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| 1 | Proposal of an ultrasonographic classification for hepatic alveolar echinococcosis: Echinococcosis multilocularis Ulm classification-ultrasound显示文摘AIM: To establish an ultrasonographic classification based on a large sample of patients with confirmed hepatic alveolar echinococcosis(AE).METHODS: Clinical data and ultrasonography(US) findings of 185 patients(100 males; 85 females; mean age at diagnosis: 51.4 ± 17.6 years; mean age at time of US examination: 58.7 ± 18.2 years) were retrospectively reviewed with respect to the US morphology of hepatic AE lesions. The sonomorphological findings were grouped according to a five-part classification scheme.RESULTS: Application of the new classification resulted in the following distribution of sonomorphological patterns among the patients examined: hailstorm(54.1%); pseudocystic(13.5%); ossification(13.0%); hemangioma-like(8.1%); and metastasis-like(6.5%). Only 4.9% of lesions could not be assigned to a sonomorphological pattern.CONCLUSION: The sonomorphological classification proposed in the present study facilitates the diagnosis,interpretation and comparison of hepatic alveolar echinococcosis in routine practice and in the context of scientific studies. | Wolfgang Kratzer Beate Gruener Tanja EM Kaltenbach Sarina Ansari-Bitzenberger Peter Kern Michael Fuchs Richard A Mason Thomas FE Barth Mark M Haenle Andreas Hillenbrand Suemeyra Oeztuerk Tilmann Graeter | 2015 | World Journal of Gastroenterology2015，21，43： | 16 |
| 2 | Parameters affecting different acoustic radiation force impulse applications in the diagnosis of fibrotic liver changes显示文摘AIM: To analyze the virtual touch tissue quantification(VTTQ) and virtual touch imaging quantification(VTIQ) techniques, and identify possible factors that may influence VTTQ and VTIQ measurements.METHODS: One hundred and eighty-six(104 women/82 men) of 323 subjects met the inclusion criteria(age > 18 years, no history of chronic or gastrointestinal disease, body-mass index(BMI) < 30 kg/m2, a fasting period of at least three hours, no history of hepatotoxic pharmaceuticals, alcohol consumption < 24 g/d in men and < 12 g/d in women, and normal findings upon ultrasound examination of the abdomen). Measurements were taken at depths of 50 mm with VTTQ, 15 mm and 25 mm with VTIQ in the right hepatic lobe, and at 15 mm with only VTIQ in the left hepatic lobe. The examiner acquired six measurements per position, thereby giving 24 measurements in total.RESULTS: The 95% confidence intervals of mean were1.23-1.29 m/s for VTTQ and 1.29-1.37 m/s, 1.17-1.23 m/s, and 1.48-1.57 m/s for VTIQ in a depth of 15 mm and 25 mm in the right hepatic lobe and 15 mm in the left hepatic lobe. Only superficial measurements in the right hepatic lobe with the VTIQ method exhibited an effect of age on shear wave velocity. Measurements acquired using the 6C1 probe with the VTTQ method showed no dependence on BMI. By comparison, BMI influenced measurements taken with the VTIQ method using the 9L4 probe in the superficial and deep areas of the right hepatic lobe, as well as in the left hepatic lobe(P = 0.0160, P = 0.0019, P = 0.0173, respectively). Gender influenced measurements at depths of 50 mm with VTTQ and 25 mm with VTIQ in the right hepatic lobe(P = 0.0001, P = 0.0269). Significant differences were found between measurements with the 6C1(VTTQ) and 9L4 probes(VTIQ)(P = 0.0067), between superficial and deep measurements(P < 0.0001), and between the right and left lobes of the liver(P < 0.0001). CONCLUSION: Measurements in the right lobe and deep regions are preferable. Gender differences must be considered. BMI must be considered when assessing VTIQ technology. | Sabrina Galgenmueller Heike Jaeger Wolfgang Kratzer Stefan A Schmidt Suemeyra Oeztuerk Mark M Haenle Richard A Mason Tilmann Graeter | 2015 | World Journal of Gastroenterology2015，21，27： | 5 |
