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| 1 | Glutamate receptors and glutamatergic signalling in the peripheral nerves显示文摘In the peripheral nervous system,the vast majority of axons are accommodated within the fibre bundles that constitute the peripheral nerves.Axons within the nerves are in close contact with myelinating glia,the Schwann cells that are ideally placed to respond to,and possibly shape,axonal activity.The mechanisms of intercellular communication in the peripheral nerves may involve direct contact between the cells,as well as signalling via diffusible substances.Neurotransmitter glutamate has been proposed as a candidate extracellular molecule mediating the cross-talk between cells in the peripheral nerves.Two types of experimental findings support this idea:first,glutamate has been detected in the nerves and can be released upon electrical or chemical stimulation of the nerves;second,axons and Schwann cells in the peripheral nerves express glutamate receptors.Yet,the studies providing direct experimental evidence that intercellular glutamatergic signalling takes place in the peripheral nerves during physiological or pathological conditions are largely missing.Remarkably,in the central nervous system,axons and myelinating glia are involved in glutamatergic signalling.This signalling occurs via different mechanisms,the most intriguing of which is fast synaptic communication between axons and oligodendrocyte precursor cells.Glutamate receptors and/or synaptic axon-glia signalling are involved in regulation of proliferation,migration,and differentiation of oligodendrocyte precursor cells,survival of oligodendrocytes,and re-myelination of axons after damage.Does synaptic signalling exist between axons and Schwann cells in the peripheral nerves?What is the functional role of glutamate receptors in the peripheral nerves?Is activation of glutamate receptors in the nerves beneficial or harmful during diseases?In this review,we summarise the limited information regarding glutamate release and glutamate receptors in the peripheral nerves and speculate about possible mechanisms of glutamatergic signalling in the nerves.We highlight the necessity of further research on this topic because it should help to understand the mechanisms of peripheral nervous system development and nerve regeneration during diseases. | Ting-Jiun Chen Maria Kukley | 2020 | Neural Regeneration Research2020，15，3： | 4 |
| 2 | Carnosine protects rats under global ischemia显示文摘 | Stvolinsky S Kukley M Dobrota D | 2000 | Brain Res Bull2000，53，4： | 1 |
| 3 | Firing pattern and calbindin- D28k content of human epileptic granule cells 显示文摘 | Selke K Mailer A Kukley M | 2006 | Brain Res2006，1120，： | 1 |
| 4 | Glial cells are born with synapses 显示文摘 | Kukley M Kiladze M Tognatta R | | FASEB J0，22，： | 1 |
| 5 | The fate of synaptic input to NG2 glial ceils: neurons specifically downregulate transmitter re- lease onto differentiating oligodendroglial cells 显示文摘 | Kukley M Nishiyama A Dietrich D | 2010 | J Neurosci2010，30，： | 1 |
| 6 | Vesicular glutamate re- lease from axons in white matter 显示文摘 | Kukley M Capetillo-Zarate E Dietrich D | 2007 | Nat Neurosci2007，10，： | 1 |
| 7 | Kainate receptors and signal integration by NG2 glial cells 显示文摘 | Kukley M Dietrich D | 2009 | Neuron Glia Biol2009，5，： | 1 |
| 8 | Carnosine protects rats under global ischemia显示文摘 | Stvolinsky S Kukley M Dobrota D | 2000 | Brain Res Bull2000，53，4： | 1 |
| 9 | Carnosine protects rats under global ischemia显示文摘 | KUKLEY M DOBROTA D | 2000 | Brain Res Bull2000，53，4： | 1 |
| 10 | Distribution of P2X recptors on astrocytes in juvenile rat hippocampus显示文摘 | Kukley M Barden JA Steinhauser C | 2001 | Glia2001，36，1： | 1 |
| 11 | Carnosine protects rats under global ischemia显示文摘 | Stvolinsky S Kukley M Dobrota D | | 0，，04： | 1 |
| 12 | Effect of carnosine on rats under experimental brain ischemia 显示文摘 | GALLANT S KUKLEY M STVOLINSKY S | 2000 | Tohoku J Exp Med2000，191，2： | 1 |
| 13 | Carnosine:an endogenous neuroprotector in the ischemic brain显示文摘 | KUKLEY M L DOBROTA D | 1999 | Cell Mol Neurobiol1999，19，1： | 1 |
| 14 | Carnosine protects rats under global ischemia显示文摘 | STVOLINSKY S KUKLEY M DOBROTA D er al | 2000 | Brain Research Bulletin2000，53，4： | 1 |
| 15 | Effect of 5-hydroxytryptamine1A receptor agonist BAY X 3702 on BCL-2 and BAX proteins level in the ipsilateral cerebral cortex of rats after transient focal ischaemia显示文摘 | Kukley M Schaper C Becker A | 2001 | Neuroscience2001，107，： | 1 |
| 16 | Effect of carnosine on rats under experimental brain ischemia显示文摘 | Gallant S Kukley M Stvolinsky S | | 0，，02： | 1 |
| 17 | The fate of synaptic input to NG2 glial cells: neurons specifically downregulate transmitter release onto differentiating oligodendroglial cells 显示文摘 | Kukley M Nishiyama A Dietrich D | 2010 | J Neurosci2010，30，24： | 1 |
| 18 | Vesicular glutamate release from axons in white matter显示文摘 | Kukley M Capetillo-Zarate E Dietrich D | 2007 | Nat Neurosci2007，10，3： | 1 |
| 19 | Vesicular glutamate release from axons in white matter显示文摘 | Kukley M Capetillo-Zarate E Dietrich D | 2007 | Nat Neurosci2007，10，3： | 1 |
| 20 | Carnosine protects rats under global ischemia显示文摘 | STVOLINSKY S KUKLEY M DOBROTA D | 2000 | Brain Res Bull2000，53，4： | 1 |
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