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| 1 | Predictors of esophageal varices and first variceal bleeding in liver cirrhosis patients显示文摘AIM To assess 'predictors' of esophageal varices(EV) and variceal bleeding using non-invasive markers in Albanian patients diagnosed with liver cirrhosis.METHODS One hundred thirty-nine newly diagnosed cirrhotic patients without variceal bleeding were included in this analysis. Model for end-stage liver disease(MELD), aspartate aminotransferase(AST) to alanine aminotransferase(ALT) ratio(AST/ALT), AST to platelet ratio index(APRI), platelet count to spleen diameter(PC/SD), fibrosis-4-index(FIB-4), fibrosis index(FI) and King's Score were measured for all participants. All patients underwent endoscopic assessment within two days of hospitalization. The major end point was the first esophageal variceal bleeding(EVB) event. The diagnostic performance of 'predictors' for the presence of EV and EVB were assessed by sensitivity and specificity values obtained from the receiver operating characteristics procedure.RESULTS FIB-4 was the only strong and significant 'predictor' of esophageal varices(multivariable-adjusted OR = 1.57 for one unit increment; 95%CI: 1.15-2.14). Furthermore, a cut-off value of 3.23 for FIB-4 was a significant predictor of esophageal varices, with a sensitivity of 72%, a specificity of 58% and a proportion of area under the curve(AUC) of 66%(P = 0.01). During the follow-up(median: 31.5 mo; interquartile range: 11-59 mo), 34 patients(24%) experienced a first EVB. FIB-4 was a poor predictor of EVB(the AUC was only 51%) for a cut-off value of 5.02. Furthermore, the AUC of AST/ALT, APRI, PC/SD, FI, MELD and King's Score ranged from 45% to 55%. None of the non-invasive markers turned out to be a useful predictor of EVB.CONCLUSION Despite the low diagnostic accuracy, FIB-4 appears the most efficient non-invasive liver fibrosis marker which can be used as an initial screening tool for cirrhotic patients. | Bledar Kraja Iris Mone Ilir Akshija Adea Kocollari Skerdi Prifti Genc Burazeri | 2017 | World Journal of Gastroenterology2017，23，26： | 40 |
| 2 | Epidemiology of hepatitis B virus infection in Albania显示文摘AIM:To assess the prevalence and socio-demographic distribution of hepatitis B virus(HBV) infection in Albania.METHODS:Blood samples from 410 unselected schoolboys,666 students,500 military personnel,1286 casual blood donors,378 voluntary blood donors and 640 pregnant women(total 3880 non-vaccinated residents of rural and metropolitan areas from all over Albania;2354(60.7%) male and 1526(39.3%) female;mean age of 26.3 years) were tested during 2004-2006 for hepatitis B surface antigen(HBsAg) and antibodies to hepatitis B virus(anti-HBs) by ELISA.RESULTS:The HBsAg and anti-HBs prevalence were 9.5% and 28.7%,respectively.The highest HBsAg prevalence was evident in the younger age group,such as in schoolchildren(11.8%) and the military(10.6%).Consequently,the anti-HBs prevalence increased with age,from 21.2% in schoolchildren(mean age:15.7 years),to 36.3% in pregnant women(mean age:26.3 years) and 29.7% in voluntary blood donors(mean age:40.1 years).There were no significant differences between males and females.CONCLUSION:Despite the estimated two-fold reduction of HBsAg prevalence in the general population from about 18%-19% to 9.5%,Albania remains a highly endemic country(i.e.over 8% of HBsAg prevalence rate). | Bashkim Resuli Skerdi Prifti Bledar Kraja Tatjana Nurka Mimoza Basho Edita Sadiku | 2009 | World Journal of Gastroenterology2009，15，7： | 9 |
