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| 1 | A nuclear import inhibitory peptide ameliorates the severity of cholecystokinin-induced acute pancreatitis显示文摘AIM: To assess the effect of our novel cell-permeable nuclear factor-kappaB (NF-κB) inhibitor peptide PN50 in an experimental model of acute pancreatitis. PN50 was produced by conjugating the cell-penetrating penetratin peptide with the nuclear localization signal of the NF-κB p50 subunit.METHODS: Pancreatitis was induced in male Wistar rats by administering 2×100 μg/kg body weight of cholecystokininoctapeptide (CCK) intraperitoneally (IP) at an interval of 1 h. PN50-treated animals received 1 mg/kg of PN50 IP 30 min before or after the CCK injections. The animals were sacrificed 4 h after the first injection of CCK.RESULTS: All the examined laboratory (the pancreatic weight/body weight ratio, serum amylase activity,pancreatic levels of TNF-α and IL-6, degree of lipid peroxidation, reduced glutathione levels, NF-κB binding activity, pancreatic and lung myeloperoxidase activity) and morphological parameters of the disease were improved before and after treatment with the PN50 peptide.According to the histological findings, PN50 protected the animals against acute pancreatitis by favoring the induction of apoptotic, as opposed to necrotic acinar cell death associated with severe acute pancreatitis.CONCLUSION: Our study implies that reversible inhibitors of stress-responsive transcription factors like NF-κB might be clinically useful for the suppression of the severity of acute pancreatitis. | Tamás Letoha Csaba Somlai Tamáas Takács Annamária Szabolcs Katalin Jármay Zoltán Rakonczay Jr Péter Hegyi Ilona Varga József Kaszaki István Krizbai Imre Boros Ern(?) Duda Erzsébet Kusz Botond Penke | 2005 | World Journal of Gastroenterology2005，11，7： | 15 |
| 2 | Ultrasound measurement of rotator cuff thickness and acromio-humera! distance in the diagnosis of subacromial impingement syn- drome of the shoulder显示文摘 | Cholewinski JJ Kusz DJ Wojciechowski P | 2008 | Knee Surg Sports Traumatol Ar- throse2008，16，： | 1 |
| 3 | Complications of arthroscopy of the knee显示文摘 | Pierzchala A kusz D Widuchowski J | 2003 | Wiad Alek2003，56，： | 1 |
| 4 | Evaluation of 316L porous stainless steel for SOFC supports 显示文摘 | MOLIN S GAZDA M KUSZ B | 2008 | Journal of the European Ceramic Society2008，29，4： | 1 |
| 5 | Peripheral nerve compression neuropathy after fractures of the distal radius显示文摘 | Bienek T Kusz D Cielinski L | | 0，，： | 1 |
| 6 | Electronic conduction in (Bi,Pb)-Sr-Ca-Cu-O glass-ceramics显示文摘 | GAZDA M KUSZ B STIZZA S | 2007 | J Non-Cryst Solids2007，353，1112： | 1 |
| 7 | Lisfrane injury - fixation with Kirschner wires显示文摘 | Dudko S Kusz D Pierrzchaa A | 2004 | Foot Ankle Surg2004，1，： | 1 |
| 8 | Complication of arthroscopy of the knee显示文摘 | Pierzchala A Kusz D Widuchowski J | 2003 | Wiad Lek2003，910，： | 1 |
| 9 | Complications of arthroscopy of the knee显示文摘 | Pierzchala A Kusz D Widuchowski J | 2003 | Wiad Lek2003，56，： | 1 |
| 10 | Peripheral nerve compression neuropathy after fractures of the distal radius显示文摘 | Bienek T Kusz D Cielinski L | 2006 | J Hand Surg Br2006，31，3： | 1 |
| 11 | Retransfusion of shed blood collected in drains after total knee replacement 显示文摘 | Cielinski L Kusz D Hajduk G | 2010 | Ortop Traumatol Rehabil2010，12，2： | 1 |
| 12 | Neglected, de- velopmental hip dislocation treated with external, iliofemoral distraction, open reduction, and pelvic osteotomy 显示文摘 | Wojciechowski P Kusz DJ Cielinski S | 2012 | J Ped- iatr orthop B2012，21，3： | 1 |
| 13 | Incomplete masculinisation of XX subjects carrying the SRY gene on an inactive X chromosome显示文摘 | Kusz K Kotecki M Wojda A | 1999 | F Med Genet1999，36，： | 1 |
| 14 | Propylene-Glycol aggravates LPS-induced sepsis through production of TNF-et and IL-6显示文摘 | Marion A Kolozsi C Kusz E el al | 2014 | I- ran J Immunol2014，11，2： | 1 |
| 15 | Comp - cation of arthroscopyofthe knee 显示文摘 | PIERZCHALA A KUSZ D WIDUCHOWSKI J | 2002 | Acta Anesthesiol Stand2002，46，4： | 1 |
| 16 | Complications of arthroscopy of the knee显示文摘 | Pierzchala A Kusz D Widuchowski J | 2002 | Acta Anesthesiol Stand2002，46，4： | 1 |
| 17 | Minimally invasive approaches in total hip arthroplasty 显示文摘 | Wojciechowski P1 Kusz D Kope K | 2007 | Ortop Traumatol Rehabi12007，9，1： | 1 |
| 18 | The effects of treat- ment the avascular necrosis of the femoral headwithex- tracorporealfocusedshockwavetherapy 显示文摘 | Kusz d Franek A Wilk R | 2012 | Orthop Trau- matol Rehabil2012，14，5： | 1 |
| 19 | In vitro and in vivo nuclear factor-kappaB inhibitory effects of the cell-penetrating penetratin peptide显示文摘 | Letoha T Kusz E Papai G | 2006 | Mol Pharmacol2006，69，6： | 1 |
| 20 | Peripheral nerve compression neuropathy after frac-tures of the distal radius显示文摘 | Bienek T Kusz D Cielinski L | 2006 | J Hand Surg Br2006，31，3： | 1 |
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