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| 1 | Role of Toll-like receptors in health and diseases of gastrointestinal tract显示文摘人胃肠(官方补给) 道被非病原的共栖的微植物群开拓殖民地于并且经常暴露了到许多病原的有机体。为官方补给的动态平衡的维护,主人必须在病原、非病原的有机体之间区别并且开始有效、适当的有免疫力、煽动性的回答。哺乳动物的像使用费的受体(TLR ) 是模式识别受体(PRR ) 的成员在对微生物引起的病原体的天生的细胞的有免疫力的回答和随后的适应有免疫力的回答的开始起一个中央作用的家庭。最近的研究证明了胃肠的上皮细胞表示描绘到日期的几乎所有 TLR 子类型并且在官方补给的道的 TLR 的表示和激活紧并且并列地被调整。这评论在肠的上皮细胞通过 TLR 的表面表示的下面规定在天生的主人和对共栖的细菌的对官方补给的感染和有免疫力的忍耐的维护的适应有免疫力的回答的开发总结 TLR 的关键双角色的当前的理解。 | Greg Harris Rhonda KuoLee | 2006 | World Journal of Gastroenterology2006，12，14： | 6 |
| 2 | Intestinal M cells:The fallible sentinels?显示文摘The gastrointestinal tract represents the largest mucosal membrane surface in the human body. The immune system in the gut is the first line of host defense against mucosal microbial pathogens and it plays a crucial role in maintaining mucosal homeostasis. Membranous or microfold cells, commonly referred to as microfold cells, are specialized epithelial cells of the gut-associated lymphoid tissues (GALT) and they play a sentinel role for the intestinal immune system by delivering luminal antigens through the follicle-associated epithelium to the underlying immune cells. M cells sample and uptake antigens at their apical membrane, encase them in vesicles to transport them to the basolateral membrane of M cells, and from there deliver antigens to the nearby lymphocytes. On the flip side, some intestinal pathogens exploit M cells as their portal of entry to invade the host and cause infections. In this article, we briefly review our current knowledge on the morphology, development, and function of M cells, with an emphasis on their dual role in the pathogenesis of gut infection and in the development of host mucosal immunity. | Harvey Miller Rhonda KuoLee Girishchandra B Patel | 2007 | World Journal of Gastroenterology2007，13，10： | 6 |
| 3 | High susceptibility to respiratory Acinetobacter baumannii infection in A/J mice is associated with a delay in early pulmonary recnuitment of neutrophils显示文摘 | Qiu H KuoLee R Harris G | 2009 | Microbes Infect2009，11，12： | 1 |
| 4 | In vitro and in vivo bi- ological activities of iron chelators and gallium nitrate against Acin- etobacter baumannii 显示文摘 | de L6s61euc L Harris G Kuolee R | 2012 | Antimicrob Agents Chemother2012，56，10： | 1 |
| 5 | Serum resistance, gal- lium nitrate tolerance and extrapulmonary dissemination are linked to heme consumption in a bacteremie strain of Acinetobacter bau- mannii显示文摘 | de Ls61euc L Harris G KuoLee R | 2014 | Int J Med Microbiol2014，304，34： | 1 |
| 6 | 3, 5-Cyclic diguanylic acid elicits mucosal immunity against bacterial infection显示文摘 | Yah H KuoLee R Tram K | 2009 | Biechem Biophys Res Commun2009，387，3： | 1 |
| 7 | Role of macrophages in early host resistance to respiratory Acinetobacter baumannii infection显示文摘 | Qiu H KuoLee R Harris G | 2012 | PloS one2012，7，40： | 1 |
| 8 | Synthesis and immunostimulatory properties of the phosphomthioate analogues of c-di-GMP显示文摘 | Yan H Wang X KuoLee R | 2008 | Bioorg Med Chem Lett2008，18，20： | 1 |
| 9 | Inhibition of airway eosinophilia and pulmonary pathology in a mouse model of allergic asthma by the live vaccine stain of Francisella tularensis显示文摘 | KuoLee R Zhou H Harris G | 2008 | Clin Exp Allergy2008，38，6： | 1 |
| 10 | Acinetobaeter baumannii in- fection inhibits airway eosinophilia and lung pathology in a mouse model of allere asthma 显示文摘 | Qiu H Kuolee R Harris G | 2011 | PLoS One2011，6，22： | 1 |
| 11 | A mouse model of Acinetobacter baumannii-associated pneumonia using aclinically isolated hypervirulent strain显示文摘 | Harris G KuoLee R Lam CK | 2013 | Antimicrob Agents Chemother2013，57，36： | 1 |
| 12 | Synthesis and immunostimulatory properties of the phosphorothioate analogues of cdiGMP 显示文摘 | Yan H Wang X KuoLee R | 2008 | Bioorg Med Chem Lett2008，18，20： | 1 |
| 13 | High susceptibility torespiratory Acinetobacter baumannii infection in A/J miceis associated with a delay in early pulmonary recruitment ofneutrophils显示文摘 | Qiu HY KuoLee R Harris G | 2009 | Microbes Infect2009，11，12： | 1 |
| 14 | Aerosol-, but not intradermal- immunization with the live vaccine strain of Francisella tularensis protects mice against subsequent aerosol challenge with a highly vir- ulent type A strain of the pathogen by an α T cell- and interferon γ- dependent mechanism 显示文摘 | Colan JW Shen H Kuolee R | 2005 | Vaccine2005，23，19： | 1 |
| 15 | Intranasal immunization protects against Acinetobacter baumannii-associated pneumonia in mice显示文摘 | KuoLee R Harris G Yan H | 2015 | Vaccine2015，33，1： | 1 |
| 16 | Synthesis and inmlunostimulatory properties of the phosphorothioate analogues of c-di-GMP 显示文摘 | Yah H Wang X KuoLee R | 2008 | Bioorg Med Chem Lett2008，18，20： | 1 |
| 17 | Salmonella Landau as a Live Vaccine against Escherichia coli O157:H7 Investigated in a Mouse Model of Intestinal Colonization 显示文摘 | Conlan J W KuoLee R Webb A | 1999 | Can J Microbiol1999，45，9： | 1 |
| 18 | Synthesis and iannnnostimulatory properties of the phosphorothioate analogues of cdiGMP 显示文摘 | Yan H Wang X KuoLee R | 2008 | Bioorg Med Chem Lett2008，18，20： | 1 |
| 19 | Design and immunological properties of Helicobacter pylori glycoconjugates based on a truncated lipopolysaccharide lacking Lewis antigen and comprising an α-1,6-glucan chain显示文摘 | Eleonora Altman Vandana Chandan Blair A. Harrison Roberto Veloso-Pita Jianjun Li Rhonda KuoLee Wangxue Chen Vicente Vérez-Bencomo | 2012 | Vaccine2012，，50： | 1 |
| 20 | Pentabodymediated antigen delivery induces antigen-specific mucosal immune response显示文摘 | LI Sheng-hua ZHENG Wen-ju RHONDA KUOLEE | 2009 | Mole Immunol2009，46，9： | 1 |
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