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| 1 | Cardiometabolic health among gastric bypass surgery patients with polycystic ovarian syndrome显示文摘AIM:To examine the effect of gastric bypass surgery on cardiometabolic health among women with polycystic ovarian syndrome(PCOS).METHODS:Retrospective medical chart review identified women(n = 389) with PCOS who underwent Roux-en-Y gastric bypass surgery from 2001-2009 in one surgical practice.Separate repeated measures linear mixed models were fit using the MIXED procedureto assess mean change in cardiometabolic disease risk factors from before to 1-year after surgery and were evaluated by ethnicity [Hispanic,non-Hispanic black(NHB) and white(NHW)].RESULTS:The majority of the sample was Hispanic(66%,25% NHB,9% NHW).Mean body mass index significantly improved 1 year post-surgery for all ethnic groups(45.5 to 35.5 kg/m2 for Hispanics,46.8 to 37.7 kg/m2 for NHB and 45.7 to 36.7 kg/m2 for NHW,P < 0.001).Among Hispanic women mean total cholesterol(198.1 to 160.2 mg/dL),low-density lipoproteins(LDL) cholesterol(120.9 to 91.0 mg/dL),triglycerides(148.6 to 104.8 mg/dL),hemoglobin A1c(6.2% to 5.6%),alanine aminotransferase(28.1 to 23.0 U/L) and aspartate aminotransferase(23.5 to 21.6 U/L) decreased significantly(P < 0.001).Among NHB,mean total cholesterol(184.5 to 154.7 mg/dL),LDL cholesterol(111.7 to 88.9 mg/dL) and triglycerides(99.7 to 70.0 mg/dL) decreased significantly(P < 0.05).Among NHW,mean total cholesterol(200.9 to 172.8 mg/dL) and LDL cholesterol(124.2 to 96.6 mg/dL),decreased significantly(P < 0.05).Pairwise ethnic group comparisons of all cardiometabolic outcomes adjusted for age and type of surgery before and 1 year after surgery showed no statistical difference between the three groups for any outcome.CONCLUSION:Cardiometabolic disease risk improvements vary by ethnicity and obesity may impact glucose tolerance and liver function changes more in Hispanic women with PCOS vs non-Hispanic women. | Carley A Gomez-Meade Adriana Carrillo Gabriela Lopez-Mitnik Sarah E Messiah Kristopher L Arheart Nestor de la Cruz-Muoz | 2013 | World Journal of Diabetes2013，4，3： | 6 |
| 2 | Metabolite profile comparisons between ascending and descending colon tissue in healthy adults显示文摘BACKGROUND Obesity is a risk factor for colorectal cancer,yet metabolic distinctions between healthy right and left colon tissue,before cancer is diagnosed,remains largely unknown.This study compared right-ascending and left-descending colon tissue metabolomes to identify differences from the stool metabolome in normal weight,overweight,and obese adults.AIM To examine right and left colon tissue metabolites according to body mass index that may serve as mechanistic targets for interventions and biomarkers for colon cancer risk.METHODS Global,non-targeted metabolomics was applied to assess right-ascending and left-descending colon tissue collected from healthy adults undergoing screening colonoscopies to test the hypothesis that BMI differentially impacts colon tissue metabolite profiles.The colon tissue and stool metabolome of healthy adults(n=24)was analyzed for metabolite signatures and metabolic pathway networks implicated in progression of colorectal cancer.RESULTS Ascending and descending colon contained 504 host,food,and microbiotaderived metabolites from normal weight,overweight and obese adults grouped according to body mass index.Amino acids,lipids,and nucleotides were among the chemical types that further differentiated from the stool metabolite profiles.Normal weight adults had 46 significantly different metabolites between ascending and descending colon tissue locations,whereas there were 37 metabolite differences in overweight and 28 metabolite differences for obese adults(P<0.05).Obese adults had trimethylamine N-oxide,endocannabinoids