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| 1 | Colitis-associated colon cancer:Is it in your genes?显示文摘Colitis-associated colorectal cancer(CA-CRC) is the cause of death in 10%-15% of inflammatory bowel disease(IBD) patients. CA-CRC results from the accumulation of mutations in intestinal epithelial cells and progresses through a well-characterized inflammation to dysplasia to carcinoma sequence. Quantitative estimates of overall CA-CRC risks are highly variable ranging from 2% to 40% depending on IBD severity, duration and location, with IBD duration being the most significant risk factor associated with CA-CRC development. Recently, studies have identified IBD patients with similar patterns of colonic inflammation, but that differ with respect to CA-CRC development, suggesting a role for additional non-inflammatory risk factors in CA-CRC development. One suggestion is that select IBD patients carry polymorphisms in various low penetrance disease susceptibility genes, which predispose them to CA-CRC development, although these loci have proven difficult to identify in human genomewide association studies. Mouse models of CA-CRC have provided a viable alternative for the discovery, validation and study of individual genes in CA-CRC pathology. In this review, we summarize the current CA-CRC literature with a strong focus on genetic predisposition and highlight an emerging role for mouse models in the search for CA-CRC risk alleles. | Lauren Van Der Kraak Philippe Gros Nicole Beauchemin | 2015 | World Journal of Gastroenterology2015，21，41： | 5 |
| 2 | Research challenges in geovisualization 显示文摘 | M J Kraak | 2001 | Cartographic & Geographic Information System2001，28，1： | 1 |
| 3 | Exposure to bleached kraft pulp milleflluent disrupts the pituitary-gonadal axis of white sucker at multiple sites 显示文摘 | Van Der Kraak G J Mun kittrick K R McMaster M E | 1992 | Toxicol Appl Pharmacol1992，，115： | 1 |
| 4 | The Role of the Map in a Web-GIS Environment 显示文摘 | Kraak M J | 2004 | Journal of Geographical Systems2004，6，2： | 1 |
| 5 | Perovskite -type oxides - catalysts for the total oxidation of chlorinated hydrocarbons 显示文摘 | Kiessling D Schneider R Kraak P | 1998 | Applied Catalysis B-Environmental1998，19，2： | 1 |
| 6 | Uptake and tissue distribution of dietary and aqueous cadmium by carp(Cyprinus carpio)显示文摘 | Kraal M H Kraak M H S Groot C J | 1995 | Ecotoxicology and Environmental Safety1995，31，2： | 1 |
| 7 | Effects of -luteinizing hormone-releasing hormone ( sGnRH-A ) and I D- Ala6, Pro9 Net -luteinizing hormone-releasing hormone(LHRH-A), in combination with pimozide or domperidone, on gonadotropin release and ovulation in the Chinese loach and common carp 显示文摘 | Lin H R Van Der Kraak G Zhou X J | 1988 | General and Comparative Endocrinology1988，69，1： | 1 |
| 8 | Hydropriming, a simple and inexpensive priming method显示文摘 | Fujikura Y Karssen C M Kraak H L | 1993 | Seed Science and Technology1993，21，： | 1 |
| 9 | Principles of hypermaps 显示文摘 | Kraak M J Van Driel R | 1997 | Computers & Geosciences1997，33，1： | 1 |
| 10 | Use of a series of homologous in vitro and in vivo assays to evaluate the endocrine modulating actions of 3-sitosterol in rainbow trout显示文摘 | Louis Tremblay Glen Van Der Kraak | 1998 | Aquatic Toxicology1998，43，： | 1 |
| 11 | Hydro-priming, a simple and inexpensive priming method显示文摘 | Fujikura Y Kraak H L Basra A S et at | 1993 | Seed Science and Technology1993，21，： | 1 |
| 12 | Flow cytometric determination of nuclear replication stages in tomato seeds during priming and germination 显示文摘 | Bino R J de Vries J N Kraak H L | 1992 | Annals of Botany Company1992，69，： | 1 |
| 13 | R-N-(Pentafluoroben- zoyl)phenylglycine as a chiral stationary phase for the separa- tion of enantiomers by high-performance liquid chromatogra- phy 显示文摘 | Kip J Haperen P V Kraak J C | 1986 | Journal of Chromatography A1986，356，： | 1 |
| 14 | Comparison between the effects of the phytosterol β-sitosterol and pulp and paper mill effluents on sexually immature rainbow trout显示文摘 | TREMBI AY L KRAAK G V D | 1999 | Environmental Toxicology and Chemistry1999，18，： | 1 |
| 15 | Interaction in Virtual World Views Linking 3D GIS with VR显示文摘 | Verbree Edward Vanmaren Gert Germs Rick Jansen Frederik Kraak M-J | 1999 | Geographical Information Science1999，，13： | 1 |
| 16 | Horizontal Coordination,Government Performance and National Planning:The Possibilities and Limits of the South African State 显示文摘 | KRAAK A | 2011 | Politikon2011，38，3： | 1 |
| 17 | Selectivity change in the separation of proteins and peptides by capillary electrophoresis using high-molecular-mass polyethyleneimine显示文摘 | Poppe H Kraak J C | 1996 | J Chromatogr A1996，681，： | 1 |
| 18 | Functional characterization of estrogen receptor subtypes, ERa and ERβ, mediating vitellogenin production in the liver of rainbow trout 显示文摘 | Leafios-Castafieda O Van Der Kraak G | 2009 | Gen Comp Endocrinol2009，161，1： | 1 |
| 19 | Modification of silica with glucose for the separation of proteins by high-performance liquid chromatography显示文摘 | HUISDEA R E KRAAK J C POPPE H | 1990 | J Chromatogr1990，508，2： | 1 |
| 20 | Special issue: visualization for exploration of spatial data显示文摘 | Kraak M J MacEachren A M | 1999 | International Journal of Geographical Information Science1999，13，4： | 1 |
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