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| 1 | Sitagliptin,sitagliptin and metformin,or sitagliptin and amitriptyline attenuate streptozotocin-nicotinamide induced diabetic neuropathy in rats显示文摘Diabetic neuropathies are a family of nerve disorders caused by diabetes.Symptoms of the disease include nerve palsy,mononeuropathy,mononeuropathy multiplex,diabetic amyotrophy,painful polyneuropathy,autonomic neuropathy,and thoracoabdominal neuropathy.In this study,type 2 diabetes in rats was induced with nicotinamidestreptozotocin.Drug treatment was initiated on the d 15,with the combination regimen of metformin,pioglitazone and glimipiride or metformin and sitagliptin or sitagliptin,amitriptyline and sitagliptin and led to significantly improved glycemic control,increased grip strength and paw jumping response on d 21,28 and 35(P < 0.001).Significant increases in blood protein levels and decreases in urinary protein levels were observed in the animals treated with the different regimens on d 21,28 and 35(P < 0.001).Combined treatment of streptozotocin and nicotinamide caused marked degeneration of nerve cells,while administration of metformin and sitagliptin showed tissue regeneration and no body weight gain.In conclusion,treatment with sitagliptin and sitagliptin combined with metformin or amitriptyline results in no body weight gain,but causes an increase in grip strength and pain sensitivity,exhibits neural protection,and reverses the alteration of biochemical parameters in rats with streptozotocin-nicotinamide induced type 2 diabetes. | Ashish Kumar Sharma Akash Sharma Rita Kumari Kunal Kishore Divya Sharma Bharthu Parthsarthi Srinivasan Ashok Sharma Santosh Kumar Singh Samir Gaur Vijay Singh Jatav Prashant Sharma Varnika Srivastava Sneha Joshi Megha Joshi Prashant Kumar Dhakad Davender Singh Kanawat Akanksha Mishra Anil Sharma Dharmendra Singh Ravinder Pal Singh Himmat Singh Chawda Rambir Singh Sachin Kumar Raikwar Muneem Kumar Kurmi Pankaj Khatri Ashutosh Agarwal Arshee Munajjam | 2012 | The Journal of Biomedical Research2012，26，3： | 2 |
| 2 | In vitro evaluation of a manganese chloride phantom-based MRI technique for quantitative determination of lumbar intervertebral disc com- position and condition显示文摘 | Smith LJ Kurmis AP Slavotinek JP | 2011 | Eur Spine J2011，20，3： | 1 |
| 3 | Diagnosis and Prognostic Significance of Minimal Hepatic Encephalopathy in Patients with Cirrhosis of Liver显示文摘 | Radha K. Dhiman Roshan Kurmi Kiran K. Thumburu Sunil H. Venkataramarao Ritesh Agarwal Ajay Duseja Yogesh Chawla | 2010 | Digestive Diseases and Sciences2010，，8： | 1 |
| 4 | Understanding the limitation of the journal impact factor 显示文摘 | Kurmis AP | 2003 | J Bone Jiont Surg Am2003，85，12： | 1 |
| 5 | Micro-and nanocarrier-mediated lung targeting显示文摘 | Kurmi B D Kayat J Gajbhiye V | 2010 | Expert Opin Drug Deliv2010，7，7： | 1 |
| 6 | Diagnosis and Prognostic Significance of Minimal Hepatic Encephalopathy in Patients with Cirrhosis of Liver显示文摘 | Radha K. Dhiman Roshan Kurmi Kiran K. Thumburu Sunil H. Venkataramarao Ritesh Agarwal Ajay Duseja Yogesh Chawla | 2010 | Digestive Diseases and Sciences2010，，8： | 1 |
| 7 | Understanding the Limitations of the Journal Impact Factor 显示文摘 | Andrew P Kurmis | 2003 | The Journal of Bone & Joint Surgery2003，85，12： | 1 |
| 8 | The effect of nonsteroidal anti - inflammatory drug administration on acute phase fracture - heal- ing: a review显示文摘 | Kurmis AP Kurmis TP O'Brien JX | 2012 | J Bone Joint Surg Am2012，94，9： | 1 |
| 9 | Development and in vitro evaluation of an oral floating matrix tablet formulation of diltiazem hydrochloride显示文摘 | GAMBHIRE M N AMBADE K W KURMI S D | 2007 | AAPS Pharm Sci Tech2007，8，3： | 1 |
| 10 | In vitro eval- uation of a manganese chloride phantom-based MRI technique for quantitative determination of lumbar inter- vertebral disc composition and condition显示文摘 | Simth LJ Kurmis AP Slavotinek JP | 2011 | Eur Spine J2011，20，3： | 1 |
| 11 | COPD and chronic bronchitis risk of indoor air pollution from solid fuel: a sys- tematic review and meta- analysis 显示文摘 | Kurmi O P Semple S Simkhada P | 2010 | Thorax2010，65，3： | 1 |
| 12 | COPD and chronic bronchitis risk of indoor air pollution from solid fuel:a systematic review and meta-analysis显示文摘 | Kurmi P Semple S Simkhada P Smith WCS Ayres JG | | 0，，： | 1 |
| 13 | Understanding the limitations of the journal impact factor显示文摘 | KURMIS A P | 2003 | The Journal of Bone & Joint Surgery2003，85，12： | 1 |
| 14 | Performance eval- uation of RGB skin color segmentation based face detection tech- nique 显示文摘 | Kurmi U S Srivastava H S Agrawal D | 2014 | International Journal of Engineering Universe for Sci- entific Research and Management2014，6，2： | 1 |
| 15 | Brain perfusion single photon emission computed tomography abnormalities in patients with minimal hepatic encephalopathy显示文摘 | Sunil HV Mittal BR Kurmi R | | 0，，02： | 1 |
| 16 | The effect of nonsteroidal anti-inflammatory drug administration on acute phase fracture-healing: a review显示文摘 | Kurmis AP Kurmis TIe O'Brien JX | 2012 | J Bone Joint Surg Am2012，94，9： | 1 |
| 17 | Lung cancer risk and solid fuel smoke exposure: a systematic review and meta-analysis 显示文摘 | KURMI OP ARYA PH LAM KB | 2012 | European Respiratory Journal2012，40，5： | 1 |
| 18 | The use of immunonutrition in burn injury care: where are we? 显示文摘 | Kurmis R Parker A Greenwood J | 2010 | J Burn Care Res2010，3，5： | 1 |
| 19 | COPD and chronic bron ehitis risk of indoor air pollution from solid fuel:A systematic re- view and meta-analysis显示文摘 | Kurmi OP Semple S Simkhada P | 2010 | Thorax2010，65，3： | 1 |
| 20 | COPD and chronic bronchitis risk of indoor air pollution from solid fuel:a systematic review and meta-analysis显示文摘 | Kurmi OP Semple S Simkhada P | | 0，，03： | 1 |
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