and monoacylglycerols with different relative abundances identified between ascending and descending colon.Primary and secondary bile acids,vitamins,and fatty acids also showed marked relative abundance differences in colon tissue from overweight/obese adults.CONCLUSION There were metabolite profile differences between right-ascending and leftdescending colon tissue in healthy adults.Colon lipids and other metabolites in obese and overweight adults were distinguished from normal weight participants and associated with gut inflammation,nutrient absorption,and products of microbiota metabolism. | Bridget A Baxter Kristopher D Parker Michael J Nosler Sangeeta Rao Rebecca Craig Catherine Seiler Elizabeth P Ryan | 2020 | World Journal of Gastroenterology2020，26，3： | 2 |
| 3 | Obesity and cardiometabolic disease risk factors among US adolescents with disabilities显示文摘AIM: To generate prevalence estimates of weight status and cardiometabolic disease risk factors among adolescents with and without disabilities.METHODS: Analysis of the 1999-2010 National Health and Nutrition Examination Survey data was conducted among 12-18 years old with(n = 256) and without disabilities(n = 5020). Mean values of waist circumference, fasting glucose, high-density-lipoprotein cholesterol, triglycerides, systolic and diastolic blood pressure and metabolic syndrome(Met S, ≥ 3 risk factors present) were examined by the following standardized body mass index(BMI) categories for those with and without disabilities; overweight(BMI ≥ 85th- < 95 th percentile for age and sex), obesity(BMI ≥ 95 th percentile) and severe obesity(BMI ≥35 kg/m2). Linear regression models were fit with each cardiometabolic disease risk factor independently as continuous outcomes to show relationships with disability status. RESULTS: Adolescents with disabilities were significantlymore likely to be overweight(49.3%), obese(27.6%) and severely obese(12%) vs their peers without disabilities(33.1%, 17.5% and 3.6%, respectively, P ≤ 0.01 for all). A higher proportion of overweight, obese and severely obese children with disabilities had abnormal SBP, fasting lipids and glucose as well as Met S(18.9% of overweight, 32.3% of obese, 55% of severely obese) vs their peers without disabilities(9.7%, 16.8%, 36.3%, respectively). US adolescents with disabilities are over three times as likely to have Met S(OR = 3.45, 95%CI: 1.08-10.99, P = 0.03) vs their peers with no disabilities.CONCLUSION: Results show that adolescents with disabilities are disproportionately affected by obesity and poor cardiometabolic health vs their peers with no disabilities. Health care professionals should monitor the cardiometabolic health of adolescents with disabilities. | Sarah E Messiah Denise C Vidot Gabriel Somarriba Kanathy Haney Semra Aytur Ruby A Natale Jeffrey P Brosco Kristopher L Arheart | 2015 | World Journal of Diabetes2015，6，1： | 2 |
| 4 | Bringing the Excitement and Motivation of Research to Students; Using Inquiry and Research- Based Learning in a Year-Long Biochemistry Laboratory 显示文摘 | Kristopher K Jennifer S Mark A | 2010 | Bio- chemistry and Molecular Biology Education2010，5，38： | 1 |
| 5 | Functionalization of acetylene-terminated monolay-ers on Si (100) surfaces:A click chemistry approach显示文摘 | Simone Ciampi Till B(o)cking Kristopher A Kilian | 2007 | Langmuir2007，23，18： | 1 |
| 6 | Hybrid lipid bilayers in nanostructured silicon : A biomimetic mesoporous scaffold for optical detection of cholera toxin 显示文摘 | Kristopher A K Till B Katharina G | 2007 | Chemical Communications2007，21，19： | 1 |
