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| 1 | Intraoperative cell salvage with autologous transfusion in liver transplantation显示文摘Liver transplant(LT) is the primary treatment for patients with end-stage liver disease. About 25000 LTs are performed annually in the world. The potential for intraoperative bleeding is quite variable. However, massive bleeding is common and requires blood transfusion. Allogeneic blood transfusion has an immunosuppressive effect and an impact on recipient survival, in addition to the risk of transmission of viral infections and transfusion errors, among others.Techniques to prevent excessive bleeding or to use autologous blood have been proposed to minimize the negative effects of allogeneic blood transfusion.Intraoperative reinfusion of autologous blood is possible through previous selfdonation or blood collected during the operation. However, LT does not normally allow autologous transfusion by prior self-donation. Hence, using autologous blood collected intraoperatively is the most feasible option. The use of intraoperative blood salvage autotransfusion(IBSA) minimizes the perioperative use of allogeneic blood, preventing negative transfusion effects without negatively impacting other clinical outcomes. The use of IBSA in patients with cancer is still a matter of debate due to the theoretical risk of reinfusion of tumor cells. However, studies have demonstrated the safety of IBSA in several surgical procedures, including LT for hepatocellular carcinoma. Considering the literature available to date, we can state that IBSA should be routinely used in LT, both in patients with cancer and in patients with benign diseases. | Marcelo A Pinto Marcio F Chedid Leo Sekine Andre P Schmidt Rodrigo P Capra Carolina Prediger Jo?o E Prediger Tomaz JM Grezzana-Filho Cleber RP Kruel | 2019 | World Journal of Gastrointestinal Surgery2019，11，1： | 16 |
| 2 | Survival rates according to barcelona clinic liver cancer sub-staging system after transarterial embolization for intermediate hepatocellular carcinoma显示文摘AIM: To investigate the survival rates after transarterial embolization(TAE).METHODS: One hundred third six hepatocellular carcinoma(HCC) patients [90 barcelona clinic liver cancer(BCLC) B] were submitted to TAE between August 2008 and December 2013 in a single center were retrospectively studied. TAE was performed via superselective catheterization followed by embolization with polyvinyl alcohol or microspheres. The date of the first embolization until death or the last follow-up date was used for the assessment of survival. The survival rates were calculated using the Kaplan-Meier method, and the groups were compared using the log-rank test.RESULTS: The overall mean survival was 35.8 mo(95%CI: 25.1-52.0). The survival rates of the BCLC A patients(33.7%) were 98.9%, 79.0% and 58.0% at 12, 24 and 36 mo, respectively, and the mean survival was 38.1 mo(95%CI: 27.5-52.0). The survival rates of the BCLC B patients(66.2%) were 89.0%, 69.0% and 49.5% at 12, 24 and 36 mo, respectively, and the mean survival was 29.0 mo(95%CI: 17.2-34). The survival rates according to the BCLC B sub-staging showed significant differences between the groups, with mean survival rates in the B1, B2, B3 and B4 groups of 33.5 mo(95%CI: 32.8-34.3), 28.6 mo(95%CI: 27.5-29.8), 19.0 mo(95%CI: 17.2-20.9) and 13 mo, respectively(P = 0.013).CONCLUSION : The BCLC sub-stagingsystem could add additional prognosis information for postembolization survival rates in HCC patients. | Leandro Armani Scaffaro Steffan Frosi Stella Mario Reis Alvares-Da-Silva Cleber Dario Pinto Kruel | 2015 | World Journal of Hepatology2015，7，3： | 8 |
| 3 | Liver preservation prior to transplantation: Past, present, and future显示文摘Since Dr. Thomas Starzl performed the first series of successful liver transplants(LTs), important advances have been made in immunosuppression, operative techniques, and postoperative care. In 1988, Belzer's group reported the first successful LT using the University of Wisconsin preservation solution(UW).Since then, UW has replaced EuroCollins solution and allowed prolonged and safer preservation of liver, kidney, and pancreas allografts, thus contributing to the improvement of transplant outcomes. Although UW is still considered the standard of care in the United States and in several countries worldwide, a recent meta-analysis revealed similar LT outcomes among UW, Celsior