| 3 | Prevalence of cholelithiasis in patients with chronic inflammatory bowel disease显示文摘AIM: To investigate the effect of chronic inflammatory bowel disease (CIBD) specific risk factors for cholecystolithiasis,as duration and involvement pattern of the disease and prior surgery in patients with Crohn's disease (CD) and ulcerative colitis (UC).METHODS: A total of 222 patients with CD (135 females,87 males; average age, 35.8±11.8 years; range 17-81 years)and 88 patients with UC (39 females, 49 males; average age, 37.2±13.6 years; range 16-81 years) underwent clinical and ultrasound examinations. Besides age, sex and degree of obesity, patients' CIBD specific parameters, including duration and extent of disease and prior operations were documented and evaluated statistically using logistic regression.RESULTS: The overall prevalence of gallbladder stone disease in patients with CD was 13% (n = 30). Only age could be shown to be an independent risk factor (P = 0.014).Compared to a collective representative for the general population in the same geographic region, the prevalence of cholecystolithiasis was higher in all corresponding age groups. Patients with UC showed an overall prevalence of gallbladder stone disease of only 4.6%.CONCLUSION:Only age but not disease-specific factors such as duration and extent of disease, and prior surgery are independent risk factors for the development of cholecystolithiasis in patients with CIBD. | Wolfgang Kratzer Mark M Haenle Richard A Mason Christian von Tirpitz Volker Kaechele | 2005 | World Journal of Gastroenterology2005，11，39： | 3 |
| 4 | Kontrastmittelsonografie bei B-Bild-morphologisch unklaren Leberraumforderungen – Diagnostische Treffsicherheit im klinischen Alltag (DEGUM-Multicenter – Studie)显示文摘 | D Strobel K Seitz W Blank A Schuler C Dietrich A Herbay M Friedrich-Rust G Kunze D Becker U Will W Kratzer F Albert C Pachmann K Dirks H Strunk C Greis T Bernatik | 2008 | Ultraschall in Med2008，，05： | 2 |
| 5 | Postmortem stability of DNA显示文摘 | Bar W Kratzer A Machler M | 1988 | Forensic Sci Int1988，39，1： | 1 |
| 6 | Estimating the maximum effective dose in aquantitative dose-response experiment 显示文摘 | Remmenga M D Milliken G A Kratzer D | 1997 | J Anim Sci1997，75，： | 1 |
| 7 | Postmortem stability of DNA 显示文摘 | Bar W Kratzer A Machler M | 1988 | Forensic Sci Int1988，39，1： | 1 |
| 8 | The social structure of leadership and creativity in engineering design teams : an empirical analysis 显示文摘 | KRATZER J LEENDERS R T A J VAN ENGELEN J M L | 2008 | Journal of engineering and technolo management2008，25，4： | 1 |
| 9 | TG1050,an immunotherapeutic to treat chronic hepatitis B,induces robust T cells and exerts an antiviral effect in HBVpersistent mice显示文摘 | Martin P Dubois C Jacquier E Dion S ManciniBourgine M Godon O Kratzer R Lelu-Santolaria K Evlachev A Meritet J F Schlesinger Y Villeval D Strub J M Van Dorsselaer A Marchand J B Geist M Brandely R Findeli A Boukhebza H Menguy T Silvestre N Michel M L InchauspéG | 2015 | Gut2015，64，12： | 1 |
| 10 | Estimating the maximum effective dose in a quantitative dose-response experiment显示文摘 | Remmenga M D Milliken G A Kratzer D | 1997 | J Anim Sci1997，75，： | 1 |
| 11 | Mature dendritic cells infected with herpes simplex virus type I exhibited T-cell stimulatory capacity显示文摘 | Kruse M Rosorius O Kratzer F | 2000 | J Virol2000，74，15： | 1 |
| 12 | The role of Cys108 in Trigonopsis variabilis d-amino acid oxidase examined through chemical oxidation studies and point mutations C108S and C108D显示文摘 | Mueller M Kratzer R Schiller M | 2010 | Biochimica et Biophysica Acta2010，1804，7： | 1 |
| 13 | For-mation and stability of self-assembled coherent islands in highly mismatched heteroepitaxy显示文摘 | WANG L G KRATZER P SCHEFFLER M | 1999 | Physical Review Let-ters1999，82，20： | 1 |
| 14 | Effect of excess leucine on feather structure and feather composition in the chick显示文摘 | Penz A M Kratzer F H Rogers Q R | 1984 | Nutrition Report International1984，29，4： | 1 |
| 15 | Postmortem stability of DNA显示文摘 | Kratzer A Machler M | 1988 | Forensic Sci Int1988，39，1： | 1 |
| 16 | Developmental change in the electrophysiological and pharmacological properties of acid-sensing ion channels in CNS neurons显示文摘 | Li M Kratzer E Inoue K | 2010 | I Physiol2010，588，20： | 1 |
| 17 | Synthetic LXR agonist at-tenuates plaque formation in apoE-/-mice without inducing liversteatosis and hypertriglyceridemia显示文摘 | Kratzer A Buchebner M Pfeifer T | 2009 | J Lipid Res2009，50，2： | 1 |
| 18 | Psychological safety, knowledge sharing, and creative performance in healthcare teams显示文摘 | Kessel M Kratzer J Schultz C | 2012 | Creativity and Innovation Management2012，21，2： | 1 |
| 19 | Virtuality,communication,and new product team creativity:a social network perspective显示文摘 | LEENDERS R VAN ENGELEN J M L KRATZER J | 2003 | Journal of Engineering and Technology Management2003，20，： | 1 |
| 20 | Mature dendritic cells infected with herpes simplex virus type 1 exhibit inhibited T- cell stimulatory capacity显示文摘 | Kruse M Rosorius O Kratzer F | 2000 | J Virol2000，74，15： | 1 |
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