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| 1 | Assessment of source water contamination by estrogenic disrupting compounds in China显示文摘Detection of estrogenic disrupting compounds(EDCs) in drinking waters around China has led to rising concerns about health risks associated with these compounds.There is,however,a paucity of studies on the occurrence and identification of the main compounds responsible for this pollution in the source waters.To fill this void,we screened estrogenic activities of 23 source water samples from six main river systems in China,using a recombinant two-hybrid yeast assay.All sample extracts induced significant estrogenic activity,with E2 equivalents(EEQ) of raw water ranging from 0.08 to 2.40 ng/L.Additionally,16 samples were selected for chemical analysis by gas chromatography-mass spectrometry.The EDCs of most concern,including estrone(E1),17β-estradiol(E2),17α-ethinylestradiol(EE2),estriol(E3),diethylstilbestrol(DES),estradiol valerate(EV),4-t-octylphenol(4-t-OP),4-nonylphenols(4-NP) and bisphenol A(BPA),were determined at concentrations of up to 2.98,1.07,2.67,4.37,2.52,1.96,89.52,280.19 and 710.65 ng/L,respectively.Causality analysis,involving comparison of EEQ values from yeast assay and chemical analysis identified E2,EE2 and 4-NP as the main responsible compounds,accounting for the whole estrogenic activities(39.74% to 96.68%).The proposed approach using both chemical analysis and yeast assay could be used for the identification and evaluation of EDCs in source waters of China. | Weiwei Jiang YeYan Mei Ma Donghong Wang Qian Luo Zijian Wang Senthil Kumaran Satyanarayanan | 2012 | Journal of Environmental Sciences2012，24，2： | 29 |
| 2 | In vitro antioxidant activities of methanol extracts of five Phyllanthus species from India显示文摘 | A. Kumaran R. Joel Karunakaran | 2005 | LWT - Food Science and Technology2005，，2： | 5 |
| 3 | Retinoid X receptor activities of source waters in China and their removal efficiencies during drinking water treatment processes显示文摘There is increasing evidence of estrogenic activities of source waters and drinking waters in China based on estrogen receptors(ERs) testing.However,relating such activities to retinoid X receptors(RXRs) in both drinking and source waters are lacking.To rectify this situation,we assessed 23 source water samples from six major river systems in China.We also collected samples at various stages of water processing from three drinking water treatment plants(DWTPs) using a two-hybrid RXR yeast assay with and without metabolism.No RXR agonistic activity was observed,but significant antagonistic activity was detected in all sample extracts.The RXR antagonistic activities of source water sample extracts ranged from 15.2% to 57.8% without metabolism and 11.5% to 68.3% with metabolism,respectively.In the drinking water treatment processes,RXR antagonistic activities without metabolism and with metabolism of up to 31.4% and 37.5% were removed,respectively.Nevertheless,the remaining RXR antagonists in treated drinking water from these source waters could still be harmful to human health.To the best of our knowledge,the occurrence of in vitro RXR disruption activities in source and drinking water has not been previously reported in China.Therefore,an attempt was made to conduct detailed studies investigating RXR disrupting activities and their possible risks in source and drinking water. | JIANG WeiWei YAN Ye LI Na MA Mei WANG DongHong RAO KaiFeng WANG ZiJian SATYANARAYANAN Senthi Kumaran | 2012 | Chinese Science Bulletin2012，57，6： | 5 |
| 4 | Antioxidant and free radical scavenging activity of an aqueous extract of Coleus aromaticus显示文摘 | A. Kumaran R. Joel karunakaran | 2005 | Food Chemistry2005，，1： | 3 |
