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| 1 | Retrospective cohort study Lower incidence of complications in endoscopic nasobiliary drainage for hilar cholangiocarcinoma显示文摘AIM:To identify the most effective endoscopic biliary drainage technique for patients with hilar cholangiocarcinoma.METHODS:In total,118 patients with hilar cholangiocarcinoma underwent endoscopic management[endoscopic nasobiliary drainage(ENBD)or endoscopic biliary stenting]as a temporary drainage in our institution between 2009 and 2014.We retrospectively evaluated all complications from initial endoscopic drainage to surgery or palliative treatment.The risk factors for biliary reintervention,post-endoscopic retrograde cholangiopancreatography(post-ERCP)pancreatitis,and percutaneous transhepatic biliary drainage(PTBD)were also analyzed using patient-and procedure-related characteristics.The risk factors for bilateral drainage were examined in a subgroup analysis of patients who underwent initial unilateral drainage.RESULTS:In total,137 complications were observed in92(78%)patients.Biliary reintervention was required in 83(70%)patients.ENBD was significantly associated with a low risk of biliary reintervention[odds ratio(OR)=0.26,95%CI:0.08-0.76,P=0.012].Post-ERCP pancreatitis was observed in 19(16%)patients.An absence of endoscopic sphincterotomy was significantly associated with post-ERCP pancreatitis(OR=3.46,95%CI:1.19-10.87,P=0.023).PTBD was required in 16(14%)patients,and Bismuth type III or IV cholangiocarcinoma was a significant risk factor(OR=7.88,95%CI:1.33-155.0,P=0.010).Of 102 patients with initial unilateral drainage,49(48%)required bilateral drainage.Endoscopic sphincterotomy(OR=3.24,95%CI:1.27-8.78,P=0.004)and Bismuth II,III,or IV cholangiocarcinoma(OR=34.69,95%CI:4.88-736.7,P<0.001)were significant risk factors for bilateral drainage.CONCLUSION:The endoscopic management of hilar cholangiocarcinoma is challenging.ENBD should be selected as a temporary drainage method because of its low risk of complications. | Kazumichi Kawakubo Hiroshi Kawakami Masaki Kuwatani Shin Haba Taiki Kudo Yoko A Taya Shuhei Kawahata Yoshimasa Kubota Kimitoshi Kubo Kazunori Eto Nobuyuki Ehira Hiroaki Yamato Manabu Onodera Naoya Sakamoto | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，9： | 26 |
| 2 | Three cases of retroperitoneal schwannoma diagnosed by EUS-FNA显示文摘Schwannomas are peripheral nerve tumors that are typically solitary and benign.Their diagnosis is largely based on surgically resected specimens.Recently,a number of case reports have indicated that retroperitoneal schwannomas could be diagnosed with endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA).We report the diagnosis of three cases of schwannoma using EUS-FNA.Subjects were two males and one female,ages 22,40,and 46 years,respectively,all of whom were symptom-free.Imaging findings showed well-circumscribed round tumors.However,as the tumors could not be diagnosed using these findings alone,EUS-FNA was performed.Hematoxylin-eosin staining of the resulting tissue fragments revealed bland spindle cells with nuclear palisading.There was no disparity in nuclear sizes.Immunostaining revealed S-100 protein positivity and all cases were diagnosed as schwannomas.Ki-67 indexes were 3%-15%,2%-3%,and 3%,respectively.No case showed any signs of malignancy.As most schwannomas are benign tumors and seldom become malignant,we observed these patients without therapy.All tumors demonstrated no enlargement and no change in characteristics.Schwannomas are almost always benign and can be observed following diagnosis by EUS-FNA. | Taiki Kudo Hiroshi Kawakami Masaki Kuwatani Nobuyuki Ehira Hiroaki Yamato Kazunori Eto Kanako Kubota Masahiro Asaka | 2011 | World Journal of Gastroenterology2011，17，29： | 8 |
