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| 1 | Error-prone PCR of a fungal xylanase for improvement of its alkaline and thermal stability显示文摘 | DAWN E S SUREN S KUGEN P | 2009 | FEMS Microbiology Letters2009，293，1： | 1 |
| 2 | Distribution profiles ofmembrane type-1 matrix-metalloproteinase(MT1-MMP),ma-trixmetalloproteinase-2(MMP-2)and cyclo-oxygenase-2(COX-2)in rabbit atherosclerosis:comparison with plaque insta-bility analysis显示文摘 | KUGEN Y TAKAI N ISHINO S | 2007 | Biol Pharm Bul l2007，30，9： | 1 |
| 3 | Chemical shift magnetic resonance spectroscopy of cingulate grey matter in patients with minimal hepatic encephalopathy显示文摘 | Sergei Mechtcheriakov Michael Schocke André Kugener Ivo W. Graziadei Michael Mattedi Hartmann Hinterhuber Wolfgang Vogel Josef Marksteiner | 2005 | Neuroradiology2005，，1： | 1 |
| 4 | Chemical shift magnetic resonance spectroscopy of cingnlated grey matter in patients with minimal hepatic encephalopathy 显示文摘 | Mechtcheriakov S Schocke M Kugener A | 2005 | Neuroradiology2005，47，： | 1 |
| 5 | Multidimensional assessment of neuro-psychiatric symptoms in patients with low-grade hepatic encephalopathy: A clinical rating scale显示文摘AIM: To evaluate the feasibility of a new clinical rating scale for a standardized assessment of cirrhosis-associated neuro-psychiatric symptoms.METHODS: Forty patients with liver cirrhosis (LC, with or without low-grade hepatic encephalopathy) were invest-igated using a clinical neuro-psychiatric rating scale based on a comprehensive list of neurological, psychomotor,cognitive, affective, behavioral symptoms, and symptoms of disturbed bioregulation.RESULTS: The analysis revealed that the majority of cirrhotic patients showed, besides characteristic neurological symptoms of hepatic encephalopathy, various psychomotor,affective and bioregulatory symptoms (disturbed sleep and sexual dysfunction). Patients were impaired in the following subscales: sleep and biorhythm disorder (75.0% of patients), Parkinsonoid symptoms (25.0%), affective symptoms (17.5%), and psychomotor retardation (12.5%).The increase of total neuro-psychiatric clinical score was significantly associated with the degree of hepatic enceph-alopathy.CONCLUSION: This study suggests that a substantial number of patients with LC and low-grade hepatic encephalopathy manifest various clinical neuro-psychiatric symptoms. The use of a rating scale, which explores clinical dimensions of hepatic encephalopathy, would improve the management of patients with LC. | Sergei Mechtcheriakov Ivo W Graziadei André Kugener Julia Wiedemann Chantal Galbavy Hartmann Hinterhuber Josef Marksteiner Wolfgang Vogel | 2005 | World Journal of Gastroenterology2005，11，37： | 1 |
| 6 | Supplemental Oxygen, but Not Supplemental Crystalloid Fluid, Increases Tissue Oxygen Tension in Healthy and Anastomotic Colon in Pigs显示文摘 | Oliver Kimberger Edith Fleischmann Sebastian Brandt André Kugener Barbara Kabon Luzius Hiltebrand Vladimir Krejci Andrea Kurz | 2007 | Anesthesia & Analgesia2007，，3： | 1 |
