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| 1 | Evaluation of quantitative contrast harmonic imaging to assess malignancy of liver tumors:A prospective controlled two-center study显示文摘AIM: To establish the extent to which contrast enhancement with SonoVue in combination with quantitative evaluation of contrast-medium dynamics facilitates the detection of hepatic tumors. METHODS: One hundred patients with histologically confirmed malignant or benign hepatic tumor (maximum size 5 cm) were analyzed. Contrast-enhanced ultrasound (bolus injection 2.5 mL SonoVue) was carried out with intermittent breath-holding technique using a multifrequency transducer (2.5-4 MHz). Native vascularization was analyzed with power Doppler. The contrast-enhanced dynamic ultrasound investigation was carried out with contrast harmonic imaging in true detection mode during the arterial,portal venous and late phases. Mechanical index was set at 0.15. Perfusion analysis was performed by post-processing of the raw data time intensity curve (TIC) analysis. The cut-off of the gray value differences between tumor and normal liver tissue was established using Receiver Operating Characteristic (ROC) analysis 64-line multi-slice computed tomography served as reference method in all cases. Magnetic resonance tomography was used additionally in 19 cases. RESULTS: One hundred patients with 59 malignant (43 colon,5 breast,2 endocrine metastases,7 hepatocellular carcinomas and 2 kidney cancers) and 41 benign (15 hemangiomas,7 focal nodular hyperplasias,5 complicated cysts,2 abscesses and 12 circumscribed fatty changes) tumors were included. The late venous phase proved to be the most sensitive for classification of the tumor type. Fifty-eight of the 59 malignant tumors were classified as true positive,and one as false negative. This resulted in a sensitivity of 98.3%. Of the 41 benign tumors,37 were classified as true negative and 4 as false negative,which corresponds to a specificity of 90.2%. Altogether,95.0% of the diagnoses were classified as correct on the basis of the histological classification. No investigator-dependency (P = 0.23) was noted. CONCLUSION: The results show the possibility of accurate prediction of malignancy of hepatic tumors with a positive prognostic value of 93.5% using advanced contrast-enhanced ultrasound. Contrast enhancement with SonoVue in combination with quantitative evaluation of contrast-medium dynamics is a valuable tool to discriminate hepatic tumors. | EM Jung DA Clevert AG Schreyer S Schmitt J Rennert R Kubale S Feuerbach F Jung | 2007 | World Journal of Gastroenterology2007，13，47： | 15 |
| 2 | Effect of preoperative biliary drainage on outcome of classical pancreaticoduodenectomy显示文摘AIM: To investigate the role of preoperative biliary drainage (PBD) in the outcome of classical pancreaticodu odenectomy. METHODS: A 10-year retrospective data analysis was performed on patients (n = 48) undergoing pancreaticoduodenectomy from March 1994 to March 2004 in department of surgery at SMS medical college, Jaipur, India. Demographic variables, details of preoperative stenting, operative procedure and post operative complications were noted. RESULTS: Preoperative biliary drainage was performed in 21 patients (43.5%). The incidence of septic complications was significantly higher in patients with biliary stent placement (P < 0.05, 0 vs 4). This group of patients also had a significantly higher minor biliary leak rate. Mortality and hospital stay in each group was comparable. CONCLUSION: Within this study population the use of PBD by endoscopic stenting was associated with a high incidence of infective complications. These findings do not support the routine use of biliary stenting in patients prior to pancreatico-duodenectomy. | Chandra Shekhar Bhati Chandrashekhar Kubal Pankaj Kumar Sihag Ankur Atal Gupta Raj Kamal Jenav Nicholas G Inston Jagdish M Mehta | 2007 | World Journal of Gastroenterology2007，13，8： | 12 |
| 3 | Fundamentals of electron beam testing of integrated circuits显示文摘 | MENZEL E KUBALED E | 1983 | Scanning1983，，5： | 2 |
| 4 | Inhibitors of apoptosis confer resistance to tumour suppression by adoptively transplanted cytotoxic T-lymphocytes in vitro and in vivo 显示文摘 | Huber C Bobek N Kuball J | 2005 | Cell Death Differ2005，12，4： | 1 |
| 5 | Essential genes on metabolic maps显示文摘 | Svetlana Gerdes Robert Edwards Michael Kubal Michael Fonstein Rick Stevens Andrei Osterman | 2006 | Current Opinion in Biotechnology2006，，5： | 1 |
| 6 | Steroid hormones, boar taint compounds, and reproductive organs in pig accord- ing to the delay between immunocastration and slaughte显示文摘 | Kubale V Batorek N Skrlep M | 2013 | Theriogenology2013，79，1： | 1 |
| 7 | Measurement of temperature in active high-power A1GaN/ GaN HFETs using raman spectroscopy 显示文摘 | Kuball M Hayes J M Uren M J | 2002 | IEEE Electron Device Letters2002，23，1： | 1 |
| 8 | Activation-induced expression of CD137 permits detection, isolation, and expansion of the full repertoire of CD8 T cells responding to antigen without requiring knowledge of epitope specificities 显示文摘 | Wolff M Kuball J Ho WY | 2007 | Blood2007，110，1： | 1 |
| 9 | A simple procedure for the long term cultivation of chicken embroy 显示文摘 | Auerbach R Kubal L | 1974 | Dev Biol1974，11，： | 1 |
| 10 | A simple procedure for the long- term cultivation of chicken embryos显示文摘 | Kubal L Knighton D | 1974 | Dev Biol1974，41，2： | 1 |
| 11 | Imaging of orbital trauma 显示文摘 | Kubal WS | 2008 | Radiographics2008，28，： | 1 |
| 12 | Surface raman spectroscopy of GaN,AlGaN and AlN for process and growth minitoring/control显示文摘 | Kubal M | 2001 | Interface Anal2001，31，： | 1 |
| 13 | Raman Spectroscopy of GaN, AlGaN and AlN for Process and Growth Monitoring Control 显示文摘 | Kuball M | 2001 | Surface and Interface Analysis2001，31，10： | 1 |
| 14 | Gadolinium-enhanced magnetic resonance imaging of the facial nerve in herpes zoster oticus and Bell,s palsy:clinical implications显示文摘 | Korzec K Sobol SM Kubal W | 1991 | Am J Otol1991，12，3： | 1 |
| 15 | Critical level of oxygen delivery in anesthetized man显示文摘 | Shibutani K Komatsu T Kubal K | 1983 | Crit Care Med1983，11，8： | 1 |
| 16 | Blockade of PD-L1 ( B7-H1 ) augments human tumor-specific T cell responses in vitro显示文摘 | Blank C Kuball J Voelkl S | 2006 | Int J Cancer2006，119，2： | 1 |
| 17 | Multivisceral Transplantation for Diffuse Portomesenteric Thrombosis显示文摘 | Rodrigo M. Vianna Richard S. Mangus Chandrashekhar Kubal Jonathan A. Fridell Thiago Beduschi A. Joseph Tector | 2012 | Annals of Surgery2012，，6： | 1 |
| 18 | Imaging of orbital trauma显示文摘 | Kubal WS | | 0，，06： | 1 |
| 19 | Measurement of temperature in active high-power AIGaN/GaN HFETs u- sing Raman spectroscopy 显示文摘 | Kuball M Hayes J M Uren M J | 2002 | Electron Device Letters IEEE2002，23，1： | 1 |
| 20 | Nitric Oxide Promotes Resistance to Tumor Suppression by CTLs显示文摘 | Su Z Kuball J Barreiros AP | 2006 | Journal of Immunology2006，176，7： | 1 |
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