| 3 | Influence of the safety and diagnostic accuracy of preoperative endoscopic ultrasound-guided fine-needle aspiration for resectable pancreatic cancer on clinical performance显示文摘AIM:To evaluate the safety and diagnostic accuracy of endoscopic ultrasound-guided fine-needle aspiration(EUS-FNA)in a cohort of pancreatic cancer patients.METHODS:Of 213 patients with pancreatic cancer evaluated between April 2007 and August 2011,82were thought to have resectable pancreatic cancer on the basis of cross-sectional imaging findings.Of these,54 underwent EUS-FNA before surgery(FNA+group)and 28 underwent surgery without preoperative EUSFNA(FNA-group).RESULTS:All 54 lesions were visible on EUS,and all54 attempts at FNA were technically successful.The diagnostic accuracy according to cytology and histology findings was 98.1%(53/54)and 77.8%(42/54),respectively,and the total accuracy was 98.1%(53/54).One patient developed mild pancreatitis after EUS-FNA but was successfully treated by conservative therapy.No severe complications occurred after EUS-FNA.In the FNA+and FNA-groups,the median relapse-free survival(RFS)was 742 and 265 d,respectively(P=0.0099),and the median overall survival(OS)was1042 and 557 d,respectively(P=0.0071).RFS and OS were therefore not inferior in the FNA+group.These data indicate that the use of EUS-FNA did not influence RFS or OS,nor did it increase the risk of peritoneal recurrence.CONCLUSION:In patients with resectable pancreatic cancer,preoperative EUS-FNA is a safe and accurate diagnostic method. | Taiki Kudo Hiroshi Kawakami Masaki Kuwatani Kazunori Eto Shuhei Kawahata Yoko Abe Manabu Onodera Nobuyuki Ehira Hiroaki Yamato Shin Haba Kazumichi Kawakubo Naoya Sakamoto | 2014 | World Journal of Gastroenterology2014，20，13： | 2 |
| 4 | IgG4-related sclerosing cholangitis and autoimmune pancreatitis : histological assessment of biopsies from Vater' s ampulla and the bile duct 显示文摘 | Kawakami H Zen Y Kuwatani M | 2010 | J Gastroenterol Hepato12010，25，： | 1 |
| 5 | Endoscopic nasobiliary drainage is the most suitable preoperative biliary drainage method in the management of patients with hilar cholangiocarcinoma显示文摘 | Kawakami H Kuwatani M Onodera M | 2011 | J Gastroenterol2011，46，2： | 1 |
| 6 | Endoscopic salvage technique for spontaneous dislocation and tumor ingrowth of a partially covered, self-expandable metallic stent after endoscopic ultrasound-guided choledochoduodenostomy显示文摘 | Hiroshi Kawakami Masaki Kuwatani Kazumichi Kawakubo Taiki Kudo Yoko Abe Kimitoshi Kubo Naoya Sakamoto | 2014 | Endoscopy2014，，： | 1 |
| 7 | Modulation of acute graft-versus-host diseaseand chimerism after adoptive trans- fer of in vitro - expanded invariant Valpha14 natural killer T cells显示文摘 | Kuwatani M Ikarashi Y IizukaA | 2006 | Immunol Lett2006，106，1： | 1 |
| 8 | Candy-like sign during endoscopic ultrasound-guided choledochoduodenostomy as an indication of the long distance between the bile duct and duodenal wall显示文摘 | Hiroshi Kawakami Masaki Kuwatani Kazumichi Kawakubo Taiki Kudo Yoko Abe Kimitoshi Kubo Yoshimasa Kubota Naoya Sakamoto | 2014 | Endoscopy2014，，： | 1 |
