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| 1 | Clinical efficacy of the over-the-scope clip device: A systematic review显示文摘BACKGROUND The over-the-scope clip(OTSC)system has been increasingly utilized as a nonsurgical option to endoscopically manage refractory gastrointestinal(GI)hemorrhage,perforations/luminal defects and fistulas.Limited data exist evaluating the efficacy and safety of OTSC.AIM To determine the clinical success and adverse event(AE)rates of OTSC across all GI indications.METHODS A PubMed search was conducted for eligible articles describing the application of the OTSC system for any indication in the GI tract.Any article or case series reporting data for less than 5 total patients was excluded.The primary outcome was the rate of clinical success.Secondary outcomes included:Technical success rate,OTSC-related AE rate and requirement for surgical intervention despite-OTSC placement.Pooled rates(per-indication and overall)were calculated as the number of patients with the event of interest divided by the total number of patients.RESULTS A total of 85 articles met our inclusion criteria(n=3025 patients).OTSC was successfully deployed in 94.4%of patients(n=2856/3025).The overall rate of clinical success(all indications)was 78.4%(n=2371/3025).Per-indication clinical success rates were as follows:(1)86.0%(1120/1303)for GI hemorrhage;(2)85.3%(399/468)for perforation;(3)55.8%(347/622)for fistulae;(4)72.6%(284/391)for anastomotic leaks;(5)92.8%(205/221)for defect closure following endoscopic resection(e.g.,following endoscopic mucosal resection or endoscopic submucosal dissection);and(6)80.0%(16/20)for stent fixation.AE’s related to the deployment of OTSC were only reported in 64 of 85 studies(n=1942 patients),with an overall AE rate of 2.1%(n=40/1942).Salvage surgical intervention was required in 4.7%of patients(n=143/3025).CONCLUSION This systematic review demonstrates that the OTSC system is a safe and effective endoscopic therapy to manage GI hemorrhage,perforations,anastomotic leaks,defects created by endoscopic resections and for stent fixation.Clinical success in fistula management appears limited.Further studies,including randomized controlled trials comparing OTSC with conventional and/or surgical therapies,are needed to determine which indication(s)are the most effective for its use. | Nicholas Bartell Krystle Bittner Vivek Kaul Truptesh H Kothari Shivangi Kothari | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 2 | Prospective evaluation of the hemorrhoid energy treatment for the management of bleeding internal hemorrhoids显示文摘BACKGROUND The hemorrhoid energy treatment(HET)system is a non-surgical bipolar electrotherapy device,which has previously demonstrated efficacy in the management of bleeding Grade I and II internal hemorrhoids;however,data is limited.AIM To prospectively assess the safety and efficacy of the HET device.METHODS This was an IRB-approved prospective study of 73 patients with Grade I or II internal hemorrhoids who underwent HET from March 2016 to June 2019.Patient factors and procedural data were obtained.A post-procedure questionnaire was administered by telephone to all patients at 1-wk and 3-mo following HET to assess for improvement and/or resolution of rectal bleeding and adherence to a stool softener regimen.A chart review was performed to observe recurrent symptoms and durability of response.Statistical analyses were performed using SPSS software(IBM;SPSS Version 25.0).RESULTS Seventy-three patients underwent HET during the study period.Mean post-HET follow-up was 1.89 years.Complete resolution of bleeding was reported in 65%at 1 wk(n=48),with improvement in bleeding in 97.2%(n=71)of patients.At 3-mo,resolution and/or improvement in bleeding was reported in 90%(n=64)of patients.No procedure-related pain or adverse events were reported.CONCLUSION HET is well tolerated,safe and highly effective in the majority of our patients presenting with Grade I and II symptomatic internal hemorrhoids. | Truptesh H Kothari Krystle Bittner Shivangi Kothari Vivek Kaul | 2021 | World Journal of Gastrointestinal Endoscopy2021，13，8： | 2 |
