007 | Cell2007，130，4： | 1 |
| 14 | Expression of free fatty acid receptor GPR40 in the central nervous system of adult monkeys显示文摘 | Ma D Tao B Warashina S Kotani S Lu L Kaplamadzhiev DB Mori Y Tonchev AB Yamashima T | | 0，，04： | 1 |
| 15 | The rol of anteromedial hraminotomy and the uncovertebral joints in the stability of the cervical spine a biomechanical study 显示文摘 | Kotani Y MeNulty PS AburQi K et ai | 1998 | Spine1998，23，： | 1 |
| 16 | Dominant negative forms of Akt (protein kinase B) and atypical protein kinase Ca do not prevent insulin inhibition of phosphoenolpyruvate carboxyki nase gene transcription 显示文摘 | Kotani K Ogaw a W HinoY | 1999 | J Biol Chem1999，274，21： | 1 |
| 17 | The metastasis suppressor gene KISS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54显示文摘 | Kotani M Detheux M Vandenbogaerde A | 2001 | J BiolChem2001，276，34： | 1 |
| 18 | Fasudil,a Rho kinase (ROCK) inhibitor,protects against ischemic neuronal damage in vitro and in vivo by acting directly on neurons显示文摘 | Yamashita K Kotani Y Nakajima Y | 2007 | Brain Res2007，1154，： | 1 |
| 19 | Amchidonic acid preserves hippocampal neuron membrane fluidity in senescent rats显示文摘 | Fukaya T Gondaira T Kashiyae Y Kotani S Ishikum Y Fujikawa S | 2007 | Neurobiology of aging2007，28，： | 1 |
| 20 | Plaque gruel of atheromatous coronary lesion may contribute to the no-reflow phenomenon in patients with acute coronary syndrome显示文摘 | Kotani J Nanto S Mintz GS | 2002 | Circulation2002，106，13： | 1 |
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