| 7 | Chemical shift magnetic resonance spectroscopy of cingulated grey matter in patients with minimal hepatic encephalopathy显示文摘 | Mechtcheriakov S Schocke M Kugener A | 2005 | Neuroradiology2005，47，1： | 1 |
| 8 | DESIGN OF A MOBILE TELEMEDICINE SYSTEM WITH WIRELESS LAN显示文摘 | Kugen C Krishnan SM Chutatape O | 2002 | IEEE:Circuits and Systems2002，，： | 1 |
| 9 | Chemical shift magnetic resonance spectroscopy of cingulated grey matter in patients with minimal hepatic encephalopathy显示文摘 | Mechtcheriakov S Schocke M Kugener A | 2005 | Neuroradiology2005，47，： | 1 |
| 10 | Chemical Shift Magnetic Resonance Spectroscopy of Cingulated Grey Matter in Patients with Minimal Hepatic Encephalopathy显示文摘 | Mechtcheriakov S Schoeke M Kugener A | 2005 | Neuroradiology2005，47，1： | 1 |
| 11 | Human parechovirus infec- tions, Lyon, France, 2008-10: evidence for severe cases 显示文摘 | Schuffenecker I Javouhey E Gillet Y Kugener B Billaud G Floret D Lina B Morfin F | 2012 | J Clin Virol2012，54，4： | 1 |
| 12 | 普鲁兰酶N467G突变体的酶学性质分析显示文摘在淀粉制糖工业中,普鲁兰酶通常与糖化酶配合使用,其在酸性pH和较高温度下的催化活力是影响淀粉脱支效率的主要因素。该研究通过对长野芽胞杆菌(Bacillus naganoensis)普鲁兰酶蛋白质解折叠自由能的差值(ΔΔG)的计算预测和突变位点稳定性分析,选择突变位点并进行定点突变,获得突变体N467G。与野生型普鲁兰酶分子相比,突变体N467G的最适作用温度提高至60℃,最适作用pH降低至4.5;其在60℃条件下孵育2.5 h或在pH 3.5~5.5孵育1 h残留酶活力均保持在80%以上,稳定性明显提高。此突变体的获得为其后续高效表达与工业化应用奠定了重要基础。 | 张亚楠 申培立 牛丹丹 田康明 KUGEN PERMAUL SUREN SINGH 王正祥 | 2021 | 食品与发酵工业2021，47，5： | 1 |
| 13 | Chemical shift magnetic resonance spectroscopy of cingulated grey matter in patients with minimal hepatic encephalopathy显示文摘 | Mechtcheriakov S Schocke M Kugener A | 2005 | Neuroradiology2005，47，1： | 1 |
| 14 | 对SAFE-T结肠镜评估工具(通过基于网络的智能手机应用程序评估胃肠专科医生结肠镜培训效果)的多中心前瞻性验证显示文摘Introduction One of the key objectives of gastroenterology(GI)fellowships is to teach fellows how to perform high-quality endoscopic procedures[1].The primary model for this education is the apprenticeship approach,in which fellows perform endoscopic procedures on patients under the supervision of an attending gastroenterologist[2].Critical to the success of this teaching model,faculty should deliver timely and actionable feedback based on direct observation of the fellow’s endoscopic performance[3]. | Navin L.Kumar Guillaume Kugener Abhinav Vemula Sharmeel K.Wasan Amiko Uchida Fabian J.Scheid Joseph Yarze John R.Saltzman | 2021 | Gastroenterology Report2021，9，2： | 0 |
| 15 | 基于网络的上消化道内镜SAFE-T工具:实时评估胃肠专科医生内镜培训效果显示文摘背景:导师评估是胃肠专科医生内镜培训的一个关键部分。本研究旨在建立和验证一个简明的、基于网络的上消化道内镜培训效果实时评估工具。方法:我们建立了针对上消化道内镜的专科医生内镜培训技能评估(SAFE-T)工具,在一个5部分的问卷中获取总结性和格式化的反馈。该工具与既往已获验证的结肠镜SAFE-T相似,是基于网络开展应用的。我们应用该工具对2018-2019学年的15名胃肠专科医生(培训期1、2、3年各5名)。为确保评估的可靠性,由一名独立评审人对不同的上消化道内镜操作技术进行评估,完成SAFE-T和内镜能力评估(ACE)两份量表。结果:20名高年资医生在研究期间对15名专科医生进行了413次SAFE-T评估。不同培训学年的专科医生平均SAFE-T评分存在显著差异,第一学年医生的评分低于第二学年(3.31 vs 4.25,P<0.001),第二学年低于第三学年(4.25 vs 4.56,P<0.001)。随着内镜操作难度的增加,平均SAFE-T评分下降,简单操作的评分高于中等操作(3.98 vs 3.39,P<0.001),中等操作高于困难操作(3.39 vs 2.84,P=0.042)。导师与独立评审人同时观察评估一项内镜操作,其SAFE-T评分一致性良好(Kappa=0.815,P=0.001)。SAFE-T评分与ACE评分高度相关(r=0.76,P=0.011)。结论:我们建立并验证了SAFE-T这种简明的、基于网络的工具,用以实时评估胃肠专科医生上消化道内镜培训效果的有效性。 | Navin L.Kumar Guillaume Kugener Kelly E.Hathorn Molly L.Perencevich Kunal Jajoo John R.Saltzman | 2020 | Gastroenterology Report2020，8，6： | 0 |
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