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| 1 | Contribution of epigenetics in diabetic retinopathy显示文摘Diabetes has become the epidemic of the 21 st century, and with over 90% patients with diabetes becoming at a risk of developing retinopathy, diabetic retinopathy has emerged as a major public health concern. In spite of cutting edge research in the field, how retina and its vasculature are damaged by the diabetic milieu remains ambiguous. The environmental factors, life style or disease process can also bring in modifications in the DNA, and these epigenetic modifications either silence or activate a gene without altering the DNA sequence. Diabetic environment up- or downregulates a number of genes in the retina, and emerging research has shown that it also facilitates epigenetic modifications. In the pathogenesis of diabetic retinopathy, the genes associated with important enzymes(e.g., mitochondrial superoxide dismutase, matrix metalloproteinase-9 and thioredoxin interacting protein) and transcriptional factors are epigenetically modified, the enzymes responsible for these epigenetic modifications are either activated or inhibited, and the levels of micro RNAs are altered. With epigenetic modifications taking an important place in diabetic retinopathy, it is now becoming critical to evaluate these modifications, and understand their impact on this slow progressing blinding disease. | KOWLURU Renu A. MISHRA Manish | 2015 | Science China(Life Sciences)2015，58，6： | 12 |
| 2 | Evidence for differential roles of the Rho subfamily of GTP-binding proteins in glucose- and calcium-induced insulin secretion from pancreatic beta cells显示文摘 | Kowluru A Li G Rabaglia ME | 1997 | Biochem Pharmacol1997，54，10： | 1 |
| 3 | Epigenetic changes in mitochondrial superoxide dismutase in the retina and the development of diabetic retinopathy显示文摘 | Zhong Q and Kowluru RA | 2011 | Diabetes2011，60，4： | 1 |
| 4 | Diabetic retinopathy:mitochondrial dysfunction and retinal capillary cell death显示文摘 | Kowluru RA | | 0，，： | 1 |
| 5 | Oxidative stress and diabetic retinopathy显示文摘 | Kowluru R A Chan P S | | 0，，： | 1 |
| 6 | Role of mitochondrial dna damage in the development of diabetic retinopathy, and the metabolic memory phenomenon associated with its progression 显示文摘 | MADSEN-BOUTERSE SA MOHAMMAD G KANWAR M KOWLURU RA | 2010 | Antioxid Redox Signal2010，13，6： | 1 |
| 7 | A farnesylated G - protein suppresses Akt phosphorylation in INS 832/13 cells and normal rat islets: regulation by pertussis toxin and PGE 显示文摘 | INS KYATHANAHALLI C N KOWLURU A | 2011 | Bio- chem Pharmacol2011，81，10： | 1 |
| 8 | Friendly, and not so friendly, roles of Rac1 in islet β-cell function: Lessons learnt from pharmacological and molecular biological approaches显示文摘 | Anjaneyulu Kowluru | 2011 | Biochemical Pharmacology2011，，8： | 1 |
| 9 | Effect of advanced glycation end products onaccelerated apoptosis of retinal capillary cells under in vitroconditions显示文摘 | Kowluru RA | 2005 | Life Sci2005，76，9： | 1 |
| 10 | Epigenetic modification of Sod2 in the development of diabetic retinopathy and in the metabolic memory: role of histone methylation 显示文摘 | Zhong Q Kowluru RA | 2013 | Invest Ophthalmol Vis Sci2013，54，1： | 1 |
| 11 | Metabolic memory phenomenon and accumulation of peroxynitrite in retinal capillaries显示文摘 | Kowluru RA Kanwar M Kennedy A | 2007 | Exp Diabetes Res2007，2007，： | 1 |
| 12 | Role of matrix metalloproteinase - 9 in the development of diabetic retinopathy and its regulation by H - ras 显示文摘 | Kowluru RA | 2010 | Invest Ophthalmol Vis Sci2010，51，8： | 1 |
| 13 | Epigenetic changes in mitochondrial superoxide dismutase in the retina and the development of diabetic retinopathy显示文摘 | Zhong Q Kowluru RA | 2011 | Diabetes2011，60，4： | 1 |
| 14 | Regulation of matrix metalloproteinase-9 by epigenetic modifications and the development of diabetic retinopathy显示文摘 | Zhong Q Kowluru RA | 2013 | Diabetes2013，62，7： | 1 |
| 15 | Metabolic memory in diabetes-from in vitro oddity to in vivo problem: role of apoptosis 显示文摘 | Kowluru RA Chan PS | 2010 | Brain Res Bull2010，81，23： | 1 |
| 16 | Resistance of retinal inflammatory mediators to suppress after reinstitution of good glycemic control:novel mechanism for metabolic memory显示文摘 | Chan PS Kanwar M Kowluru RA | | 0，，： | 1 |
| 17 | Ceramide induces mitochondrial abnormalities in insulin-secreting INS-1 cells: Potential mechanisms underlying ceramide-mediated metabolic dysfunction of the β cell显示文摘 | R. Veluthakal R. Palanivel Y. Zhao P. McDonald S. Gruber A. Kowluru | 2005 | Apoptosis2005，，4： | 1 |
| 18 | Regulation of matrix metalloproteinase- 9 by epigenetic modifications and the development of diabetic retinopathy 显示文摘 | Zhong Q Kowluru RA | 2013 | Diabetes2013，62，7： | 1 |
| 19 | Oxidative stress and diabetic retinopathy显示文摘 | Kowluru RA Chan PS | 2007 | Exp Diabetes Res2007，，43： | 1 |
| 20 | Role of histone acetylation in the development of diabetic retinopathy and the metabolic memory phenomenon显示文摘 | Zhong Q Kowluru RA | | 0，，： | 1 |
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