solution, and the Institut Georges Lopez-1 preservation solution, which were slightly superior to those obtained with histidine-tryptophan-ketoglutarate preservation solution.Dynamic preservation has been recently developed, and liver allografts are preserved mainly through the following methods: hypothermic machine perfusion, normothermic machine perfusion, and subnormothermic machine perfusion. Their use has the potential advantage of improving clinical results in LT involving extended criteria donor allografts. Although associated with increased costs, techniques employing machine perfusion of liver allografts have been considered clinically feasible. This editorial focuses on recent advances and future perspectives in liver allograft preservation. | Marcio F Chedid Marcelo A Pinto Jose Felipe G Juchem Tomaz J M Grezzana-Filho Cleber R P Kruel | 2019 | World Journal of Gastrointestinal Surgery2019，11，3： | 4 |
| 4 | Giant hepatic extra-gastrointestinal stromal tumor treated with cytoreductive surgery and adjuvant systemic therapy:A case report and review of literature显示文摘BACKGROUND Primary extra-gastrointestinal stromal tumors(E-GIST)of the liver are rare.The clinical presentation may range from asymptomatic to bleeding or manifestations of mass effect.Oncologic surgery followed by adjuvant therapy with imatinib is the standard of care.However,under specific circumstances,a cytoreductive approach may represent a therapeutic option.We describe herein the case of an 84-year-old woman who presented with a tender,protruding epigastric mass.Abdominal computed tomography scan revealed a large,heterogeneous mass located across segments III,IV,V,and VIII of the liver.The initial approach was transarterial embolization of the tumor,which elicited no appreciable response.Considering the large size and central location of the tumor and the advanced age of the patient,non-anatomic complete resection was indicated.Due to substantial intraoperative bleeding and hemodynamic instability,only a near-complete resection could be achieved.Histopathology and immunohistochemical staining confirmed the diagnosis of primary E-GIST of the liver.Considering the risk/benefit ratio for therapeutic options,debulking surgery may represent a strategy to control pain and prolong survival.CASE SUMMARY Here,we present a case report of a patient diagnosed with E-GIST primary of the liver,which was indicated a cytoreductive surgery and adjuvant therapy with imatinib.CONCLUSION E-GIST primary of the liver is a rare conditional,the treatment is with systemic therapy and total resection surgery.However,a cytoreductive surgery will be necessary when a complete resection is no possible. | Michel Ribeiro Fernandes Caroline Lorenzoni Almeida Ghezzi Tomaz J M Grezzana-Filho Flávia Heinz Feier Ian Leipnitz Aljamir Duarte Chedid Carlos Thadeu Schmidt Cerski Marcio Fernandes Chedid Cléber RositoPinto Kruel | 2021 | World Journal of Gastrointestinal Surgery2021，13，3： | 3 |
| 5 | Effects of resistance training on the lipid profile in obese women显示文摘 | Costa R R Lima Alberton C Tagliari M Martins Kruel L F | 2011 | Journal of Sports Medicine and Physical Fitness2011，，1： | 2 |
| 6 | Endoscopic implantation of polymethylmethacrylate augments the gastroesophageal antireflux barrier: a short-term study in a porcine model显示文摘 | C. P. F. Freitag C. R. P. Kruel M. E. S. Duarte P. R. E. Sanches P. R. O. Thomé F. Fornari D. Driemeier F. Teixeira R. O. Mollerke S. M. Callegari-Jacques S. G. S. Barros | 2009 | Surgical Endoscopy2009，，6： | 1 |
| 7 | Orthobiologics in the treatment of hip disorders显示文摘Orthobiologics are biological materials that are intended for the regeneration or healing of bone,cartilage and soft tissues.In this review we discuss the use of orthobiologics for hip disorders providing an update.The orthobiologics included in this article are hyaluronic acid,platelet rich plasma,bone marrow,adipose tissue and expanded mesenchymal stem cells.We explain the concepts and definitions of each orthobiological product,and the literature regarding its use in the hip joint.The paucity of guidelines for the production and characterization of the biological products leads to uneven results across the literature.Each biologic therapy has indications and benefits;however,noteworthy are the characterization of the orthobiologics,the application method and outcome analysis for further improvement of each technique. | Andre Vinicius Saueressig Kruel Lucas Leite Ribeiro Paulo David Gusmao Stephany Cares Huber Jose Fabio Santos Duarte Lana | 2021 | World Journal of Stem Cells2021，13，4： | 1 |
