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| 1 | Fusobacterium 's link to colorectal neoplasia sequenced: A systematic review and future insights显示文摘AIM To critically evaluate previous scientific evidence on Fusobacterium's role in colorectal neoplasia development.METHODS Two independent investigators systematically reviewed all original scientific articles published between January,2000,and July,2017,using Pub Med,EMBASE,and MEDLINE. A total of 355 articles were screened at the abstract level. Of these,only original scientific human,animal,and in vitro studies investigating Fusobacterium and its relationship with colorectal cancer(CRC) were included in the analysis. Abstracts,review articles,studies investigating other colonic diseases,and studies written in other languages than English were excluded from our analysis. Ninety articles were included after removing duplicates,resolving disagreements between the two reviewers,and applying the above criteria.RESULTS Studies have consistently identified positive associations between Fusobacterium,especially Fusobacterium nucleatum(F. nucleatum),and CRC. Stronger associations were seen in CRCs proximal to the splenic flexure and Cp G island methylator phenotype(CIMP)-high CRCs. There was evidence of temporality and a biological gradient,with increased F. nucleatum DNA detection and quantity along the traditional adenoma-carcinoma sequence and in CIMP-high CRC precursors. Diet may have a differential impact on colonic F. nucleatum enrichment;evidence suggests that high fiber diet may reduce the risk of a subset of CRCs that are F. nucleatum DNA-positive. Data also suggest shorter CRC and disease-specific survival with increased amount of F. nucleatum DNA in CRC tissue. The pathophysiology of enrichment of F. nucleatum and other Fusobacterium species in colonic tissue is unclear;however,the virulence factors and changes to the local colonic environment with disruption of the protective mucus layer may contribute. The presence of a host lectin(Gal-Gal NAc) in the colonic epithelium may also mediate F. nucleatum attachment to CRC and precursors through interaction with an F. nucleatum protein,fibroblast activation protein 2(FAP2). The clinical significance of detection or enrichment of Fusobacterium in colorectal neoplasia is ambiguous,but data suggest a procarcinogenic effect of F. nucleatum,likely due to activation of oncogenic and inflammatory pathways and modulation of the tumor immune environment. This is hypothesized to be mediated by certain F. nucleatum strains carrying invasive properties and virulence factors such as Fad A and FAP.CONCLUSION Evidence suggests a potential active role of Fusobacterium,specifically F. nucleatum,in CRC. Future prospective and experimental human studies would fill an important gap in this literature. | Hisham Hussan Steven K Clinton Kristen Roberts Michael T Bailey | 2017 | World Journal of Gastroenterology2017，23，48： | 9 |
| 2 | Risk factors and implications of anastomotic complications after surgery for Crohn's disease显示文摘Anastomotic complications occur more frequently in patients with Crohn's disease leading to postoperative intra-abdominal septic complications(IASC). Patients with IASC often require re-operation or drainage to controlthe sepsis and have an increased frequency of disease recurrence. The aim of this article was to examine the factors affecting postoperative IASC in Crohn's disease after anastomoses, since some risk factors remain controversial. Studies investigating IASC in Crohn's operations were included, and all risk factors associated with IASC were evaluated: nutritional status, presence of abdominal sepsis, medication use, Crohn's disease type, duration of disease, prior operations for Crohn's, anastomotic technique, extent of resection, operative timing, operative length, and perioperative bleeding. In this review, the factors associated with an increased risk of IASC are preoperative weight loss, abdominal abscess present at time of surgery, prior operation, and steroid use. To prevent IASC in Crohn's patients, preoperative optimization with nutritional supplementation or drainage of abscess should be performed, or a diverting stoma should be considered for patients with multiple risk factors. | Kristen T Crowell Evangelos Messaris | 2015 | World Journal of Gastrointestinal Surgery2015，7，10： | 6 |