| 5 | PID Controller Tuning for a Multivariable Glass Furnace Process by Genetic Algorithm显示文摘Standard genetic algorithms(SGAs) are investigated to optimise discrete-time proportional-integral-derivative(PID) controller parameters, by three tuning approaches, for a multivariable glass furnace process with loop interaction. Initially, standard genetic algorithms(SGAs) are used to identify control oriented models of the plant which are subsequently used for controller optimisation. An individual tuning approach without loop interaction is considered first to categorise the genetic operators, cost functions and improve searching boundaries to attain the desired performance criteria. The second tuning approach considers controller parameters optimisation with loop interaction and individual cost functions. While, the third tuning approach utilises a modified cost function which includes the total effect of both controlled variables, glass temperature and excess oxygen. This modified cost function is shown to exhibit improved control robustness and disturbance rejection under loop interaction. | Kumaran Rajarathinam James Barry Gomm Ding-Li Yu Ahmed Saad Abdelhadi | 2016 | International Journal of Automation and computing2016，13，1： | 3 |
| 6 | Antibacterial potential of sponge endosymbiont marine Enterobacter sp at Kavaratti Island,Lakshadweep archipelago显示文摘Objective:To isolate antibacterial potential of sponge endosymbiotic bacteria from marine sponges at Lakshadweep archipelago.Also to identify the potent bacteria by 16s rDNA sequencing and determine the antibacterial activity against clinical pathogens by MIC.Methods: Sponge samples was collected from sub-tidal habitats at Kavaratti Island and identified.The endosymbiotic bacteria were isolated and selected potential bacteria which show antibacterial activity in preliminary screening against clinical pathogens Staphylococcus aureus(S.aureus), Escherichia coli(E.coli),Salmonella typhi(S.typhi),Klebsiella pneumoniea(K.pneumoniea) and Streptococcus sp.by disc diffusion assay.The crude extracts of potential bacteria LB3 was tested against clinical pathogens by MIC.The LB3 strain was identified by 16s rDNA sequencing, 1111 bp was submitted in NCBI(HQ589912) and constructed phylogenetic tree.Results:Sponge sample was identified as Dysidea granulosa(D.granulosa) and potential bacteria LB3 identified as Enterobacter sp TTAG.Preliminary screening of sponge isolates against clinical pathogens,LB3 strain was selected as potential producer of secondary metabolites and crude extract was implies on MIC of LB3 have confirmed with lowest concentration of 5.0 mg/mL in broth medium influence of crude extract on growth inhibitory activity after 5 h of incubation period and completed the inhibitory activity at 15 h.Conclusions:The present study concluded that phylogenetic analysis of endosymbiotic bacteria Enterobacter sp from sponge D.granulosa of Lakshadweep islands showed significant antibacterial activity against clinical bacterial pathogens. | Mohan Gopi Subramanian Kumaran Thipparamalai Thangappanpillai Ajith Kumar Balaraman Deivasigamani Kumarappan Alagappan Srinivasan Guru Prasad | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，2： | 2 |
| 7 | Hepatic Artery Pseudoaneurysms: A Single-Center Experience显示文摘 | Raghavendra Nagaraja Mahendran Govindasamy Vibha Varma Amitabh Yadav Naimish Mehta Vinay Kumaran Arun Gupta Samiran Nundy | 2013 | Annals of Vascular Surgery2013，，6： | 2 |
| 8 | In vitro anti- Helicobacter pylori activity of a flavonoid rich extract of Glycyrrhiza glabra and its probable mechanisms of action显示文摘 | Mannanthendil Kumaran Asha Debnath Debraj D’souza Prashanth Jothie Richard Edwin H.S. Srikanth Nithyanantham Muruganantham Shekhar Michael Dethe Bhaskar Anirban Balachandran Jaya Mundkinajeddu Deepak Amit Agarwal | 2012 | Journal of Ethnopharmacology2012，，： | 2 |
| 9 | Isolation and characterization of Pseudomonas sp. KUMS3 from Asian sea bass (Lates calcarifer) with fin rot显示文摘 | S. Kumaran B. Deivasigamani K. M. Alagappan M. Sakthivel S. Guru Prasad | 2010 | World Journal of Microbiology and Biotechnology2010，，2： | 2 |
| 10 | In vitro antioxidant activities of methanol extracts of five Phyllanthus species from India显示文摘 | A. Kumaran R. Joel Karunakaran | 2005 | LWT - Food Science and Technology2005，，2： | 2 |
