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| 1 | Specific endoscopic features of ulcerative colitis complicated by cytomegalovirus infection显示文摘AIM:To identify specific colonoscopic findings in patients with ulcerative colitis (UC) complicated by cyto-megalovirus (CMV) infection.METHODS: Among UC patients who were hospitalized due to exacerbation of symptoms, colonoscopic findings were compared between 15 CMV-positive patients and 58 CMV-negative patients. CMV infection was determined by blood test for CMV antigenemia. Five aspects of mucosal changes were analyzed (loss of vascular pattern, erythema, mucosal edema, easy bleeding, and mucinous exudates) as well as five aspects of ulcerative change (wide mucosal defect, punched-out ulceration, longitudinal ulceration, irregular ulceration, and cobble-stone-like appearance). Sensitivity, specificity, positive predictive value, and negative predictive value of each finding for CMV positivity were determined.RESULTS: The sensitivity of irregular ulceration for positive CMV was 100%. The specificity of wide mucosal defect was 95%. Punched-out ulceration and lon-gitudinal ulceration exhibited relatively high sensitivity and specificity (more than 70% for each).CONCLUSION:Specific colonoscopic findings in patients with UC complicated by CMV infection were identified. These findings may facilitate the early diagnosis of CMV infection in UC patients. | Hideyuki Suzuki Jun Kato Motoaki Kuriyama Sakiko Hiraoka Kenji Kuwaki Kazuhide Yamamoto | 2010 | World Journal of Gastroenterology2010，16，10： | 19 |
| 2 | Antibody markers in the diagnosis of inflammatory boweldisease显示文摘Inflammatory bowel disease(IBD), including Crohn's disease and ulcerative colitis, is a chronic intestinal inflammation of unknown etiology. The diagnosis of IBD is based on endoscopic, radiologic and histopathologic criteria. Recently, the search for a noninvasive marker that could augment or replace part of this diagnostic process has become a focus of IBD research. In this review, antibody markers, including microbial antibodies, autoantibodies and peptide antibodies, will be described, focusing on their common features. At present, no single marker with qualities that are satisfactory for the diagnosis and treatment of IBD has been identified, although panels of some antibodies are being evaluated with keen interest. The discovery of novel IBD-specific and sensitive markers is anticipated. Such markers could minimize the use of endoscopic and radiologic examinations and could enable clinicians to implement individualized treatment plans designed to improve the long-term prognosis of patients with IBD. | Keiichi Mitsuyama Mikio Niwa Hidetoshi Takedatsu Hiroshi Yamasaki Kotaro Kuwaki Shinichiro Yoshioka Ryosuke Yamauchi Shuhei Fukunaga Takuji Torimura | 2016 | World Journal of Gastroenterology2016，22，3： | 12 |
| 3 | study to determine guidelines for pediatric colonoscopy显示文摘AIM To investigated characteristics, diagnosis, bowelcleansing preparation, sedation, and colonoscope length and diameter in Japanese pediatric patients receiving total colonoscopy.METHODS The present study evaluated consecutive patients aged ≤ 15 years who had undergone their first colonoscopy in Kurume University between January 2007 and February 2015. Data were retrospectively analyzed. We identified 110 pediatric patients who had undergone colonoscopy that had reached the cecum, allowing the observation of the total colon.RESULTS Hematochezia, abdominal pain, and diarrhea were the most common symptoms. For bowel-cleansing preparation, pediatric patients aged ≤ 12 years were treated with magnesium citrate, and patients aged 13-15 years were treated with polyethylene glycol 4000. For sedation, thiamylal with pentazocine, which has an analgesic effect, was used in patients aged ≤ 6 years, and midazolam with pentazocine was used in patients aged ≥ 7 years. Regarding the choice of endoscope, short and thin endoscopes were selected for younger patients, particularly patients aged ≤ 3 years. Positive diagnoses were made in 78 patients(70.9%). Inflammatory bowel disease(n = 49, 44.5%), including ulcerative colitis(n = 37, 33.6%) and Crohn's disease(n = 12, 10.9%), was the most common diagnosis. CONCLUSION Colonoscopy offers a high diagnostic capability for pediatric patients with gastrointestinal symptoms. The selection of appropriate management the performance of colonoscopy is important in pediatric patients. | Shinichiro Yoshioka Hidetoshi Takedatsu Shuhei Fukunaga Kotaro Kuwaki Hiroshi Yamasaki RyosukeYamauchi Atsushi Mori Hiroshi Kawano Tadahiro Yanagi Tatsuki Mizuochi Kosuke Ushijima Keiichi Mitsuyama Osamu Tsuruta Takuji Torimura | 2017 | World Journal of Gastroenterology2017，23，31： | 10 |