| 3 | Hemorrhagic Fever with Renal Syndrome Associated with Acute Pancreatitis显示文摘Hemorrhagic fever with renal syndrome (HFRS) is a systemic infectious disease caused by Hantaviruses and characterized by fevers, bleeding tendencies, gastrointestinal symptoms and renal failure. It encompasses a broad spectrum of clinical presentations, ranging from unapparent or mild illnesses to fulminant hemorrhagic processes. Among the various complications of HFRS, acute pancreatitis is a rare find. In this report, based on clinical data, laboratory and radiologic examination findings, we describe a clinical case, with HFRS from Dobrava virus, associated with acute pancreatitis. The patient was successfully treated by supportive management. Clinicians should be alert to the possibility of HFRS when examining patients with epidemiological data and symptoms of acute pancreatitis. | Edmond Puca Arben Pilaca Pellumb Pipero Dhimiter Kraja Entela Y Puca | 2012 | Virologica Sinica2012，27，3： | 2 |
| 4 | Do inflammation and pro- coagulation biomarkers contribute to the metabolic syndrome cluster 显示文摘 | Kraja AT Province MA Amett D | 2007 | Nutr Metab(London)2007，4，1： | 1 |
| 5 | An evaluation of the metabolic syndrome in a large multi-ethnic study:the Family Blood Pressure Program显示文摘 | Aldi T Kraja DC Rao Alan B Weder | 2005 | Nutrition&Metabolism2005，2，： | 1 |
| 6 | Do inflammation and procoagulation biomarkers contribute to the metabolic syndrome cluster显示文摘 | Kraja AT Province MA Arnett D | 2007 | Nutr Metab (Lond)2007，4，1： | 1 |
| 7 | Genome-wide linkage mapping for valve calcification susceptibility loci in hypertensive sibships:the Hypertension Genetic Epidemiology Network Study显示文摘 | Bella JN Tang W Kraja A | 2007 | Hypertension2007，49，： | 1 |
| 8 | Do inflammation and procoagulation biomarkers contribute to the metabolic syndrome cluster显示文摘 | KRAJA AT PROVINCE MA ARNETT D | 2007 | Nutr Metab2007，4，： | 1 |
| 9 | An overview of the genomics of metabolic syndrome显示文摘 | Taylor JY Kraja AT de Las Fuentes | 2013 | J Nurs Scholarsh2013，45，1： | 1 |
| 10 | An evaluation of the metabolic syndrome in a large multi-ethnic study:the Family Blood Pressure Program显示文摘 | Kraja AT Rao DC Weder AB | 2005 | Nutr Metab(Lond)2005，2，1： | 1 |
| 11 | An evaluation of the metabolic syndrome in a large multi-ethnic study:the family blood pressure program显示文摘 | Kraja AT Rao DC Weder AB | 2005 | Nutr Meta2005，2，： | 1 |
| 12 | Role of intravenous omeprazole on non-variceal upper gastrointestinal bleeding after endoscopic treat- ment : a comparative study 显示文摘 | Kellici I Kraja B Mone I | 2010 | Med Arh2010，64，6： | 1 |
| 13 | Identification of tropical and temperate maize populations having favorable alleles for yield and other phenotypic traits显示文摘 | Kraja A Dudley J W | 2000 | Crop Science2000，40，4： | 1 |
| 14 | Do inflammation and procoagulation biomarkers contribute to the metabolic syndrome cluster显示文摘 | Kraja AT Province MA Arnett D | 2007 | Nut r Metab (Lond)2007，4，1： | 1 |
| 15 | Reconstruction of the epidemic history of hepatitis B virus genotype D in Albania显示文摘 | Gianguglielmo Zehender Renata Shkjezi Erika Ebranati Elena Gabanelli Zhani Abazaj Elisabetta Tanzi Dhimiter Kraja Silva Bino Massimo Ciccozzi Massimo Galli | 2011 | Infection, Genetics and Evolution2011，，： | 1 |
| 16 | Genotype-by-sex inter- action in the aetiology of type 2 diabetes mellitus: support for sex-specific quantitative trait loci in Hypertension Genetic Epide- miology Network participants 显示文摘 | Avery CL Freedman BI Kraja AT | 2006 | Diabetologia2006，49，10： | 1 |
| 17 | Role of intravenous omeprazole on non variceal upper gastrointestinal bleeding after endoscopie treatment: a comparative study显示文摘 | Kraja B Mone I Prifti S | 2010 | Med Arh2010，64，6： | 1 |
| 18 | An evaluation of the metabolic syndrome in a large multi-ethnic study: the Family Blood Pressure Program显示文摘 | Kraja AT Rao DC Weder AB | 2005 | Nutr Metab (Lond)2005，2，8： | 1 |
| 19 | Do inflammation and procoagulation biomarkers contribute to the metabolic syndrome cluster显示文摘 | Kraja AT Province MA Arnett D | 2007 | Nut r Metab (Lond)2007，4，1： | 1 |
| 20 | Reconstruction of the epidemic history of hepatitis B virus genotype D in Albania显示文摘 | Gianguglielmo Zehender Renata Shkjezi Erika Ebranati Elena Gabanelli Zhani Abazaj Elisabetta Tanzi Dhimiter Kraja Silva Bino Massimo Ciccozzi Massimo Galli | 2011 | Infection Genetics and Evolution2011，，2： | 1 |
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