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| 1 | MicroRNAs as a potential prognostic factor in gastric cancer显示文摘AIM:To compare the microRNA (miR) profiles in the primary tumor of patients with recurrent and non-recurrent gastric cancer.METHODS:The study group included 45 patients who underwent curative gastrectomies from 1995 to 2005 without adjuvant or neoadjuvant therapy and for whom adequate tumor content was available.Total RNA was extracted from formalin-fixed paraffin-embedded tumor samples,preserving the small RNA fraction.Initial profiling using miR microarrays was performed to identify potential biomarkers of recurrence after resection.The expression of the differential miRs was later verified by quantitative real-time polymerase chain reaction (qRT-PCR).Findings were compared between patients who had a recurrence within 36 mo of surgery (bad-prognosis group,n=14,31%) and those who did not (good-prognosis group,n=31,69%).RESULTS:Three miRs,miR-451,miR-199a-3p and miR-195 were found to be differentially expressed in tumors from patients with good prognosis vs patients with bad prognosis (P<0.0002,0.0027 and 0.0046 respectively).High expression of each miR was associated with poorer prognosis for both recurrence and survival.Using miR-451,the positive predictive value for non-recurrence was 100% (13/13).The expression of the differential miRs was verified by qRT-PCR,showing high correlation to the microarray data and similar separation into prognosis groups.CONCLUSION:This study identified three miRs,miR-451,miR-199a-3p and miR-195 to be predictive of recurrence of gastric cancer.Of these,miR-451 had the strongest prognostic impact. | Baruch Brenner Moshe B Hoshen Ofer Purim Miriam Ben David Karin Ashkenazi Gideon Marshak Yulia Kundel Ronen Brenner Sara Morgenstern Marisa Halpern Nitzan Rosenfeld Ayelet Chajut Yaron Niv Michal Kushnir | 2011 | World Journal of Gastroenterology2011，17，35： | 31 |
| 2 | Tumor microRNA-29a expression and the risk of recurrence in stage IIcolon cancer显示文摘 | Alina Weissmann-Brenner Michal Kushnir Gila Lithwick Yanai Ranit Aharonov Hadas Gibori Ofer Purim Yulia Kundel Sara Morgenstern Marissa Halperin Yaron Niv Baruch Brenner | 2012 | International Journal of Oncology2012，，： | 2 |
| 3 | ls local excision after complete pathological response to neoadjuvant chemoradiation for rectal cancer an acceptable treatment option? 显示文摘 | Kundel Y Brenner R Purim O | 2010 | Dis Co Ion Rectum2010，53，12： | 1 |
| 4 | Calcaneal frac- tures : Operative versus nonoperative treatment 显示文摘 | Kundel K Funk E Brutscher M | 1996 | J Trauma1996，41，5： | 1 |
| 5 | Interleakin-8 as a macrophage derived mediator of angiogenesis显示文摘 | Koch AE Polverinin PS Kundel SL | 1992 | Science1992，258，： | 1 |
| 6 | Measurement of observer agreement显示文摘 | Kundel HL Polansky M | 2003 | Radiology2003，228，： | 1 |
| 7 | Is local excision after complete pathological response to neoadjuvant chemoradiation for rectal cancer an acceptable treatment option? 显示文摘 | Kundel Y Brenner R Purim O | 2010 | Dis Colon Rectum2010，53，12： | 1 |
| 8 | Adjuvant chemotherapy and whole abdominal irradiation for gastric carcinoma 显示文摘 | Kundel Y Levitt M L Oberman B | 2008 | Tumor2008，94，4： | 1 |
| 9 | The effects of kilovoltage on diagnostic accuracy in chest radiography显示文摘 | Evesz G Shea FJ and Kundel HL | 1982 | Radiology1982，142，： | 1 |
| 10 | Nuclear magnetic resonance characteristics of fresh and fixed tissue:the effect of elapaed time显示文摘 | Thickman DJ Kundel HL Wolf G | 1983 | Radiology1983，148，2： | 1 |
| 11 | Preoperative ehemoradiation and cetuximab for resectable,locally advanced esophageal cancer: Preliminary results of a prospective phase I b/II trial 显示文摘 | Brenner B Kundel Y Purim O | 2012 | J Clin Oncol2012，，14： | 1 |
| 12 | Pulmonary nodule detection In CT images with quantized convergence index filter显示文摘 | MATSUMOTO S KUNDEL H L | 2006 | Medical Image Analysis2006，10，： | 1 |
| 13 | Assessment of response of brain metastases to radiotherapy by PET imaging of apoptosis with 18F-ML-10显示文摘 | Aaron Allen Miri Ben-Ami Ayelet Reshef Adam Steinmetz Yulia Kundel Edna Inbar Ruth Djaldetti Tal Davidson Eyal Fenig Ilan Ziv | 2012 | European Journal of Nuclear Medicine and Molecular Imaging2012，，9： | 1 |
| 14 | Adjuvant chemothcrapy and whole abdominal irvadiation for gastric carcinoma显示文摘 | Kundel Y Levitt ML Oberman B | | 0，，04： | 1 |
| 15 | Is local excision after complete pathological response to neoadjuvant chemoradiation for rectal cancer an acceptable treatment option? 显示文摘 | Kundel Y Brenner R Purim O | 2010 | Dis Colon Rectum2010，53，12： | 1 |
| 16 | Is local excision after complete pathological response to neoadjuvant chemoradiation for rectal cancer an acceptable treatment option 显示文摘 | Kundel Y Brenner R Purim O | 2010 | Dis Colon Rectum2010，53，12： | 1 |
| 17 | Intraarticular distal humerus fractures :Factors affecting functional outcome显示文摘 | Kundel K Braun W Wieberneit J | 1996 | Clin Orthop Relat Res1996，，332： | 1 |
| 18 | Interpreting chest radiographs without visual seareh显示文摘 | Kundel H L Nodine C F | 1975 | Radiology1975，116，： | 1 |
| 19 | Pulmonary nodule detection in CT images with quantized convergence index fiter显示文摘 | Mastumoto S Kundel HL Gee JC Gefter WB | 2006 | Medical Image analysis2006，10，： | 1 |
| 20 | Measurement of observer agree- ment 显示文摘 | Kundel H L Polansky M | 2003 | Radiology2003，228，： | 1 |
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