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| 1 | Hidden risks associated with conventional short intermittent hemodialysis:A call for action to mitigate cardiovascular risk and morbidity显示文摘The development of maintenance hemodialysis(HD)for end stage kidney disease patients is a success story that continues to save many lives.Nevertheless,intermittent renal replacement therapy is also a source of recurrent stress for patients.Conventional thrice weekly short HD is an imperfect treatment that only partially corrects uremic abnormalities,increases cardiovascular risk,and exacerbates disease burden.Altering cycles of fluid loading associated with cardiac stretching(interdialytic phase)and then fluid unloading(intradialytic phase)likely contribute to cardiac and vascular damage.This unphysiologic treatment profile combined with cyclic disturbances including osmotic and electrolytic shifts may contribute to morbidity in dialysis patients and augment the health burdenof treatment. As such, HD patients are exposed to multiple stressors including cardiocirculatory,inflammatory, biologic, hypoxemic, and nutritional. This cascade of events can be termed thedialysis stress storm and sickness syndrome. Mitigating cardiovascular risk and morbidityassociated with conventional intermittent HD appears to be a priority for improving patientexperience and reducing disease burden. In this in-depth review, we summarize the hidden effectsof intermittent HD therapy, and call for action to improve delivered HD and develop treatmentschedules that are better tolerated and associated with fewer adverse effects. | Bernard Canaud Jeroen P Kooman Nicholas M Selby Maarten Taal Andreas Maierhofer Pascal Kopperschmidt Susan Francis Allan Collins Peter Kotanko | 2022 | World Journal of Nephrology2022，11，2： | 2 |
| 2 | Upregulation of ' operativeα2/β2 adrenoceptor ratio' by high salt diet predicts blood press ure response in salt sensitive subjects显示文摘 | Kotanko P Meister B | 1987 | J Cardrovase Pharmacol1987，10，4： | 1 |
| 3 | Postrenal transplant erythrocytosis:a possible role for testosterone,angiotension I coverting enzyme,and N-acetyl-aspartyl-lysyl-proline显示文摘 | Kotanko U | 1996 | Clin Nephrol1996，46，3： | 1 |
| 4 | Current state of bioinped-ance technologies in dialysis 显示文摘 | Kotanko P Levin NW Zhu F | 2008 | Nephrol Dial Trans-plant2008，23，： | 1 |
| 5 | Minireview:inverse re-gulatio n of α2 and β2 adrenoceptors in salt-sensitive hypertension:an hypothesis 显示文摘 | Kotanko P Luft FC | 1989 | Life Sci1989，45，： | 1 |
| 6 | HospiLal- ization and mortality in hemodialysis patients: associ- ation with hemoglobin variability显示文摘 | Handelman GJ Kotanko P Cisternas MG | 2013 | Blood Purif2013，35，4： | 1 |
| 7 | Essential hypertension in african caribbeans associates with a variant of the β2 adrenoceptor显示文摘 | Binder A Tasker J | 1997 | Hypertension1997，30，： | 1 |
| 8 | Essential Hypertension in African caribbeans associates with a variant of the β2-adrenoceptor显示文摘 | Kotanko P Binder A Tasker J | 1997 | Hypertension1997，30，4： | 1 |
| 9 | International differ- ences in dialysis mortality reflect background general population atherosclerotic cardiovascular mortality显示文摘 | Yoshino M Kuhlmann M K Kotanko P | 2006 | J Am Soc Nephrol2006，17，12： | 1 |
| 10 | Clinical bene-fit of preserving residual renal function in dialysispatients: an update for clinicians 显示文摘 | Brener ZZ Kotanko P Thijssen S | 2010 | Am J Med Sci2010，339，： | 1 |
| 11 | Prevalence and characterization of renal tubular acidosis in patients with osteopenia and osteporosis and in non-porotic controls显示文摘 | Weger W Kotanko P Weger M et ai | 2000 | Nephrol Dial Transpiant2000，15，7： | 1 |
| 12 | Blood pressure in chronic kidney disease stage 5D-report from a kidney disease:improving global outcomes controversies conference显示文摘 | Levin NM Kotanko P Eckardt KU | 2010 | Kidney Int2010，77，4： | 1 |
| 13 | Metabolic con sequences of body size and body composition in hemodi alysis patients显示文摘 | Sarkar SR Kuhlmann MK Kotanko P | 2006 | Kidney Int2006，70，18： | 1 |
| 14 | Intensive hemodialysis in the(nursing)home:the bright side of geriatric ESRD care?显示文摘 | Cornelis T Kotanko P Goffin E | 2012 | Semin Dial2012，25，6： | 1 |
| 15 | Absolute blood volume in hemodialysis patients:why is it relevant,and how to mea- sure it?显示文摘 | Thijssen S Kappel F Kotanko P | 2013 | Blood Purif2013，35，13： | 1 |
| 16 | Essential hypertension in African Caribbeans associate with a variant of the beta-2 adrenoceptor显示文摘 | Kotanko P Binder A Tasker J | 1997 | Hypertension1997，30，4： | 1 |
| 17 | The KDIGO guideline for dialysate calcium will result in an in- creased incidence of calcium accumulationin hemodialy- sis patients 显示文摘 | Gotch PA Kotanko P Thijssen S | 2010 | Kidneylnternational2010，78，： | 1 |
| 18 | Rhabdomyolysis and acute re- nal graft impairment in a patient treated with simvastatin, tacrolimus and fusidic Acid显示文摘 | Kotanko P KJrisits W Skrabel F | 2002 | Nephron2002，90，2： | 1 |
| 19 | Clinical Benefit of Preserving Residual Renal Function in Dialysis Patients: An Update for Clinicians显示文摘 | Zachary Z. Brener Peter Kotanko Stephan Thijssen James F. Winchester Michael Bergman | 2010 | The American Journal of the Medical Sciences2010，，5： | 1 |
| 20 | Clinical benefit of preserving residual renal function in dialysis Patients: An up- date for clinicians显示文摘 | BRENER ZZ KOTANKO P THIJSSEN S | 2010 | The American Journal of the Medical Sci-enees2010，399，5： | 1 |
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