| 8 | The effect of interactive noise on the driven Brusselator model显示文摘 | Kruel Freund Schneider | | 0，，： | 1 |
| 9 | Mouse model of diethylnitrosamine - induced gastric cancer 显示文摘 | Binato M Kruel Schmidt M Silveira Volkweis B | 2008 | J Surgical Re- search2008，148，2： | 1 |
| 10 | Esophagogastric junction outflow obstruction successfully treated with laparoscopic Heller myotomy and Dor fundoplication: First case report in the literature显示文摘BACKGROUND Esophagogastric junction outflow obstruction(EGJOO) is a rare syndrome,characterized by an elevation of the integrated relaxation pressure of the lower esophageal sphincter, not accompanied by alterations in esophageal motility that may lead to the criteria for achalasia. We were unable to find any prior report of the combination of Heller myotomy with anterior partial fundoplication(Dor) as the treatment for EGJOO. We herein report a case of EGJOO treated with laparoscopic Heller myotomy combined with Dor fundoplication.CASE SUMMARY A 26-year-old man presented with a 3-year history of solid dysphagia and a 30-kg weight loss. He was treated with oral nifedipine, isosorbide, and omeprazole,without resolution of symptoms. An upper gastrointestinal series(barium swallow) revealed a 'bird's beak' sign. Esophagogastroduodenoscopy was positive for Los Angeles grade A peptic esophagitis. High-resolution esophageal manometry was compatible with EGJOO. Esophageal pH monitoring showed pathological acid reflux both in orthostatic and decubitus position. An 8-cm laparoscopic Heller myotomy combined with an anterior 220° Dor fundoplication was performed. Solid diet was introduced on postoperative day 2, and the patient was discharged home the same day. At 17-mo follow-up, he reported no symptoms. Barium swallow was compatible with complete radiologic resolution.Both esophageal manometry and upper endoscopy showed normal findings 9 mo after the operation.CONCLUSION Surgical treatment with Heller myotomy and Dor fundoplication is a potential treatment option for EGJOO refractory to medical treatment. | Pedro F Pereira Andre RP Rosa Leonardo A Mesquita Marcelle J Anzolch Rafael N Branchi Augusto L Giongo Francisco C Paix?o Marcio F Chedid Cleber DP Kruel | 2019 | World Journal of Gastrointestinal Surgery2019，11，2： | 1 |
| 11 | A review on strength exercise-induced muscle damage: applications, adaptation mechanisms and limitations显示文摘 | Brentano M A Martins Kruel L F | 2011 | Journal of Sports Medicine and Physical Fitness2011，，1： | 1 |
| 12 | Immunohisto- chemical expression of P53 and Ki-67 in diethylnitrosamine-in- duced carcinomas esophageal: experimental model显示文摘 | de Castro Junior MA Kruel CD Meurer L | 2010 | Rev Col Bras Cir2010，37，2： | 1 |
| 13 | Evaluation of the heme oxygenase-1 expression in esophagitis and esophageal can-cer induced by different reflux experimental models and diethylnitrosamine显示文摘 | Kruel CR Pinto LF Blanco TC | 2010 | Acta Cir Bras2010，25，3： | 1 |
| 14 | Transarterial Embolization for Hepatocellular Carcinoma:A Comparison between Nonspherical PVA and Mi- crospheres 显示文摘 | Leandro Armani Scaffaro Cleber Dario Pinto Kruel Steffan Fro- si Stella | 2015 | Biomed Res Int2015，，43： | 1 |
| 15 | The effect of interactive noise on the driven Brusselator model 显示文摘 | Kruel Freund Schneider | 1990 | J Chem Phys1990，93，： | 1 |
| 16 | Physiological Adaptations to Strength and Circuit Training in Postmenopausal Women With Bone Loss显示文摘 | Michel A Brentano Eduardo L Cadore Eduardo M Da Silva Anelise B Ambrosini M Coertjens Rosemary Petkowicz Itamara Viero Luiz F M Kruel | 2008 | Journal of Strength and Conditioning Research2008，，6： | 1 |
| 17 | Deep water running limits and possibilities for high performance显示文摘 | LEONARD ALEXANDRE PEYRE-TARTARUGA LUIZ FERNANDO MARTINS KRUEL | 2006 | Rev Bras Med Es- porte2006，，12： | 1 |
| 18 | The effect of interactive noise on the driven Brusselator model 显示文摘 | Kruel Freund Schneider | 1990 | J Chem Phys1990，93，： | 1 |
| 19 | Psychological Detachment from Work Dur- ing Off - job Time : The Role of Job Stressors, Job Involvement, and Recovery - related Self - efficacy 显示文摘 | Sonnentag S Kruel U | 2006 | European Journal of Work and Organizational Psychology2006，15，2： | 1 |
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