| 3 | Mitochondrial uncoupling protein 2 is up-regulated in human headand neck, skin, pancreatic, and prostate tumors显示文摘 | Wenjuan Li Krystle Nichols Cherie-Ann Nathan Yunfeng Zhao | 2013 | Cancer Biomarkers2013，，5： | 2 |
| 4 | Compositional dependence of structural transition pressures in amorphous phases with mantle-related compositions显示文摘 | Sang-Heon Shim Krystle Catalli | 2009 | Earth and Planetary Science Letters2009，，1： | 1 |
| 5 | Nortel filing leaves tech sector reel- ing显示文摘 | Krystle Chow Jim Donnelly | 2009 | Ottawa Business Journal2009，14，16： | 1 |
| 6 | Spontaneous regression of mantle cell lymphoma: a report of four cases显示文摘Background:Spontaneous regression has been reported in some indolent forms of lymphoma.Mantle cell lym-phoma(MCL)is an aggressive lymphoid neoplasm and has a poor prognosis.However,approximately 30%of MCL patients can exhibit indolent clinical behavior.To date,complete spontaneous regression of MCL has not been reported.Case presentation:We describe four cases of spontaneous regression of MCL.At the time of presentation,these patients were asymptomatic,with lymph node enlargement and mild to moderate fluorodeoxyglucose(FDG)uptake on FDG-positron emission tomography combined with computed tomography.One of the possible mechanisms of spontaneous regression of the tumor could be due to the host immune response through humoral and cellular immunity,which may have a role in the clearance of tumor cells.Conclusions:In this report,we support the use of a“wait and watch”strategy for MCL patients with no risk factors and indolent behavior.This strategy helps spare patients from further potentially harmful chemotherapy.In addition,we describe the phenomenon of spontaneous regression in MCL patients who are asymptomatic and have low-volume disease. | Haige Ye Aakash Desai Tiejun Gong Dongfeng Zeng Krystle Nomie Wendy Chen Wei Wang Jorge Romaguera Michael L.Wang | 2018 | Cancer Communications2018，38，1： | 0 |
| 7 | (Re) Imagining the Intra-connections in Geography Education through the Notion of Place显示文摘One of the challenges facing geography educators at higher education institutions in South Africa is to prepare students by providing them with an integrated conceptual and pedagogical toolkit that would adequately equip them to teach a type of geography that is current and relevant to local(but also global)environmental and social phenomena.As an intra-disciplinary science,Geography offers multiple avenues for fostering this type of integration,yet as argued elsewhere,[1]because of a fragmented school Geography curriculum,teacher educators struggle to foster holistic and integrated learning among novice student teachers.In fact,academic geographers most often privilege their own field of specialisation rather than work towards integration[2].Ultimately,this perpetuates a fragmented teaching practice and conceptual understanding of geographical phenomena.This paper provides a theoretical exploration to demonstrate how Geography Education could retain its holistic nature and advance integration by(re)turning to its own intra-disciplinarity.It was found that the notion of“place”(one of Geography’s big ideas)could serve as a potential point of departure for fostering integrated thinking in the discipline.The argument is made that place-based approaches offer fertile avenues to pursue in Geography Education programmes for equipping student teachers with a holistic conceptual and pedagogical toolkit. | Krystle Ontong | 2019 | Journal of Geographical Research2019，2，2： | 0 |
| 8 | 看《飞鹰艾迪》学精彩表达显示文摘Hang on
场景回顾→Eddie从小的梦想就是拿奥运会冠军,为此他做了各种尝试。当他告诉父母,他准备放弃做泥水匠而要去德国为参加奥运会进行跳台滑雪训练时,他的父亲说道:"Hang on.What am I gonna tell your plastering teacher?(等等,那我该怎么跟你的泥水匠师傅说?)" | 吴以焕 Krystl Wiedmeier | 2016 | 新东方英语(中学版)2016，0，11： | 0 |
| 9 | How to Exercise Your Eyes显示文摘我们都知道通过去健身中心、慢跑和游泳来保持身体健康有多重要。但是,你知道吗?你也可以锻炼你的眼睛呢!眼睛锻炼将使你的眼睛保持健康并尽量减轻视疲劳。 | Krystle C. | 2012 | 英语画刊(初二版)2012，，2： | 0 |
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