| 4 | Risk factors for recurrence after transarterial chemoembolization for early-stage hepatocellular carcinoma显示文摘 | Hideaki Kinugasa Kazuhiro Nouso Yasuto Takeuchi Tetsuya Yasunaka Hideki Onishi Shin-ichiro Nakamura Hidenori Shiraha Kenji Kuwaki Hiroaki Hagihara Fusao Ikeda Yasuhiro Miyake Akinobu Takaki Kazuhide Yamamoto | 2012 | Journal of Gastroenterology2012，，4： | 2 |
| 5 | Ten year's experience of aortic v alve replacement with the Ominicarbon valve prosthesis显示文摘 | Abe T Kamata K Kuwaki K | | Ann Thorac Surg0，61，4： | 1 |
| 6 | Identification and analy-sis of human erythropoietin receptors on a factor-dependentcell line, tf-l显示文摘 | Kitamura T Tojo A Kuwaki T | 1989 | Blood1989，73，： | 1 |
| 7 | Serum Folate and Homocysteine Levels Are Associated With Colon Tumorigenesis in End-Stage Renal Disease Patients显示文摘 | Eisuke Kaji Jun Kato Shunsuke Saito Keita Harada Kenji Kuwaki Masashi Tatsukawa Tamiya Morikawa Sakiko Hiraoka Hiroshi Matsushima Kazuhide Yamamoto | 2011 | Nutrition and Cancer2011，，2： | 1 |
| 8 | Marked improvement of thrombocytopenia in a murine model of idiopathic thrombocytopenic purpura by pegylated recombinant human megakaryocyte growth and development factor显示文摘 | Shibuya K Kuwaki T Tahara E | 2002 | Exp Hematol2002，30，10： | 1 |
| 9 | Thrombotic microangiopathy and graft arteriopathy in pig hearts following transplantation into baboons显示文摘 | Houser SL Kuwaki K Knosalla C | 2004 | Xenotransplantation2004，11，5： | 1 |
| 10 | Antifungal activity of the fermentation product of herbs by lactic acid bacteria against Tinea显示文摘 | Kuwaki S Ohhira I Takahata M | 2002 | Journal of bioscience and bioengineering2002，94，5： | 1 |
| 11 | Heart transplantation in baboons using α1,3-galactosyltransferase gene-knockout pigs as donors:initial experience显示文摘 | Kuwaki K Tseng Y L Dor F | 2005 | Nature Med2005，11，1： | 1 |
| 12 | Development of an analysis system for 24-hour blood pressure and heart rate variability in the rat显示文摘 | Yuhei Ichimaru Tomoyuki Kuwaki | 1998 | Psychiatry Clin Neurosci1998，52，2： | 1 |
| 13 | Rejection of cardi- ac xenografts transplanted from alpha/, 3 - galactosyltransferase gene - knockout ( GaIT - KO) pigs to baboons 显示文摘 | HISASHI Y YAMADA K KUWAKI K | 2008 | Am J Trans- plant2008，8，12： | 1 |
| 14 | Tricuspid valve surgery for functional tricuspid valve regurgitation associated with left-sided valvalar disease显示文摘 | KUWAKI K MORISHITA K TSUKAMOTO M | 2001 | Eur J Cardiothorac Surg2001，20，3： | 1 |
| 15 | Prognostic factors and treatment effects for hepatocellular carcinoma in Child C cirrhosis显示文摘 | Nouso K Ito Y Kuwaki K | | 0，，： | 1 |
| 16 | Prognotic impact of serum follistatin in patients with hepatocellular carcinoma显示文摘 | Takeshi Tomoda Kazuhiro Nouso Koji Miyahara Sayo Kobayashi Hideaki Kinugasa Junki Toyosawa Hiroaki Hagihara Kenji Kuwaki Hideki Onishi Shinichiro Nakamura Fusao Ikeda Yasuhiro Miyake Hidenori Shiraha Akinobu Takaki Kazuhide Yamamoto | 2013 | J Gastroenterol Hepatol2013，，8： | 1 |
| 17 | Heart transplantation in baboons using α-1,3-galactosyl transferase gene-knockoutpigs as donors:initial experience显示文摘 | Kuwaki K Tseng YL Dor FJ etal | 2005 | Nat Med2005，11，： | 1 |
| 18 | Rejection of cardiac xenografts transplanted from α-1,3-galactosyltransferase geneknockout pigs to baboons显示文摘 | Hisashi Y Yamada K Kuwaki K | 2008 | Am J Transplant2008，8，12： | 1 |
| 19 | Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience显示文摘 | Kuwaki K Tseng YL Dor FJ | 2005 | Nat Med2005，11，1： | 1 |
| 20 | Tricuspid valve surgery for functional tricuspid valve regurgitation associated with left-sided valvular disease 显示文摘 | KUWAKI K MORISHITA K TSUKAMOTO M | 2001 | Eur J Cardiothorac Surg2001，20，3： | 1 |
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