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| 1 | Valproic acid teratogenicity: A toxicogenomics approach 显示文摘 | Kultima K Nystrom A M Scholz B | 2004 | Environ Health Perspect2004，112，12： | 1 |
| 2 | Exposure to brominated flame retardant PBDE-99 affects cytoskeletal protein expression in the neonatal mouse cerebral cortex 显示文摘 | Aim H Kultima K Scholz B | 2008 | Neurotoxicology2008，29，4： | 1 |
| 3 | Exposure to brominat-ed flame retardant PBDE-99 affects cytoskeletal protein ex-pression in the neonatal mouse cerebral cortex显示文摘 | Alm H Kultima K Scholz B | 2008 | Neurotox-icology2008，29，4： | 1 |
| 4 | Altered levels of CSF proteins in patients with FTD, presymptomatic mutation carriers and non-carriers显示文摘Background The clinical presentations of frontotemporal dementia(FTD)are diverse and overlap with other neurological disorders.There are,as of today,no biomarkers in clinical practice for diagnosing the disorders.Here,we aimed to find protein markers in cerebrospinal fluid(CSF)from patients with FTD,presymptomatic mutation carriers and non-carriers.Methods Antibody suspension bead arrays were used to analyse 328 proteins in CSF from patients with behavioural variant FTD(bvFTD,n=16)and progressive primary aphasia(PPA,n=13),as well as presymptomatic mutation carriers(PMC,n=16)and non-carriers(NC,n=8).A total of 492 antibodies were used to measure protein levels by direct labelling of the CSF samples.The findings were further examined in an independent cohort including 13 FTD patients,79 patients with Alzheimer’s disease and 18 healthy controls.Results We found significantly altered protein levels in CSF from FTD patients compared to unaffected individuals(PMC and NC)for 26 proteins.The analysis show patterns of separation between unaffected individuals and FTD patients,especially for those with a clinical diagnosis of bvFTD.The most statistically significant differences in protein levels were found for VGF,TN-R,NPTXR,TMEM132D,PDYN and NF-M.Patients with FTD were found to have higher levels of TN-R and NF-M,and lower levels of VGF,NPTXR,TMEM132D and PDYN,compared to unaffected individuals.The main findings were reproduced in the independent cohort.Conclusion In this pilot study,we show a separation of FTD patients from unaffected individuals based on protein levels in CSF.Further investigation is required to explore the CSF profiles in larger cohorts,but the results presented here has the potential to enable future clinical utilization of these potential biomarkers within FTD. | Julia Remnestål Linn Oijerstedt Abbe Ullgren Jennie Olofsson Sofia Bergström Kim Kultima Martin Ingelsson Lena Kilander Mathias Uhlén Anna Månberg Caroline Graff Peter Nilsson | 2020 | Translational Neurodegeneration2020，9，2： | 1 |
| 5 | Cadmium-induced gene expression changes in the mouse embryo, and the influence of prelrealment with zinc显示文摘 | Kultima K Fem ndez EL Scholz B | 2006 | Reproduc Toxicol:2006，22，4： | 1 |
| 6 | Neuropeptidomic analysis of the embryonic Japanese quail diencephalon显示文摘 | Scholz B Alm H Mattsson A Nilsson A Kultima K Savitski M M F(a)lth M Sk(o)ld K Brunstr(o)m B Andren P E Dencker L | | 0，，01： | 1 |
| 7 | Molecular targets and early response biomarkers for the prediction of developmental toxicity in vitro 显示文摘 | STIGSON M KULTIMA K JERGIL M | 2007 | Altern Lab Anim2007，35，3： | 1 |
| 8 | Exposure to brominated flame retardant PBDE-99 affects cytoskeletal protein expression in the neo- natal mouse cerebral cortex显示文摘 | Alm H Kultima K Scholz B | 2008 | Neurotoxicology2008，29，4： | 1 |
| 9 | Valproic acid teratogenicity:a toxicogenomics approach显示文摘 | Kultima K Nystrm AM Scholz B | 2004 | Environ Health Persp2004，112，12： | 1 |
| 10 | Pc5 Oscillation Analysis by the Satellite and Ground-Based Data显示文摘Large amplitude Pc5 event was observed in the space and on ground on August 3, 2001, about three hours after contact of the strong discontinuity in the solar wind with the magnetosphere according to data from ACE and Wind satellites. The Pc5 amplitude was as high as 15 nT in the tail of magnetosphere and about 5 nT at the ground based stations. In the magnetosphere Pc5 waves were observed by Cluster and Polar satellites, which occupied positions in the morning part of the near tail at the close field lines but were parted by distance of 11.5 Re, mainly along the x-axis of the GSM coordinate system. Both compressional and transverse components of the Pc5 wave activity were observed in the space, with the transverse component having the larger amplitude. Time delay between the Cluster and Polar satellites was about 8 minutes, which could be interpreted as a wave propagation from the geomagnetic tail to the Earth with the 150km/s group velocity.The ground-based Pc5 activity was analysed by using data from the Image magnetometer network. Doubtless demonstrations of a field line resonant structure were found in variations of amplitude and polarization with latitude. Finnish chain of search coil magnetometers observed modulated Pc1 emission simultaneously with the Pc5 wave train. A possibility of non-linear impact of Pc5 wave energy on the plasma and waves in the magnetosphere is discussed. | A. Potapov T. Polyushkina T. L. Zhang H. Zhao A. Guglielmi J. Kultima | 2005 | 空间科学学报2005，25，5： | 0 |
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