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| 1 | Vildagliptin-insulin combination improves glycemic control in Asians with type 2 diabetes显示文摘AIM: To assess the efficacy and safety of vildagliptin 50 mg bid as add-on therapy to insulin in Asian patients with type 2 diabetes mellitus(T2DM).METHODS: This was a post hoc analysis of a subgroup of Asian patients from a multicenter,randomized,double-blind,placebo-controlled,parallel-group study in T2DM patients inadequately controlled by stable insulin therapy,with or without metformin.A total of 173 patients were randomized 1:1 to receive treatment with vildagliptin 50 mg bid(n = 87) or placebo(n = 86) for 24 wk.Changes in HbA1c and fasting plasma glucose(FPG),from baseline to study endpoint,were analyzed using an analysis of covariance model.Change from baseline to endpoint in body weight was summarized by treatment.Safety and tolerability of vildagliptin was also evaluated.RESULTS: After 24 wk,the difference in adjusted mean change in HbA1c between vildagliptin and placebo was 0.82%(8.96 mmol/mol;P < 0.001) in Asian subgroup,0.85%(9.29 mmol/mol;P < 0.001) in patients also receiving metformin,and 0.73%(7.98 mmol/mol;P < 0.001) in patients without metformin,all in favor of vildagliptin.There was no significant difference in the change in FPG between treatments.Weight was stable in both treatment groups(+0.3 kg and-0.2 kg,for vildagliptin and placebo,respectively).Overall,vildagliptin was safe and well tolerated with similarly low incidences of hypoglycemia(8.0% vs 8.1%) and no severe hypoglycemic events were experienced in either group.CONCLUSION: In Asian patients inadequately controlled with insulin(with or without concomitant metformin),insulin-vildagliptin combination treatment significantly reduced HbA1c compared with placebo,without an increase in risk of hypoglycemia or weight gain. | Plamen Kozlovski James Foley Qing Shao Valentina Lukashevich Wolfgang Kothny | 2013 | World Journal of Diabetes2013，4，4： | 6 |
| 2 | Meta‐analysis of insulin aspart versus regular human insulin used in a basal–bolus regimen for the treatment of diabetes mellitus (在基础—餐时糖尿病治疗方案中使用门冬胰岛素与使用常规人胰岛素对照研究的Meta分析)显示文摘 | Simon Heller Bruce Bode Plamen Kozlovski Anne Louise Svendsen | 2013 | Journal of Diabetes2013，，4： | 5 |
| 3 | Chromium intake, absorption and excretion of subjects consuming self-selected diets 显示文摘 | Anderson R A Kozlovsky A S | 1985 | American Journal of Clinical Nutrition1985，41，6： | 1 |
| 4 | Generation of 41 mW of blue radiation by frequency doubling of a GaAlAs diode laser 显示文摘 | Kozlovsky W J Length W Latta E E | 1990 | Appl Phys Lett1990，56，23： | 1 |
| 5 | Long-term down-regulation of BDNF mRNA in rat hippocampal CA1 subregion correlates with PTSD-like behavioural stress response显示文摘 | Kozlovsky N Matar MA Kaplan Z | 2007 | Int J Neuropsychopharmacol2007，10，： | 1 |
| 6 | The immediate early gene Arc is associated with behavioral resilience to stress exposure in an animal model of posttraumatic stress disorder显示文摘 | Kozlovsky N Matar MA Kaplan Z | 2008 | Eur Neuropsychopharma2008，18，： | 1 |
| 7 | The role of the galaninergic system in modulating stress-related responses in an animal model of posttraumatic stress disorder显示文摘 | Kozlovsky N Matar MA Kaplan Z | 2009 | Biol Psychiatry2009，65，： | 1 |
| 8 | Chiral polymers with photoaffected phase behaviourfor photoopti-cal and optoelectronic applications 显示文摘 | Kozlovsky M V | 2002 | Synth Metal2002，127，： | 1 |
| 9 | The neuropeptide Y (NPY)-ergic system is associated with behavioral resilience to stressexposure in an animal model of post-traumatic stress disorder显示文摘 | Cohen H Liu T Kozlovsky N | 2012 | Neuropsychopharmacol2012，37，2： | 1 |
| 10 | Impact of implant overloading on the peri-implant bone in flamed and non-inflamed peri-implant mucosa显示文摘 | Kozlovsky A Tal H Laufer BZ | | 0，，05： | 1 |
| 11 | High dose hy-drocortisone immediately after trauma may alter the traj-ectory of PTSD:interplay between clinical and animalstudies显示文摘 | Zohar J Yahalom H Kozlovsky N | 2011 | Eur Neuropsychopharmacol?2011，21，11： | 1 |
| 12 | 显示文摘 | Korostelin Y V Kozlovsky V I Nasibov A S | 1999 | Journal of Crystal Growth1999，197，3： | 1 |
| 13 | The neuropeptide Y (NPY) -ergic system is associatedwith behavioral resilience to stress exposure in an animal model of posttraumatic stress disorder 显示文摘 | Cohen H Liu T Kozlovsky N | 2012 | Neuropsychopharmacology2012，37，2： | 1 |
| 14 | The role of the galaninergic system in modulating stress-related responses in an animal model of posttraumatic stress disorder显示文摘 | Kozlovsky N Matar MA Kaplan Z | | 0，，： | 1 |
| 15 | Hippocampal mi-croinfusion of oxytocin attenuates the behavioural re-sponse to stress by means of dynamic interplay with theglucocorticoid-catecholamine responses显示文摘 | Cohen H Kaplan Z? Kozlovsky N | 2010 | J Neuroendo-crinol2010，22，8： | 1 |
| 16 | Antral computerized tomography preoperative evaluation: relationship between mucosal thickening and maxillary sinus function 显示文摘 | Carmeli G Artzi Z Kozlovsky A | 2011 | Clin Oral Impl2011，22，1： | 1 |
| 17 | Flavonoids and nitric oxide synthase 显示文摘 | OLSZANECKI R GEBSKA A KOZLOVSKI V I | 2002 | J Physiol Pharmaco12002，53，4： | 1 |
| 18 | Improved glycaemic control with vildagliptin added to insulin, with or without metformin, in patients with type 2 diabetes mellitus显示文摘 | W. Kothny J. Foley P. Kozlovski Q. Shao B. Gallwitz V. Lukashevich | 2012 | Diabetes Obes Metab2012，，3： | 1 |
| 19 | Vapour Growth of Ⅱ-Ⅵ Solid Solution Single Crystals by Contact-free Technique显示文摘 | Korostelin Y V Kozlovsky V I | 2004 | Journal of Alloys and Compounds2004，371，12： | 1 |
| 20 | Efficient Laser Operation from Cr^2+:ZnSe Crystals Produced by Seeded Physical Vapor Ttransport Method显示文摘 | Frolov M P Korostelin Y V Kozlovsky V I | 2004 | Proceedings of SPIE-The International Society for Optical Engineering2004，5478，： | 1 |
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