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| 1 | Video capsule endoscopy vs double-balloon enteroscopy in the diagnosis of small bowel bleeding:A systematic review and metaanalysis显示文摘AIM To compare the diagnostic accuracy of video capsule endoscopy(VCE) and double-balloon enteroscopy(DBE) in cases of obscure gastrointestinal bleeding(OGIB) of vascular origin.METHODS MEDLINE(via PubMed), LILACS(via BVS) and Cochrane/CENTRAL virtual databases were searched for studies dated before 2017. We identified prospective and retrospective studies, including observational, cohort, single-blinded and multicenter studies, comparing VCE and DBE for the diagnosis of OGIB, and data of all the vascular sources of bleeding were collected. All patients were subjected to the same gold standard method. Relevant data were then extracted from each included study using a standardized extraction form. We calculated study variables(sensitivity, specificity, prevalence, positive and negative predictive values and accuracy) and performed a meta-analysis using Meta-Disc software.RESULTS In the per-patient analysis, 17 studies(1477 lesions) were included. We identified3150 exams(1722 VCE and 1428 DBE) in 2043 patients and identified 2248 sources of bleeding, 1467 of which were from vascular lesions. Of these lesions, 864(58.5%) were diagnosed by VCE, and 613(41.5%) were diagnosed by DBE. The pretest probability for bleeding of vascular origin was 54.34%. The sensitivity of DBE was 84%(95%CI: 0.82-0.86; heterogeneity: 78.00%), and the specificity was92%(95%CI: 0.89-0.94; heterogeneity: 92.0%). For DBE, the positive likelihood ratio was 11.29(95%CI: 4.83-26.40; heterogeneity: 91.6%), and the negative likelihood ratio was 0.20(95%CI: 0.15-0.27; heterogeneity: 67.3%). Performing DBE after CE increased the diagnostic yield of vascular lesion by 7%, from 83% to90%.CONCLUSION The diagnostic accuracy of detecting small bowel bleeding from a vascular source is increased with the use of an isolated video capsule endoscope compared with isolated DBE. However, concomitant use increases the detection rate of the bleeding source. | Hélcio Pedrosa Brito Igor Braga Ribeiro Diogo Turiani Hourneaux de Moura Wanderley Marques Bernardo Dalton Marques Chaves Rogério Kuga Ethan Dwane Maahs Robson Kiyoshi Ishida Eduardo Turiani Hourneaux de Moura Eduardo Guimaraes Hourneaux de Moura | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，12： | 10 |
| 2 | Plasmid-encoded metallo-beta-lactamase(IMP-6) conferring resistance to carbapenems, especially meropenem显示文摘 | Yano H Kuga A Okamoto R | 2001 | Antimicrob Agents Chemother2001，45，： | 1 |
| 3 | Mechanisms ofcarbon dioxide gas adsorption by grains and its applica-tion to skin-packaging显示文摘 | Mitsuda H Kawai F Kuga M | 1973 | Journal of Nutritional Sci-ence and Vitaminology1973，19，1： | 1 |
| 4 | Systematic research of peptide spacers controlling drug release from macromolecular prodrug system,carboxymethyldextran polyalcohol-peptide-drug conjugates显示文摘 | Shiose Y Kuga H Ohki H | | 0，，01： | 1 |
| 5 | Effect of IL-17 on ICAM-1 expression of human bronchial epithelial cells, NCI-H 292显示文摘 | Kawaguchi M Kokubu F Kuga H | 1999 | Arerugi1999，48，10： | 1 |
| 6 | Magnetite nanoparticle-loaded anti-HER2 immunoliposomes for combination of antibody therapy with hyperthermia显示文摘 | Ito A Kuga Y Honda H Kikkawa H Horiuchi A Watanabe Y Kobayashi T | 2004 | Cancer Letters2004，212，2： | 1 |
| 7 | Presence of genes for β-lactamases of two different classes on a single plasmid from a clinical isolates of Serratia marcescens 显示文摘 | Yano H Kuga A Irinoda K | 1999 | J Antibiot (Tokyo)1999，52，： | 1 |
| 8 | Platelet function and spontaneous thrombolytic activity of patients with cerebral infarction assessed by the global thrombosis test显示文摘 | Taomoto K Ohnishi H Kuga Y | 2010 | Pathophysiol Haemost Thromb2010，37，1： | 1 |
| 9 | Administration of atrial natriuretic peptide attenuates reperfusion phenomena and preserves left ventricular regional wall motion after direct coronary angioplasty for acute myocardial infarction显示文摘 | Kuga H Ogawa K | 2003 | Circ J2003，67，3： | 1 |
| 10 | Presence of genes for β-lactam ases of two d ifferent classes on a single plasmid from a clinical isolates of Serratia marces cens显示文摘 | Yano H Kuga A Irinoda K | 1999 | J Antibiot1999，52，12： | 1 |
| 11 | Comparison between two methods to calcu- late the transition matrix of orbit motion 显示文摘 | CHIARADIA A P M KUGA H K PRADO A F B A | 2012 | Mathematical Problems in Engineering2012，，： | 1 |
| 12 | Grinding characteristics of bromine-exfoliated graphite and natural graphite显示文摘 | Endoh S Chiyoda H | 1990 | Powder Technol1990，60，： | 1 |
| 13 | Modulation ofbronchial epithelial cells by IL-17 显示文摘 | Kawaguchi M Kokubu F Kuga H | 2001 | J Allergy ClinImmunol2001，108，： | 1 |
| 14 | Presence of genes for betalactamases of two different classes on a single plasmid from a clinical isolate of Serratia marcescens 显示文摘 | Yano H Kuga A Irinoda K | 1999 | J Antibiot ( Tokyo )1999，52，12： | 1 |
| 15 | Administration of atrial natriuretic peptide attenutes reperfusion phenomena and preserves left ventricular wall motion after direct coronary angioplasty for acute myocardial infarction 显示文摘 | Kuga H Ogawa K Oida A | 2003 | Circ J2003，67，5： | 1 |
| 16 | Plasmid-encoded metallo-beta-lactamase (IMP-6) conferring resistance to carbapenems, especially meropenem 显示文摘 | Yano H Kuga A Okamoto R | 2001 | Antimicrob Agents Chemother2001，45，5： | 1 |
| 17 | A Notch-wire Composite Antenna for Polarization Diversity Reception显示文摘 | KUGA N ARAI H GOTO N | 1998 | IEEE Transitions on Antennas and Propagation1998，46，6： | 1 |
| 18 | Plasmid-encoded metallo-beta-lactamase (IMP-6) conferring resistance to carbapenems, especially meropenem显示文摘 | Yano H Kuga A Okamoto R | 2001 | Antimicrob Agents Chemother2001，45，5： | 1 |
| 19 | A possible mechanism for the long-lasting antitumor effect of the macromolecuLar conjugate DE-310: mediation by cellular uptake and drug release of its ac- tive camptothecin analog DX-8951 显示文摘 | OCHI Y SHIOSE Y KUGA H | 2005 | Cancer Chemother Phar- macol2005，55，4： | 1 |
| 20 | Presence of genes for β-lactamases of two different classes on a single plasmid from a clinical isolates of Serratia marcescens显示文摘 | Yano H Kuga A Irinoda K | 2000 | J Antibiot (Tokyo)2000，52，12： | 1 |
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