| 11 | 客车薄侧板电弧焊变形和矫正的有限元模拟显示文摘铁路客车车厢薄侧板部件的焊条弧焊会引起其外表面变形。由于薄板对瞬态局部热膨胀和收缩的弹塑性反应 ,使焊接产生了残余应力和变形。本研究采用通用的ABAQUS有限元程序对焊接过程进行了数学模拟 ,用耦合热力学分析计算了瞬态温度场及相关的应力、应变和应变场。为了改善车厢壳体的外观 ,提出了一种称为磁性成形的技术。其目的在于恢复已变形的侧板的原始几何形状。本文对该技术的有效性作了详细的研究。根据计算 ,用于薄板矫平和矫直的模拟磁性成形技术产生了良好的效果。 | M.Senthil Kumaran 严保平 邹稳根 | 2001 | 国外机车车辆工艺2001，，3： | 2 |
| 12 | Antibiotic resistant Esherichia coli strains from seafood and its susceptibility to seaweed extracts显示文摘Objective:To determine the prevalence and antibiotic resistance of Escherichia coli(E. coli),in seafood obtained from Cuddalore and Parangipettai fish landing centres.Also,to identify the susceptibility of E.coli against predominant seaweeds red alga Kappaphycus alvarezii(K.alvarezii) and brown alga Padina boergessenii(P.boergessenii) extracts as sulfated polysaccharides and polyphenols respectively.Methods:A total of 48 samples(Two stations Cuddalore and Parangipettai,Tamil Nadu,India).Sampling area are fish landing centre where fishes caught from sea and estuary,seafood processing plants(packing and ice packed fishes) and local fish markets(fish samples).After isolation totally 80 strains were analyzed for its antimicrobial resistance and sensitivity against commercially 10 antibiotics.The ampicillin resistant E.coli CE21 was identified through molecular techniques as I6S rDNA sequencing. Two seaweeds K.alvarezii and P.boergessenii were screened lor antibacterial activity against 12 antibiotic resistant E.coli strains.Results:Totally 48 swabbed samples from two different fish handling area were characterized for total bacterial and E.coli count.Mostly,the E.coli strains were isolated from fish local market and seafood processing plants before and after packaging process.In that maximum 56.25%strains were resistant to ampicillin and the minimum 2.5%strains were resistant to chloramphenicol.Therefore,the E.coli CE21 was identified through molecular techniques E.coli(GenBank accession number GU065251),The MIC value for polyphenol extract was slightly less than sulfated polysaccharides.E.coli strain isolated from Parangipettai was considerably increased MIC value that Cuddalore.Conclusions: The polyphenol and sulfated polysaccharides showed promising inhibitory response against all antimicrobial resistant E.coli strains and in particular the inhibitory response of ampicillin resistant E.coli. | Subramanian Kumaran Balaraman Deivasiganiani Kumarappan Alagappan Mannikam Sakthivel Rajamani Karthikeyan | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，12： | 1 |
| 13 | Mixing and combustion characteristics of kerosene in a model supersonic combustor 显示文摘 | Kumaran K Babu V | 2009 | Journal of Pro- pulsion and Power2009，25，3： | 1 |
| 14 | A study on coronal incision for treating zygomatic complex fractures显示文摘 | Shetty SK Saikrishna D Kumaran S | 2009 | J Maxillofac Oral Surg2009，8，2： | 1 |
| 15 | Caffeic acid protects rat heart mitochondria against isoproterenol-induced oxidative damage显示文摘 | KUMARAN K S PRINCE P S | 2010 | Cell Stress and Chaperones2010，15，： | 1 |
| 16 | Effect of DL-α-lipoic acid on the status of lipid peroxidation and antioxidant enzymes in various brain regions of aged rats显示文摘 | Arivazhagan P Shila S Kumaran C | 2002 | Exp Gerontology2002，37，6： | 1 |
| 17 | Application of a cholinesterase biosensor to screen for organophosphorus pesticides extracted from soil 显示文摘 | Satish Kumaran Masatoshi Morita | 1995 | Talanta1995，42，4： | 1 |
| 18 | Providing quality of service over a shared wireless link显示文摘 | ANDREWS M KUMARAN K RAMANAN K | 2001 | IEEE Communications Magazine2001，，： | 1 |
| 19 | Repletion of antioxidant status by EGCG and retardation of oxidative damage induced macromolecular anomalies in aged rats 显示文摘 | SENTHIL KUMARAN V ARULMATHI K SRIVIDHYA R | 2008 | Exp Gerontol2008，43，3： | 1 |
| 20 | Problem solving with the Delphi technique显示文摘 | Kumaran KM Lemieux M Satehell G | 1976 | Dimens Health Serv1976，53，8： | 1 |
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