| 7 | Neonatal infratentorial subdural hematoma contributing to obstructive hydrocephalus in the setting of therapeutic cooling: A case report显示文摘BACKGROUND Symptomatic neonatal subdural hematomas usually result from head trauma incurred during vaginal delivery,most commonly during instrument assistance.Symptomatic subdural hematomas are rare in C-section deliveries that were not preceded by assisted delivery techniques.Although the literature is inconclusive,another possible cause of subdural hematomas is therapeutic hypothermia.CASE SUMMARY We present a case of a term neonate who underwent therapeutic whole-body cooling for hypoxic ischemic encephalopathy following an emergent C-section delivery for prolonged decelerations.Head ultrasound on day of life 3 demonstrated a rounded mass in the posterior fossa.A follow-up brain magnetic resonance imaging confirmed hypoxic ischemic encephalopathy and clarified the subdural hematomas in the posterior fossa causing mass effect and obstructive hydrocephalus.CONCLUSION The aim of this report is to highlight the rarity and importance of mass-like subdural hematomas causing obstructive hydrocephalus,particularly in the setting of hypoxic ischemic encephalopathy and therapeutic whole-body cooling. | Lee K Rousslang Elizabeth A Rooks Jaren T Meldrum Kristopher G Hooten Jonathan R Wood | 2021 | World Journal of Radiology2021，13，9： | 1 |
| 8 | AVO/AVF analysis of thin-bed in elastic media显示文摘 | PAN Wen-yong Kristopher A | 2013 | SEG Houston 2013 Annual Meeting2013，，： | 1 |
| 9 | Expression of ERG, an Ets family transcription factor, distinguishes cutaneous angiosarcoma from histological mimics显示文摘 | Kristopher M McKay Leona A Doyle Alexander J Lazar Jason L Hornick | 2012 | Histopathology2012，，5： | 1 |
| 10 | Characterizing heat release rates using an inverse fire modeling technique 显示文摘 | Kristopher J 0 Ofodike A E | 2012 | Fire Technology2012，48，4： | 1 |
| 11 | Evaluating shortfalls in mixed-integer programming approaches for the optimal design and dispatch of distributed generation systems 显示文摘 | KRISTOPHER A P ROBERT J B ALEXANDRA M | 2013 | Applied Energy2013，102，： | 1 |
| 12 | Photochemical fate of sulfa drugs in the aquatic environment : sulfa drugs containing five-membered heterocyclic groups 显示文摘 | Boreen A L Arnold W A Kristopher M N | 2004 | Environmental Science & Technology2004，38，14： | 1 |
| 13 | Expression of ERG, an Ets family transcription factor, distinguishes cutaneous angiosarcoma from histological mimics显示文摘 | Kristopher M McKay Leona A Doyle Alexander J Lazar Jason L Hornick | 2012 | Histopathology2012，，5： | 1 |
| 14 | Comparison of rhizesphere bacterial communitiesin arabidopsis thaliana mutants for systemic acquired resistance显示文摘 | John Whein Gordon V Wolfe Kristopher A Blee | 2008 | Microbial Ecology2008，55，： | 1 |
| 15 | Comparison of rhizosphere bacterial communitiesin arabidopsis thaliana mutants for systemic acquired resistance显示文摘 | John Whein Gordon V Wolfe Kristopher A Blee | 2008 | Microbial Ecology2008，55，： | 1 |
| 16 | Ra- diation Metabolomics: Identification of Minimally Invasive Urine Biomarkers for Gamma-radiation Exposure in Mice 显示文摘 | Tyburski J B Patterson A D Kristopher W K | 2008 | Radiation Research2008，170，1： | 1 |
| 17 | Ra- diation Metabolomics 2: Dose and Time Dependent Urinary Ecretion of Deaminated Purines and Pyrimidines after Sub- lethal Gamma-radiation Exposure in Mice显示文摘 | Tyburski J B Patterson A D Kristopher W K | 2009 | Radiation Research2009，172，1： | 1 |
| 18 | Expression of ERG, an Ets family transcription factor, distinguishes cutaneous angiosareoma from histological mimics 显示文摘 | Kristopher M M Leona A D Alexander J L | 2012 | Histopathology2012，61，5： | 1 |
| 19 | Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus显示文摘 | Boyd Y Kristopher M C Elizabeth A F | 2003 | PNAS(Proc Natl Acad Sci)2003，100，12： | 1 |
| 20 | Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus显示文摘 | Boyd Yount Kristopher M Curtis Elizabeth A Fritz | 2003 | PNAS2003，100，12： | 1 |
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