| 3 | Efficacy and safety of liquid nitrogen cryotherapy for treatment of Barrett's esophagus显示文摘AIM To evaluate the efficacy and safety of liquid nitrogen cryotherapy as a primary or rescue treatment for BE,with and without dysplasia,or intramucosal adenocarcinoma (IMC).METHODS This was a retrospective,single-center study carried out in a tertiary care center including 45 patients with BE who was treatment-na?ve or who had persistent intestinal metaplasia(IM),dysplasia,or IMC despite prior therapy.Barrett's mucosa was resected via EMR when clinically appropriate,then patients underwent cryotherapy until eradication or until deemed to have failed treatment.Surveillance biopsies were taken at standard intervals.RESULTS From 2010 through 2014,33 patients were studied regarding the efficacy of cryotherapy.Overall,29 patients (88%) responded to cryotherapy,with 84% having complete regression of all dysplasia and cancer.Complete eradication of cancer and dysplasia was seen in 75% of subjects with IMC; the remaining two subjects did not respond to cryotherapy.Following cryotherapy,15 patients with high-grade dysplasia (HGD) had 30% complete regression,50% IM,and 7% low-grade dysplasia (LGD); one subject had persistent HGD.Complete eradication of dysplasia occurred in all 5 patients with LGD.In 5 patients with IM,complete regression occurred in 4,and IM persisted in one.In 136 cryotherapy sessions amongst 45 patients,adverse events included chest pain (1%),stricture (4%),and one gastrointestinal bleed in a patient on dual antiplatelet therapy who had previously undergone EMR.CONCLUSION Cryotherapy is an efficacious and safe treatment modality for Barrett's esophagus with and without dysplasia or intramucosal adenocarcinoma. | Kristen Suchniak-Mussari Charles E Dye Matthew T Moyer Abraham Mathew Thomas J McGarrity Eileen M Gagliardi Jennifer L Maranki John M Levenick | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，9： | 4 |
| 4 | N-terminal pro-B-type natriuretic peptide is a major predictor of the development of atrial fibrillation显示文摘 | Kristen K Patrick T Susan R | 2009 | Circulation2009，120，： | 1 |
| 5 | Reaction kinetics and optimization of the copper-catalyzed oxidation of ApoA-1M 显示文摘 | Sa V H Joseph K M Kristen E T | 2009 | Chemical Engineering Science2009，64，： | 1 |
| 6 | DNA sequence of the skeletal muscle calcium release channel cDNA and verification of the Arg 615-Cys 615 mutation associated with porcine malignant hyperthermia in Norwegian Landrace pigs 显示文摘 | Harbitz I Kristen T Bosnes M | 1992 | Animal Genetics1992，23，： | 1 |
| 7 | Functional food products made from fish protein isolate recovered with iso- electric solubilization/precipitation显示文摘 | Reza T Sarah KB Kristen EM | 2012 | LWT-Food Science and Technology2012，48，1： | 1 |
| 8 | Diseordent atrial natri- uretic peptide and brain natriuretic peptide levels in lone atrial fibrillation显示文摘 | Patrick T E Adrian F Kristen K | 2005 | J Am Coil Cardio2005，45，： | 1 |
| 9 | Chemical properties of x-3 fortified gels made of protein isolate recovered with isoelectrie solubilisation/precipitation from whole fish 显示文摘 | Reza T Sarah K B Kristen E | 2013 | Food Chemistry2013，139，： | 1 |
| 10 | Fish protein isolate: Development of functional foods with nutraceutical ingredients 显示文摘 | Reza T Kristen E M Jacek J | 2014 | Journal of Functional Foods2014，18，： | 1 |
| 11 | Optimistic bias in the perception of personal risk : patterns in Schizophrenia 显示文摘 | KRISTEN J P JAMES M G WILLIAM T C | 2005 | Am J Psy- chi2005，162，3： | 1 |
| 12 | HIV Testing Frequency Among Men Who Have Sex With Men Attending Sexually Transmitted Disease Clinics: Implications for HIV Prevention and Surveillance显示文摘 | Donna J Helms Hillard S Weinstock Kristen C Mahle Kyle T Bernstein Bruce W Furness Charlotte K Kent Cornelis A Rietmeijer Akbar M Shahkolahi James P Hughes Matthew R Golden | 2009 | JAIDS Journal of Acquired Immune Deficiency Syndromes2009，，3： | 1 |
| 13 | DNA sequence of the akele- tal muscles calcium release channel cDNA and verification of the Arg 615 - Cys mutation, associated with porcine malignant hyper- thermia, in Norwegian Landrace pigs显示文摘 | Haibitz I Kristen T Bosttes M | 1992 | Animal Genetics1992，23，5： | 1 |
| 14 | Applied re- pairable-item Inventory Modeling in the Aviation Industry 显示文摘 | Kristen T Florian yon der H Daniel S | 2013 | Procedia CIRP2013，11，： | 1 |
| 15 | Current diagnostic and therapy of light chain amyloidosis 显示文摘 | Schonland SO Bochtler T Kristen AV | 2009 | Pathologe2009，30，3： | 1 |
| 16 | DNA sequence of the akeletalmuscles calcium release channel cDNA and verification of the Arg615-Cys mutationy associated with porcine malignant hyperthermia,inNorwegian Landrace pigs显示文摘 | Haibitz I Kristen T Bosttes M | 1992 | Animal Genetics1992，23，： | 1 |
| 17 | The Pivotal Role of IKKα in the Development of Spontaneous Lung Squamous Cell Carcinomas显示文摘 | Zuoxiang Xiao Qun Jiang Jami Willette-Brown Sichuan Xi Feng Zhu Sandra Burkett Timothy Back Na-Young Song Mahesh Datla Zhonghe Sun Romina Goldszmid Fanching Lin Travis Cohoon Kristen Pike Xiaolin Wu David S. Schrump Kwok-Kin Wong Howard A. Young Giorgio T | 2013 | Cancer Cell2013，，4： | 1 |
| 18 | Current diagnostic and therapy of light chain amyloidosis显示文摘 | Schonland SO Bochtler T Kristen AV | 2009 | Pathologe2009，30，： | 1 |
| 19 | Using Focus Group Data to Set New Product Prices 显示文摘 | THEOFORE T KRISTEN M | 2004 | Journal of Product & Brand Management2004，13，1： | 1 |
| 20 | DNA sequence of the skeletal muscle calcium release channel cDNA and verification of the Arg 615-Cys 615 mutation,associated with porcine malignant hyperthermia, in Norwegian Landrace pigs显示文摘 | Harbitz I Kristen T Bosnes M | 1992 | Animal Genetics1992，23，： | 1 |
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