| 9 | Recent advances in endoscopic ultrasonography-guided biliary interventions显示文摘Interventional endoscopic ultrasonography(EUS) based on EUS-guided fine-needle aspiration has rapidly spread as a minimally invasive procedure. Especially in patients with failed endoscopic retrograde cholangiopancreatography, EUS-guided biliary intervention is reported to be useful as salvage therapy. EUS-guided biliary interventions are carried out using three techniques: EUS-guided bilioenteric anastomosis, EUS-guided rendezvous procedure, and EUS-guided antegrade treatment. Although interventional EUS is not yet a standardized procedure, there have been recent advances in this field that address various biliary diseases. Here, we summarize the indications, techniques, clinical results of previous studies, and future perspectives. | Kazumichi Kawakubo Hiroshi Kawakami Masaki Kuwatani Shin Haba Shuhei Kawahata Yoko Abe Yoshimasa Kubota Kimitoshi Kubo Hiroyuki Isayama Naoya Sakamoto | 2015 | World Journal of Gastroenterology2015，21，32： | 1 |
| 10 | Modulation of acute graft-versus-host disease and chimerism after adoptive transfer of in vitro-expanded invariant Valphal4 natural killer T cells显示文摘 | Kuwatani M Ikarashi Y Iizuka A | 2006 | Immunol Lett2006，106，1： | 1 |
| 11 | Primary cho lesterol hepatolithiasis associated with cholangiocellular carci noma~ a case report and literature review显示文摘 | Kawakami H Kuwatani M Onodera M | 2007 | Intern Med2007，46，15： | 1 |
| 12 | Primary acinar cell carcinoma of the ampulla of Vater显示文摘 | Hiroshi Kawakami Masaki Kuwatani Manabu Onodera Satoshi Hirano Satoshi Kondo Yoshitsugu Nakanishi Tomoo Itoh Masahiro Asaka | 2007 | Journal of Gastroenterology2007，，8： | 1 |
| 13 | Osteonecrosis and panniculitis as life-threatening signs显示文摘 | Kuwatani M Kawakami H Yamada Y | 2010 | Clin Gastroenterol Hepatol2010，8，5： | 1 |
| 14 | Sol-gel synthe- sis of fluorine-doped silica glasses with low SiOH concentra- tions 显示文摘 | Maehana R Kuwatani S Kajihara K | 2011 | J Ceram Soc Jpn2011，119，1390： | 1 |
| 15 | Modalities for evaluating chemotherapeutic efficacy and survival time in patients with advanced pancreatic cancer: comparison between FDG-PET, CT, and serum tumor markers 显示文摘 | Kuwatani M Kawakami H Eto K | 2009 | Intern Med2009，48，11： | 1 |
| 16 | The role of peroral video cholangioscopy in patients with IgG4-related sclerosing cholangitis显示文摘 | Takao Itoi Terumi Kamisawa Yoshinori Igarashi Hiroshi Kawakami Ichiro Yasuda Fumihide Itokawa Yuui Kishimoto Masaki Kuwatani Shinpei Doi Seiichi Hara Fuminori Moriyasu Todd H. Baron | 2013 | Journal of Gastroenterology2013，，4： | 1 |
| 17 | Modulation of acute graft-versus-host disease and chimerism after adoptive transfer of in vitro-expanded invariant Valphal4 natural killer T cells 显示文摘 | Kuwatani M Ikarashi Y Iizuka A | 2006 | Immunol Lett2006，106，1： | 1 |
| 18 | Multicenter retrospective study of endoscopic ultrasound‐guided biliary drainage for malignant biliary obstruction in J apan显示文摘 | Kazumichi Kawakubo Hiroyuki Isayama Hironari Kato Takao Itoi Hiroshi Kawakami Keiji Hanada Hirotoshi Ishiwatari Ichiro Yasuda Hirofumi Kawamoto Fumihide Itokawa Masaki Kuwatani Tomohiro Iiboshi Tsuyoshi Hayashi Shinpei Doi Yousuke Nakai | 2014 | J Hepatobiliary Pancreat Sci2014，，5： | 1 |
| 19 | Modulation of acute graft- versus-host disease and chimerism after adoptive transfer of in vitro- expanded invariant Valphal4 natural killer T cells 显示文摘 | Kuwatani M Ikarashi Y Iizuka A | 2006 | Immunol Lett2006，106，1： | 1 |
| 20 | Modulation of acute graftversus-host disease and chimerism after adoptive transfer of in vitroexpanded invariant Vα14 natural killer T cells显示文摘 | Kuwatani M Ikarashi Y Iizuka A | 2006 | Immunol Lett2006，106，1： | 1 |
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